HitPredict

Interactor 1: ZN517 (Q6ZMY9)
Zinc finger protein 517
Gene: ZNF517

Interactor 2: SORL (Q92673)
Sortilin-related receptor (Low-density lipoprotein receptor relative with 11 ligand-binding repeats) (LDLR relative with 11 ligand-binding repeats) (LR11) (SorLA-1) (Sorting protein-related receptor containing LDLR class A repeats) (SorLA)
Gene: SORL1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.50	0.574

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 492 Hs			1 2214
+	Hs
		1315906 ZNF34_HUMAN (1-479): 0: 593: 35.99		SORL_HUMAN (1-2214): 0: 1914: 100.00
+	Hs
		1294605 Z354C_HUMAN (70-346): 1.2e-75: 249: 31.32		SORL_HUMAN (1-2214): 0: 1914: 100.00
+	Hs
		1335615 ZN485_HUMAN (178-427): 2.36e-76: 248: 47.81		SORL_HUMAN (1-2214): 0: 1914: 100.00
+	Hs
		1366673 ZN331_HUMAN (171-390): 7.32e-50: 178: 43.89		SORL_HUMAN (1-2214): 0: 1914: 100.00
+	Hs
		1159268 ZNF74_HUMAN (46-204): 1.44e-30: 127: 13.13		SORL_HUMAN (1-2214): 0: 1914: 100.00
+	Hs
		212813 ZN264_HUMAN (54-163): 1.87e-10: 65.1: 6.36		SORL_HUMAN (1-2214): 0: 1914: 100.00
+	Hs
		270567 ZNF34_HUMAN (1-479): 0: 593: 35.99		LRP4_HUMAN (1417-1745): 2.33e-10: 68.5: 13.58
+	Hs
		1022625 ZN517_HUMAN (1-492): 0: 579: 100.00		LRP2_HUMAN (1346-1689): 1.19e-10: 69.6: 16.00
+	Hs
		1252060 ZN517_HUMAN (1-492): 0: 579: 100.00		LRP1B_HUMAN (1345-1603): 1.72e-09: 65.8: 9.93
+	Hs
		287591 ZN383_HUMAN (208-492): 1.35e-146: 429: 46.39		LRP6_HUMAN (1445-1549): 6.83e-11: 70.1: 36.94
+	Hs
		274901 ZN383_HUMAN (208-492): 1.35e-146: 429: 46.39		LRP5_HUMAN (1445-1549): 8.72e-11: 69.7: 37.27
+	Hs
		270572 ZN383_HUMAN (208-492): 1.35e-146: 429: 46.39		LRP4_HUMAN (1417-1745): 2.33e-10: 68.5: 13.58
+	Hs
		270564 Z354C_HUMAN (70-346): 1.2e-75: 249: 31.32		LRP4_HUMAN (1417-1745): 2.33e-10: 68.5: 13.58
+	Hs
		270589 ZN331_HUMAN (171-390): 7.32e-50: 178: 43.89		LRP4_HUMAN (1417-1745): 2.33e-10: 68.5: 13.58
+	Hs
		1447579 ZN331_HUMAN (171-390): 7.32e-50: 178: 43.89		LRP1B_HUMAN (1345-1603): 1.72e-09: 65.8: 9.93
+	Hs
		270555 ZNF74_HUMAN (46-204): 1.44e-30: 127: 13.13		LRP4_HUMAN (1417-1745): 2.33e-10: 68.5: 13.58
+	Hs
		212804 ZN264_HUMAN (54-163): 1.87e-10: 65.1: 6.36		LRP2_HUMAN (1346-1689): 1.19e-10: 69.6: 16.00