HitPredict

Interactor 1: WWP2 (O00308)
NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 2.3.2.26) (Atrophin-1-interacting protein 2) (AIP2) (HECT-type E3 ubiquitin transferase WWP2) (WW domain-containing protein 2)
Gene: WWP2

Interactor 2: IDD (P98153)
Integral membrane protein DGCR2/IDD
Gene: DGCR2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.71	0.60	0.656

Property	Details
Experiments	26186194, 31048545, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0016020 - membrane
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 870 Hs			1 550
+	Hs
		957474 WWP1_HUMAN (1-870): 0: 888: 58.38		IDD_HUMAN (1-550): 4.55e-155: 456: 100.00
+	Hs
		957463 NED4L_HUMAN (5-867): 0: 785: 32.17		IDD_HUMAN (1-550): 4.55e-155: 456: 100.00
+	Hs
		808089 NEDD4_HUMAN (90-867): 0: 731: 35.94		IDD_HUMAN (1-550): 4.55e-155: 456: 100.00
+	Hs
		270320 ITCH_HUMAN (1-870): 0: 902: 54.26		LRP6_HUMAN (178-357): 9.85e-13: 73.4: 9.47
+	Hs
		1205571 ITCH_HUMAN (1-870): 0: 902: 54.26		LRAD3_HUMAN (29-115): 5.91e-10: 63.1: 30.00
+	Mm
		57546 ITCH_MOUSE (1-870): 0: 892: 55.81		LRAD3_MOUSE (29-115): 5.21e-10: 63.1: 30.00
+	Hs
		1205572 WWP1_HUMAN (1-870): 0: 888: 58.38		LRAD3_HUMAN (29-115): 5.91e-10: 63.1: 30.00
+	Hs
		808178 NEDD4_HUMAN (90-867): 0: 731: 35.94		LRAD3_HUMAN (29-115): 5.91e-10: 63.1: 30.00
+	Hs
		957483 SMUF2_HUMAN (1-363): 5.89e-43: 169: 17.62		IDD_HUMAN (1-550): 4.55e-155: 456: 100.00
+	Hs
		957497 HECW2_HUMAN (154-531): 5.96e-16: 84.8: 17.23		IDD_HUMAN (1-550): 4.55e-155: 456: 100.00