HitPredict

Interactor 1: NEK7 (Q8TDX7)
Serine/threonine-protein kinase Nek7 (EC 2.7.11.34) (Never in mitosis A-related kinase 7) (NimA-related protein kinase 7)
Gene: NEK7

Interactor 2: EMAL4 (Q9HC35)
Echinoderm microtubule-associated protein-like 4 (EMAP-4) (Restrictedly overexpressed proliferation-associated protein) (Ropp 120)
Gene: EML4

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.63	0.60	0.619

Property	Details
Experiments	27173435, 31409757
Identification Methods	affinity chromatography technology, enzymatic study, tandem affinity purification
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005815 - microtubule organizing center GO:0005874 - microtubule
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 302 Hs			1 981
+	Hs
		1335710 NEK6_HUMAN (12-302): 1.58e-139: 397: 81.44		EMAL4_HUMAN (1-981): 0: 652: 100.00
+	Hs
		1254380 NEK9_HUMAN (40-290): 1.05e-48: 175: 39.29		EMAL4_HUMAN (1-981): 0: 652: 100.00
+	Hs
		160265 AURKA_HUMAN (2-301): 1.63e-118: 348: 26.30		WDR62_HUMAN (233-942): 1.85e-81: 291: 16.45
+	Hs
		325574 NEK6_HUMAN (12-302): 1.58e-139: 397: 81.44		EMAL2_HUMAN (393-952): 5.15e-48: 184: 10.16
+	Hs
		254137 AKT3_HUMAN (2-294): 6.75e-126: 369: 23.43		WDR1_HUMAN (642-945): 7.61e-35: 143: 11.66
+	Hs
		1104147 NEK6_HUMAN (12-302): 1.58e-139: 397: 81.44		EMAL3_HUMAN (740-959): 1.26e-11: 70.9: 10.42
+	Hs
		1104135 NEK7_HUMAN (1-302): 1.91e-124: 359: 100.00		EMAL3_HUMAN (740-959): 1.26e-11: 70.9: 10.42
+	Hs
		127925 NEK9_HUMAN (40-290): 1.05e-48: 175: 39.29		EMAL1_HUMAN (531-953): 1.99e-32: 137: 7.81
+	Hs
		1104140 NEK1_HUMAN (38-295): 4.6e-53: 188: 38.31		EMAL3_HUMAN (740-959): 1.26e-11: 70.9: 10.42
+	Hs
		1104134 NEK9_HUMAN (40-290): 1.05e-48: 175: 39.29		EMAL3_HUMAN (740-959): 1.26e-11: 70.9: 10.42