HitPredict

Interactor 1: WASL (O00401)
Actin nucleation-promoting factor WASL (Neural Wiskott-Aldrich syndrome protein) (N-WASP)
Gene: WASL

Interactor 2: PROF1 (P07737)
Profilin-1 (Epididymis tissue protein Li 184a) (Profilin I)
Gene: PFN1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.76	0.60	0.676

Property	Details
Experiments	9822597, 10867004, 35271311
Identification Methods	pull down, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003779 - actin binding GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0070062 - extracellular exosome and 1 others more... GO:0098978 - glutamatergic synapse
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 505 Hs			1 140
+	Hs
		203199 SYNJ1_HUMAN (4-500): 4.14e-62: 222: 14.85		PROF1_HUMAN (1-140): 1.1e-77: 227: 100.00
+	Hs
		166025 SYNJ2_HUMAN (3-471): 6.56e-60: 215: 14.85		PROF1_HUMAN (1-140): 1.1e-77: 227: 100.00
+	Hs
		430285 TITIN_HUMAN (345-474): 5.12e-09: 61.3: 17.56		PROF1_HUMAN (1-140): 1.1e-77: 227: 100.00
+	Mm
		923936 PCLO_MOUSE (123-503): 3.9e-09: 61.6: 9.55		PROF1_MOUSE (1-140): 5.37e-77: 226: 95.71
+	Mm
		1337493 PCLO_MOUSE (123-503): 3.9e-09: 61.6: 9.55		PROF2_MOUSE (1-140): 9.83e-75: 220: 61.43