HitPredict

Interactor 1: ESR2 (Q92731)
Estrogen receptor beta (ER-beta) (Nuclear receptor subfamily 3 group A member 2)
Gene: ESR2

Interactor 2: MKNK2 (Q9HBH9)
MAP kinase-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 2) (MAPK signal-integrating kinase 2) (Mnk2)
Gene: MKNK2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.481

Property	Details
Experiments	11013076
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 530 Hs			1 465
+	Hs
		1039133 ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00		KCC2D_HUMAN (71-413): 8.01e-120: 361: 31.23
+	Hs
		377307 GCR_HUMAN (3-495): 1.12e-103: 330: 22.64		KCC2D_HUMAN (71-413): 8.01e-120: 361: 31.23
+	Hs
		369218 ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56		KS6A3_HUMAN (89-360): 1.03e-23: 106: 30.69
+	Hs
		369662 ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56		KS6A1_HUMAN (89-360): 9.83e-22: 100: 29.71
+	Hs
		587205 RXRA_HUMAN (13-502): 1.6e-119: 361: 25.71		KS6A6_HUMAN (89-362): 1.17e-24: 109: 30.47
+	Hs
		270361 GCR_HUMAN (3-495): 1.12e-103: 330: 22.64		KS6A5_HUMAN (89-375): 8.72e-25: 109: 29.33
+	Hs
		611521 NR4A1_HUMAN (7-501): 3.18e-101: 318: 25.30		KS6A6_HUMAN (89-362): 1.17e-24: 109: 30.47
+	Hs
		487459 ANDR_HUMAN (149-407): 8.1e-38: 150: 32.59		KS6A1_HUMAN (89-360): 9.83e-22: 100: 29.71