HitPredict

Interactor 1: HDAC2 (Q92769)
Histone deacetylase 2 (HD2) (EC 3.5.1.98) (Protein deacylase HDAC2) (EC 3.5.1.-)
Gene: HDAC2

Interactor 2: H2AW (Q9P0M6)
Core histone macro-H2A.2 (Histone macroH2A2) (mH2A2)
Gene: MACROH2A2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.500

Property	Details
Experiments	19734898
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0000781 - chromosome, telomeric region GO:0000785 - chromatin GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 488 Hs			1 372
+	Hs
		260953 HDAC2_HUMAN (1-488): 0: 707: 100.00		H2AY_HUMAN (1-371): 8.19e-156: 444: 66.31
+	Hs
		260877 HDAC1_HUMAN (1-443): 0: 642: 90.07		H2AY_HUMAN (1-371): 8.19e-156: 444: 66.31
+	Hs
		555567 HDAC2_HUMAN (1-488): 0: 707: 100.00		H2AX_HUMAN (1-144): 1.72e-66: 208: 57.14
+	Hs
		1270389 HDAC2_HUMAN (1-488): 0: 707: 100.00		H2A1A_HUMAN (1-128): 1.35e-65: 206: 60.31
+	Hs
		1087070 HDAC2_HUMAN (1-488): 0: 707: 100.00		H2A2C_HUMAN (1-126): 7.57e-64: 201: 61.24
+	Mm
		1157843 HDAC4_MOUSE (1-377): 6.12e-133: 412: 23.89		H2AY_MOUSE (1-371): 8.65e-156: 444: 65.77
+	Hs
		1038643 HDAC1_HUMAN (1-443): 0: 642: 90.07		H2A1A_HUMAN (1-128): 1.35e-65: 206: 60.31
+	Mm
		1157741 HDAC4_MOUSE (1-377): 6.12e-133: 412: 23.89		H2AW_MOUSE (1-372): 8.13e-153: 436: 98.39
+	Hs
		1038464 HDAC1_HUMAN (1-443): 0: 642: 90.07		H2A2A_HUMAN (1-126): 4.27e-64: 201: 62.02
+	Hs
		391684 HDAC1_HUMAN (1-443): 0: 642: 90.07		H2A1B_HUMAN (1-126): 6.65e-64: 201: 60.47
+	Hs
		470374 HDAC1_HUMAN (1-443): 0: 642: 90.07		H2A1_HUMAN (1-126): 6.37e-64: 201: 60.47
+	Hs
		1115187 HDAC2_HUMAN (1-488): 0: 707: 100.00		PAR14_HUMAN (152-370): 1.01e-20: 96: 18.27
+	Hs
		177360 HDAC3_HUMAN (10-431): 0: 574: 58.26		H2A1A_HUMAN (1-128): 1.35e-65: 206: 60.31
+	At
		286877 HDA6_ARATH (1-467): 0: 578: 57.02		H2A3_ARATH (1-125): 1.06e-39: 139: 62.31
+	Hs
		177317 HDAC3_HUMAN (10-431): 0: 574: 58.26		PAR14_HUMAN (152-370): 1.01e-20: 96: 18.27
+	Sp
		140568 PHD1_SCHPO (7-411): 0: 519: 52.56		H2A2_SCHPO (3-123): 1.24e-39: 139: 64.52
+	Hs
		391948 HDAC6_HUMAN (11-363): 6.94e-102: 332: 24.04		H2A1B_HUMAN (1-126): 6.65e-64: 201: 60.47
+	Hs
		470596 HDAC6_HUMAN (11-363): 6.94e-102: 332: 24.04		H2A1_HUMAN (1-126): 6.37e-64: 201: 60.47
+	Sc
		392177 HDA1_YEAST (9-330): 1.24e-121: 373: 27.56		H2A1_YEAST (14-125): 3.15e-41: 143: 65.79
+	Sc
		392527 HDA1_YEAST (9-330): 1.24e-121: 373: 27.56		H2A2_YEAST (14-124): 2.55e-41: 143: 65.77