HitPredict

Interactor 1: EMSY (Q7Z589)
BRCA2-interacting transcriptional repressor EMSY
Gene: EMSY

Interactor 2: ASH2L (Q9UBL3)
Set1/Ash2 histone methyltransferase complex subunit ASH2 (ASH2-like protein)
Gene: ASH2L

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	34079125, 19131338
Identification Methods	proximity labelling technology, affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 1322 Hs			1 628
+	Hs
		1361927 TITIN_HUMAN (143-1231): 3.43e-45: 182: 12.44		ASH2L_HUMAN (1-628): 0: 790: 100.00
+	Hs
		1129771 MDC1_HUMAN (438-1262): 5.6e-24: 112: 12.00		ASH2L_HUMAN (1-628): 0: 790: 100.00
+	Hs
		1253880 SRCAP_HUMAN (238-1172): 4.26e-22: 106: 10.20		ASH2L_HUMAN (1-628): 0: 790: 100.00
+	Hs
		161520 KMT2D_HUMAN (321-1203): 2.65e-13: 77.6: 8.67		ASH2L_HUMAN (1-628): 0: 790: 100.00
+	Hs
		1338281 KMT2C_HUMAN (233-1113): 2.03e-10: 67.9: 9.71		ASH2L_HUMAN (1-628): 0: 790: 100.00
+	Mm
		1297308 KMT2C_MOUSE (288-1200): 1.9e-12: 74.5: 9.96		ASH2L_MOUSE (12-628): 0: 768: 96.11
+	Hs
		641342 TITIN_HUMAN (143-1231): 3.43e-45: 182: 12.44		RYR1_HUMAN (215-602): 1.07e-73: 260: 15.33
+	Dm
		1174428 Q9VLS7_DROME (154-1322): 1.91e-46: 185: 11.10		RYR_DROME (202-578): 2.14e-63: 230: 16.32
+	Hs
		1027555 HUWE1_HUMAN (272-823): 1.36e-29: 130: 13.01		HNRPU_HUMAN (301-600): 3.44e-52: 194: 20.74
+	Hs
		1280367 HUWE1_HUMAN (272-823): 1.36e-29: 130: 13.01		DDX1_HUMAN (355-623): 2.21e-51: 191: 19.27
+	Mm
		1028516 HUWE1_MOUSE (272-823): 3.28e-24: 113: 13.42		HNRL2_MOUSE (266-581): 2.47e-54: 199: 18.58
+	Hs
		1129610 MDC1_HUMAN (438-1262): 5.6e-24: 112: 12.00		HNRL2_HUMAN (270-581): 8.62e-54: 198: 19.41
+	Hs
		1280422 HUWE1_HUMAN (272-823): 1.36e-29: 130: 13.01		RANB9_HUMAN (346-580): 6.94e-47: 178: 22.18
+	Hs
		1027679 CIC_HUMAN (61-1063): 4.18e-14: 79.9: 9.62		HNRPU_HUMAN (301-600): 3.44e-52: 194: 20.74
+	Hs
		1363305 CIC_HUMAN (61-1063): 4.18e-14: 79.9: 9.62		DDX1_HUMAN (355-623): 2.21e-51: 191: 19.27
+	Hs
		1402311 MUC5B_HUMAN (91-1307): 5.88e-13: 76.3: 10.43		RANB9_HUMAN (346-580): 6.94e-47: 178: 22.18