HitPredict

Interactor 1: KMT2D (O14686)
Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2)
Gene: KMT2D

Interactor 2: ASH2L (Q9UBL3)
Set1/Ash2 histone methyltransferase complex subunit ASH2 (ASH2-like protein)
Gene: ASH2L

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.97 1.00 0.986

The method score is based on:

Property Details
Experiments 26886794, 31076518, 24981860, 34079125, 33961781, 23508102, 37974198, 16603732, 27563068, 30107592, 30604749, 32350066, 17925232, 24491801, 17178841, 12482968, unassigned3799
Identification Methods pull down, affinity chromatography technology, proximity labelling technology, anti bait coimmunoprecipitation, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains SET~SPRY
Common GO terms GO:0000976 - transcription cis-regulatory region binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0008270 - zinc ion binding
GO:0008284 - positive regulation of cell population proliferation
and 2 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

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Last updated: 11Aug2025