Interactor 1: ITCH (Q96J02)
E3 ubiquitin-protein ligase Itchy homolog (Itch) (EC 2.3.2.26) (Atrophin-1-interacting protein 4) (AIP4) (HECT-type E3 ubiquitin transferase Itchy homolog) (NFE2-associated polypeptide 1) (NAPP1)
Gene: ITCH

Interactor 2: ITCH (Q96J02)
E3 ubiquitin-protein ligase Itchy homolog (Itch) (EC 2.3.2.26) (Atrophin-1-interacting protein 4) (AIP4) (HECT-type E3 ubiquitin transferase Itchy homolog) (NFE2-associated polypeptide 1) (NAPP1)
Gene: ITCH

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.97 1.00 0.985

The method score is based on:

Property Details
Experiments 17996703, 11724934, 23146885, 17719543, 26949039, 19997087, 28475870, 28747490, 31578285, 18718449, 17592138, 17038327, 16446428, 22496338, 16055720, 24790097
Identification Methods enzymatic study, affinity chromatography technology, pull down
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains C2~C2, HECT~HECT, HECT~WW, WW~WW
Common GO terms GO:0001558 - regulation of cell growth
GO:0002669 - positive regulation of T cell anergy
GO:0002870 - T cell anergy
GO:0004842 - ubiquitin-protein transferase activity
GO:0005654 - nucleoplasm
and 46 others

more...

Homologous interactions 14

Homologous interactions

Color coding for hit scores

1 903
Hs

1 903
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Last updated: 15 Jul 2024