Interactor 1: ITCH (Q96J02)
E3 ubiquitin-protein ligase Itchy homolog (Itch) (EC 2.3.2.26) (Atrophin-1-interacting protein 4) (AIP4) (HECT-type E3 ubiquitin transferase Itchy homolog) (NFE2-associated polypeptide 1) (NAPP1)
Gene: ITCH
Interactor 2: ITCH (Q96J02)
E3 ubiquitin-protein ligase Itchy homolog (Itch) (EC 2.3.2.26) (Atrophin-1-interacting protein 4) (AIP4) (HECT-type E3 ubiquitin transferase Itchy homolog) (NFE2-associated polypeptide 1) (NAPP1)
Gene: ITCH
Species: Homo sapiens
Source: biogrid
Category: Small-scale
Confidence: High
Method score | Annotation score | Interaction score |
---|---|---|
0.97 | 1.00 | 0.985 |
The method score is based on:
Property | Details |
---|---|
Experiments | 17996703, 11724934, 23146885, 17719543, 26949039, 19997087, 28475870, 28747490, 31578285, 18718449, 17592138, 17038327, 16446428, 22496338, 16055720, 24790097 |
Identification Methods | enzymatic study, affinity chromatography technology, pull down |
Interaction Type | direct interaction, physical association |
The annotation score is based on:
Property | Details |
---|---|
Interacting Pfam domains | C2~C2, HECT~HECT, HECT~WW, WW~WW |
Common GO terms | GO:0001558 - regulation of cell growth GO:0002669 - positive regulation of T cell anergy GO:0002870 - T cell anergy GO:0004842 - ubiquitin-protein transferase activity GO:0005654 - nucleoplasm and 46 others more... |
Homologous interactions | 14 |
Homologous interactions
Color coding for hit scores
Service provided by Combinatics, Japan
Last updated: 15 Jul 2024