HitPredict

Interactor 1: AURKA (O14965)
Aurora kinase A (EC 2.7.11.1) (Aurora 2) (Aurora/IPL1-related kinase 1) (ARK-1) (Aurora-related kinase 1) (Breast tumor-amplified kinase) (Ipl1- and aurora-related kinase 1) (Serine/threonine-protein kinase 15) (Serine/threonine-protein kinase 6) (Serine/threonine-protein kinase Ayk1) (Serine/threonine-protein kinase aurora-A)
Gene: AURKA

Interactor 2: TACC3 (Q9Y6A5)
Transforming acidic coiled-coil-containing protein 3 (ERIC-1)
Gene: TACC3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.85 0.60 0.718

The method score is based on:

Property Details
Experiments 26186194, 28514442, 33961781, 32989298, 14602875
Identification Methods affinity chromatography technology, two hybrid, enzymatic study, anti tag coimmunoprecipitation
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0005829 - cytosol
GO:0007052 - mitotic spindle organization
GO:0051301 - cell division
GO:0072686 - mitotic spindle
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 403
Hs

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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024