HitPredict

Interactor 1: ELMO1 (Q8BPU7)
Engulfment and cell motility protein 1 (Protein ced-12 homolog)
Gene: ELMO1

Interactor 2: DOCK2 (Q8C3J5)
Dedicator of cytokinesis protein 2 (Protein Hch)
Gene: DOCK2

Species: Mus musculus

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.34	1.00	0.590

Property	Details
Experiments	15102471
Identification Methods	two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	DOCK_N~ELMO_CED12, DOCK_N~PH_12
Common GO terms	GO:0005085 - guanyl-nucleotide exchange factor activity GO:0005737 - cytoplasm GO:0030036 - actin cytoskeleton organization
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 727 Mm			1 1828
+	Hs
		1364447 ELMO1_HUMAN (1-727): 0: 1067: 99.59		DOCK2_HUMAN (1-1828): 0: 2468: 95.08
+	Hs
		1365425 ELMO2_HUMAN (1-724): 0: 985: 75.45		DOCK2_HUMAN (1-1828): 0: 2468: 95.08
+	Mm
		1297225 ELMO1_MOUSE (1-727): 0: 1067: 100.00		DOCK1_MOUSE (1-1781): 0: 2293: 58.71
+	Hs
		1122808 ELMO1_HUMAN (1-727): 0: 1067: 99.59		DOCK1_HUMAN (1-1781): 0: 2265: 59.09
+	Mm
		1296656 ELMO2_MOUSE (1-724): 0: 974: 74.08		DOCK1_MOUSE (1-1781): 0: 2293: 58.71
+	Hs
		1122813 ELMO2_HUMAN (1-724): 0: 985: 75.45		DOCK1_HUMAN (1-1781): 0: 2265: 59.09
+	Mm
		1297413 ELMO3_MOUSE (1-725): 0: 925: 52.47		DOCK1_MOUSE (1-1781): 0: 2293: 58.71
+	Hs
		1122811 ELMO3_HUMAN (1-727): 0: 934: 51.51		DOCK1_HUMAN (1-1781): 0: 2265: 59.09
+	Hs
		1364453 ELMO1_HUMAN (1-727): 0: 1067: 99.59		DOCK5_HUMAN (1-1744): 0: 2122: 56.12
+	Hs
		1395057 ELMO2_HUMAN (1-724): 0: 985: 75.45		DOCK5_HUMAN (1-1744): 0: 2122: 56.12
+	Hs
		1384667 ELMO3_HUMAN (1-727): 0: 934: 51.51		DOCK5_HUMAN (1-1744): 0: 2122: 56.12
+	Hs
		1316231 ELMO1_HUMAN (1-727): 0: 1067: 99.59		DOCK3_HUMAN (4-1659): 0: 1912: 38.16
+	Hs
		1323639 ELMO1_HUMAN (1-727): 0: 1067: 99.59		DOCK4_HUMAN (4-1612): 0: 1844: 38.71
+	Hs
		1316238 ELMO2_HUMAN (1-724): 0: 985: 75.45		DOCK3_HUMAN (4-1659): 0: 1912: 38.16
+	Hs
		1316236 ELMO3_HUMAN (1-727): 0: 934: 51.51		DOCK3_HUMAN (4-1659): 0: 1912: 38.16
+	Hs
		1323644 ELMO2_HUMAN (1-724): 0: 985: 75.45		DOCK4_HUMAN (4-1612): 0: 1844: 38.71
+	Hs
		1135243 ELMO2_HUMAN (1-724): 0: 985: 75.45		Q149N5_HUMAN (4-1612): 0: 1819: 37.52
+	Hs
		1323642 ELMO3_HUMAN (1-727): 0: 934: 51.51		DOCK4_HUMAN (4-1612): 0: 1844: 38.71
+	Dm
		84909 Q9VKB2_DROME (5-725): 0: 835: 45.92		B7Z0R2_DROME (4-1760): 0: 1859: 35.96
+	Hs
		1364449 ELMO1_HUMAN (1-727): 0: 1067: 99.59		DOC10_HUMAN (319-877): 5.85e-74: 277: 15.11