Protein: DOCK2
Dedicator of cytokinesis protein 2

Gene: DOCK2
Organism: Homo sapiens
Interactions: 69
UniProt ID: Q92608

Gene Ontology (top 5):
GO:0001766 - membrane raft polarization
GO:0001768 - establishment of T cell polarity
GO:0001771 - immunological synapse formation
GO:0002277 - myeloid dendritic cell activation involved in immune response
GO:0005085 - guanyl-nucleotide exchange factor activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

988576

RAC1
Ras-related C3 botulinum toxin substrate 1

3

20

Small-scale

0.834

High

581206

RAC2
Ras-related C3 botulinum toxin substrate 2

2

20

Small-scale

0.777

High

1364447

ELMO1
Engulfment and cell motility protein 1

2

20

Small-scale

0.767

High

685919

KRA59
Keratin-associated protein 5-9

3

16

High-throughput

0.675

High

950608

KR108
Keratin-associated protein 10-8

3

14

High-throughput

0.675

High

965803

HNRPK
Heterogeneous nuclear ribonucleoprotein K

3

1

High-throughput

0.675

High

1205910

MTUS2
Microtubule-associated tumor suppressor candidate 2

3

4

High-throughput

0.675

High

1230176

K1C40
Keratin, type I cytoskeletal 40

3

3

High-throughput

0.675

High

1365427

MDFI
MyoD family inhibitor

3

0

High-throughput

0.646

High

1277337

NT2NA
Notch homolog 2 N-terminal-like protein A

2

5

High-throughput

0.633

High

584571

VAV
Proto-oncogene vav

1

6

Small-scale

0.618

High

855914

CRKL
Crk-like protein

1

17

Small-scale

0.618

High

942784

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

7

High-throughput

0.618

High

1365425

ELMO2
Engulfment and cell motility protein 2

1

20

High-throughput

0.618

High

1219130

KHDR2
KH domain-containing, RNA-binding, signal transduction-associated protein 2

3

3

High-throughput

0.616

High

300449

KRT34
Keratin, type I cuticular Ha4

2

3

High-throughput

0.606

High

652375

TGM1
Protein-glutamine gamma-glutamyltransferase K

2

2

High-throughput

0.606

High

950353

KR107
Keratin-associated protein 10-7

2

14

High-throughput

0.606

High

1059706

KRA11
Keratin-associated protein 1-1

2

14

High-throughput

0.606

High

1146078

K1H1
Keratin, type I cuticular Ha1

2

3

High-throughput

0.606

High

1235801

KRA57
Keratin-associated protein 5-7

2

15

High-throughput

0.606

High

1236150

TEN4
Teneurin-4

2

3

High-throughput

0.606

High

1307427

KRA13
Keratin-associated protein 1-3

2

14

High-throughput

0.606

High

1365423

PCSK5
Proprotein convertase subtilisin/kexin type 5

2

1

High-throughput

0.606

High

1365428

CAR10
Caspase recruitment domain-containing protein 10

2

2

High-throughput

0.606

High

1365431

KRA93
Keratin-associated protein 9-3

2

11

High-throughput

0.606

High

1365434

KRA33
Keratin-associated protein 3-3

2

1

High-throughput

0.606

High

1365435

KRA31
Keratin-associated protein 3-1

2

1

High-throughput

0.606

High

70394

CRTP1
Cysteine-rich tail protein 1

2

0

High-throughput

0.580

High

949608

KR123
Keratin-associated protein 12-3

2

0

High-throughput

0.580

High

1365429

KR171
Keratin-associated protein 17-1

2

0

High-throughput

0.580

High

783358

TRI23
E3 ubiquitin-protein ligase TRIM23

1

2

High-throughput

0.573

High

950848

KR109
Keratin-associated protein 10-9

1

15

High-throughput

0.573

High

1095735

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

1

2

High-throughput

0.573

High

1365430

KRA94
Keratin-associated protein 9-4

1

11

High-throughput

0.573

High

1365432

KRA92
Keratin-associated protein 9-2

1

11

High-throughput

0.573

High

1365433

KRA42
Keratin-associated protein 4-2

1

11

High-throughput

0.573

High

65119

GG6L9
Golgin subfamily A member 6-like protein 9

2

3

High-throughput

0.553

High

284705

KHDR3
KH domain-containing, RNA-binding, signal transduction-associated protein 3

2

3

High-throughput

0.553

High

885350

HXA1
Homeobox protein Hox-A1

2

3

High-throughput

0.553

High

1365436

PKHF2
Pleckstrin homology domain-containing family F member 2

2

3

High-throughput

0.553

High

180563

PLS1
Phospholipid scramblase 1

1

0

High-throughput

0.549

High

332557

CCDB1
Cyclin-D1-binding protein 1

1

0

High-throughput

0.549

High

178093

FYB1
FYN-binding protein 1

1

0

Small-scale

0.546

High

517075

NT2NC
Notch homolog 2 N-terminal-like protein C

1

5

High-throughput

0.515

High

161067

ADA10
Disintegrin and metalloproteinase domain-containing protein 10

1

2

Small-scale

0.501

High

1097219

PAK2
Serine/threonine-protein kinase PAK 2

1

2

Small-scale

0.501

High

530149

TAU
Microtubule-associated protein tau

1

0

High-throughput

0.493

High

1365426

LITAF
Lipopolysaccharide-induced tumor necrosis factor-alpha factor

1

0

High-throughput

0.493

High

1111148

SNW1
SNW domain-containing protein 1

1

1

High-throughput

0.489

High

592

NBPFJ
NBPF family member NBPF19

1

1

High-throughput

0.481

High

949756

KR101
Keratin-associated protein 10-1

1

15

High-throughput

0.481

High

949955

KR103
Keratin-associated protein 10-3

1

15

High-throughput

0.481

High

223223

PRC1
Protein regulator of cytokinesis 1

1

1

High-throughput

0.479

High

535362

BIP
Endoplasmic reticulum chaperone BiP

1

4

High-throughput

0.479

High

606956

CEBPB
CCAAT/enhancer-binding protein beta

1

3

High-throughput

0.479

High

663821

LAMA2
Laminin subunit alpha-2

1

1

High-throughput

0.479

High

701880

ABCD3
ATP-binding cassette sub-family D member 3

1

1

High-throughput

0.479

High

888221

MCM2
DNA replication licensing factor MCM2

1

1

High-throughput

0.479

High

1227177

A16L1
Autophagy-related protein 16-1

1

2

High-throughput

0.479

High

353471

AGR2
Anterior gradient protein 2 homolog

1

0

High-throughput

0.458

High

635904

CD3Z
T-cell surface glycoprotein CD3 zeta chain

1

0

Small-scale

0.458

High

719250

MPIP2
M-phase inducer phosphatase 2

1

0

High-throughput

0.458

High

928504

TERF1
Telomeric repeat-binding factor 1

1

0

High-throughput

0.458

High

1365424

DCPS
m7GpppX diphosphatase

1

0

High-throughput

0.458

High

1059907

KHDR1
KH domain-containing, RNA-binding, signal transduction-associated protein 1

1

3

Small-scale

0.408

High

887066

CEBPA
CCAAT/enhancer-binding protein alpha

1

3

High-throughput

0.373

High

1365437

Q9P1N4
PRO1359

1

0

High-throughput

0.268

Low

1226483

DCA15
DDB1- and CUL4-associated factor 15

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025