Protein: PCSK5
Proprotein convertase subtilisin/kexin type 5 (EC 3.4.21.-) (Proprotein convertase 5) (PC5) (Proprotein convertase 6) (PC6) (hPC6) (Subtilisin/kexin-like protease PC5)

Gene: PCSK5
Organism: Homo sapiens
Interactions: 106
UniProt ID: Q92824

Gene Ontology (top 5):
GO:0001822 - kidney development
GO:0002001 - renin secretion into blood stream
GO:0004175 - endopeptidase activity
GO:0004252 - serine-type endopeptidase activity
GO:0005576 - extracellular region

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1069955

PTPRK
Receptor-type tyrosine-protein phosphatase kappa

3

8

High-throughput

0.861

High

664188

PCSK6
Proprotein convertase subtilisin/kexin type 6

2

20

High-throughput

0.783

High

1219891

TRI42
Tripartite motif-containing protein 42

2

10

High-throughput

0.700

High

685280

CEAM8
Carcinoembryonic antigen-related cell adhesion molecule 8

1

7

High-throughput

0.691

High

992692

LRP1
Prolow-density lipoprotein receptor-related protein 1

1

13

High-throughput

0.691

High

1189886

NUFP2
FMR1-interacting protein NUFIP2

3

2

High-throughput

0.675

High

968891

NAAA
N-acylethanolamine-hydrolyzing acid amidase

3

1

High-throughput

0.667

High

976249

UPAR
Urokinase plasminogen activator surface receptor

3

1

High-throughput

0.667

High

1271392

GPHA2
Glycoprotein hormone alpha-2

3

1

High-throughput

0.667

High

1189384

NT2NA
Notch homolog 2 N-terminal-like protein A

2

19

High-throughput

0.633

High

447631

CEL3A
Chymotrypsin-like elastase family member 3A

2

4

High-throughput

0.628

High

533030

PRG2
Bone marrow proteoglycan

2

13

High-throughput

0.628

High

1231562

LYPD1
Ly6/PLAUR domain-containing protein 1

2

2

High-throughput

0.628

High

1271407

PRG3
Proteoglycan 3

2

12

High-throughput

0.628

High

158966

NCTR3
Natural cytotoxicity triggering receptor 3

1

4

High-throughput

0.618

High

642127

KRA59
Keratin-associated protein 5-9

3

10

High-throughput

0.616

High

889611

KR108
Keratin-associated protein 10-8

3

9

High-throughput

0.616

High

208388

SPY1
Protein sprouty homolog 1

2

3

High-throughput

0.606

High

567868

HXB9
Homeobox protein Hox-B9

2

4

High-throughput

0.606

High

1017508

PO4F2
POU domain, class 4, transcription factor 2

2

3

High-throughput

0.606

High

1166947

ATL4
ADAMTS-like protein 4

2

6

High-throughput

0.606

High

1271395

TRAF4
TNF receptor-associated factor 4

2

11

High-throughput

0.606

High

180742

PA2GX
Group 10 secretory phospholipase A2

2

0

High-throughput

0.602

High

1165333

LYPD4
Ly6/PLAUR domain-containing protein 4

2

0

High-throughput

0.602

High

1271408

INSL5
Insulin-like peptide INSL5

2

0

High-throughput

0.602

High

686501

OTX1
Homeobox protein OTX1

2

0

High-throughput

0.580

High

1267932

DOCK2
Dedicator of cytokinesis protein 2

2

0

High-throughput

0.580

High

838178

MEOX2
Homeobox protein MOX-2

2

2

High-throughput

0.578

High

274273

STK16
Serine/threonine-protein kinase 16

1

2

High-throughput

0.573

High

829962

HXA1
Homeobox protein Hox-A1

2

6

High-throughput

0.553

High

887406

KR122
Keratin-associated protein 12-2

2

7

High-throughput

0.553

High

889852

KR109
Keratin-associated protein 10-9

2

9

High-throughput

0.553

High

991637

KRA11
Keratin-associated protein 1-1

2

9

High-throughput

0.553

High

993527

TLE5
TLE family member 5

2

1

High-throughput

0.553

High

1075948

PCH2
Pachytene checkpoint protein 2 homolog

2

2

High-throughput

0.553

High

1174078

UBP54
Inactive ubiquitin carboxyl-terminal hydrolase 54

2

4

High-throughput

0.553

High

1217783

ZN547
Zinc finger protein 547

2

14

High-throughput

0.553

High

1236813

ZN655
Zinc finger protein 655

2

11

High-throughput

0.553

High

1267466

NR4A3
Nuclear receptor subfamily 4 group A member 3

2

6

High-throughput

0.553

High

1271389

ZN837
Zinc finger protein 837

2

7

High-throughput

0.553

High

1271391

TRIB3
Tribbles homolog 3

2

3

High-throughput

0.553

High

1271396

LCE3D
Late cornified envelope protein 3D

2

1

High-throughput

0.553

High

1271397

KRA32
Keratin-associated protein 3-2

2

1

High-throughput

0.553

High

1271398

KRA31
Keratin-associated protein 3-1

2

1

High-throughput

0.553

High

211391

PI15
Peptidase inhibitor 15

1

3

High-throughput

0.536

High

295876

LY6H
Lymphocyte antigen 6H

1

1

High-throughput

0.536

High

319615

LY86
Lymphocyte antigen 86

1

2

High-throughput

0.536

High

474758

CFC1
Cryptic protein

1

5

High-throughput

0.536

High

486303

CCL3
C-C motif chemokine 3

1

2

High-throughput

0.536

High

873730

SLUR1
Secreted Ly-6/uPAR-related protein 1

1

2

High-throughput

0.536

High

964683

IL5RA
Interleukin-5 receptor subunit alpha

1

8

High-throughput

0.536

High

1166387

IGFL3
Insulin growth factor-like family member 3

1

5

High-throughput

0.536

High

1217153

HDBP1
Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

1

4

High-throughput

0.536

High

1262416

CA054
Uncharacterized protein C1orf54

1

2

High-throughput

0.536

High

1271400

CST9L
Cystatin-9-like

1

4

High-throughput

0.536

High

1271401

SDF2L
Stromal cell-derived factor 2-like protein 1

1

4

High-throughput

0.536

High

1271409

ST14
Suppressor of tumorigenicity 14 protein

1

7

High-throughput

0.536

High

280439

GLRX3
Glutaredoxin-3

1

5

High-throughput

0.523

High

889353

KR107
Keratin-associated protein 10-7

1

14

High-throughput

0.523

High

1271394

KR412
Keratin-associated protein 4-12

1

7

High-throughput

0.523

High

484678

NT2NC
Notch homolog 2 N-terminal-like protein C

1

19

High-throughput

0.515

High

328276

BY55
CD160 antigen

1

0

High-throughput

0.513

High

1271399

CAD23
Cadherin-23

1

0

High-throughput

0.513

High

132337

CAC1A
Voltage-dependent P/Q-type calcium channel subunit alpha-1A

1

4

High-throughput

0.508

High

599699

TNAP3
Tumor necrosis factor alpha-induced protein 3

1

4

High-throughput

0.489

High

1030742

SLAF1
Signaling lymphocytic activation molecule

1

9

High-throughput

0.489

High

1100776

CL12B
C-type lectin domain family 12 member B

1

8

High-throughput

0.489

High

1271387

TANK
TRAF family member-associated NF-kappa-B activator

1

2

High-throughput

0.489

High

1271388

SPSB4
SPRY domain-containing SOCS box protein 4

1

8

High-throughput

0.489

High

1271405

DNJB9
DnaJ homolog subfamily B member 9

1

9

High-throughput

0.489

High

1271406

FBX2
F-box only protein 2

1

9

High-throughput

0.489

High

1271410

NEMO
NF-kappa-B essential modulator

1

1

High-throughput

0.489

High

1259563

SRB4D
Scavenger receptor cysteine-rich domain-containing group B protein

1

5

High-throughput

0.481

High

1151160

Q6FHY5
MEOX2 protein

1

2

High-throughput

0.470

High

1155947

Q6NSM0
NR1D2 protein

1

8

High-throughput

0.470

High

869502

ATN1
Atrophin-1

1

5

High-throughput

0.464

High

888951

KR103
Keratin-associated protein 10-3

1

9

High-throughput

0.439

High

1061354

NR1D2
Nuclear receptor subfamily 1 group D member 2

1

4

High-throughput

0.439

High

1135568

LCE3A
Late cornified envelope protein 3A

1

1

High-throughput

0.439

High

1133539

LCE3C
Late cornified envelope protein 3C

3

0

High-throughput

0.352

High

67266

CRTP1
Cysteine-rich tail protein 1

2

0

High-throughput

0.316

High

67987

VGLL3
Transcription cofactor vestigial-like protein 3

2

0

High-throughput

0.316

High

207362

FRS3
Fibroblast growth factor receptor substrate 3

2

0

High-throughput

0.316

High

311958

SYFM
Phenylalanine--tRNA ligase, mitochondrial

2

0

High-throughput

0.316

High

836425

MCSP
Sperm mitochondrial-associated cysteine-rich protein

2

0

High-throughput

0.316

High

973611

CREB5
Cyclic AMP-responsive element-binding protein 5

2

0

High-throughput

0.316

High

1012294

INCA1
Protein INCA1

2

0

High-throughput

0.316

High

1109085

KR192
Keratin-associated protein 19-2

2

0

High-throughput

0.316

High

1110255

KR133
Keratin-associated protein 13-3

2

0

High-throughput

0.316

High

1134541

LCE1D
Late cornified envelope protein 1D

2

0

High-throughput

0.316

High

1134628

LCE1F
Late cornified envelope protein 1F

2

0

High-throughput

0.316

High

1135706

LCE2C
Late cornified envelope protein 2C

2

0

High-throughput

0.316

High

1160223

CV039
Synaptic plasticity regulator PANTS

2

0

High-throughput

0.316

High

1216008

KR111
Keratin-associated protein 11-1

2

0

High-throughput

0.316

High

1244966

DBF4B
Protein DBF4 homolog B

2

0

High-throughput

0.316

High

1262151

CQ050
Uncharacterized protein C17orf50

2

0

High-throughput

0.316

High

1262180

TEKT4
Tektin-4

2

0

High-throughput

0.316

High

1271390

GUCD1
Protein GUCD1

2

0

High-throughput

0.316

High

1271393

MDFI
MyoD family inhibitor

2

0

High-throughput

0.316

High

1271402

PLS4
Phospholipid scramblase 4

2

0

High-throughput

0.316

High

1271403

SHFL
Shiftless antiviral inhibitor of ribosomal frameshifting protein

2

0

High-throughput

0.316

High

1271404

F86C1
Putative protein FAM86C1P

2

0

High-throughput

0.316

High

1268417

APBP2
Amyloid protein-binding protein 2

1

0

High-throughput

0.282

High

1075523

TRADD
Tumor necrosis factor receptor type 1-associated DEATH domain protein

1

0

High-throughput

0.279

Low

593

NBPFJ
Neuroblastoma breakpoint family member 19

1

0

High-throughput

0.251

Low

1235094

CCD33
Coiled-coil domain-containing protein 33

1

0

High-throughput

0.251

Low


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Last updated: 15 Jul 2024