Protein: DOCK3
Dedicator of cytokinesis protein 3 (Modifier of cell adhesion) (Presenilin-binding protein) (PBP)

Gene: DOCK3
Organism: Homo sapiens
Interactions: 60
UniProt ID: Q8IZD9

Gene Ontology (top 5):
GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0005096 - GTPase activator activity
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1316231

ELMO1
Engulfment and cell motility protein 1

6

20

Small-scale

0.942

High

1316238

ELMO2
Engulfment and cell motility protein 2

3

20

High-throughput

0.839

High

1316236

ELMO3
Engulfment and cell motility protein 3

2

20

High-throughput

0.811

High

1316229

DOCK4
Dedicator of cytokinesis protein 4

1

12

High-throughput

0.691

High

1127356

CASL
Enhancer of filamentation 1

1

7

Small-scale

0.665

High

988515

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.647

High

362317

ABL1
Tyrosine-protein kinase ABL1

1

8

High-throughput

0.618

High

440626

FYN
Tyrosine-protein kinase Fyn

1

8

High-throughput

0.618

High

557376

SRC
Proto-oncogene tyrosine-protein kinase Src

1

8

High-throughput

0.618

High

594044

NCK1
SH2/SH3 adapter protein NCK1

1

15

High-throughput

0.618

High

699801

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

6

High-throughput

0.618

High

855680

CRK
Adapter molecule crk

1

20

High-throughput

0.618

High

987765

GRB2
Growth factor receptor-bound protein 2

1

18

High-throughput

0.618

High

1092736

RHG05
Rho GTPase-activating protein 5

2

5

High-throughput

0.594

High

175113

SC16A
Protein transport protein Sec16A

2

5

High-throughput

0.571

High

184473

SURF4
Surfeit locus protein 4

2

1

High-throughput

0.571

High

701862

ABCD3
ATP-binding cassette sub-family D member 3

2

2

High-throughput

0.571

High

938236

SEC13
Protein SEC13 homolog

2

3

High-throughput

0.571

High

1122104

UBP2L
Ubiquitin-associated protein 2-like

2

9

High-throughput

0.571

High

1156145

ZYX
Zyxin

2

1

High-throughput

0.571

High

1316232

GCN1
Stalled ribosome sensor GCN1

2

4

High-throughput

0.571

High

1316241

TRAF4
TNF receptor-associated factor 4

2

2

High-throughput

0.571

High

885330

HXA1
Homeobox protein Hox-A1

2

4

High-throughput

0.553

High

1316244

PKHF2
Pleckstrin homology domain-containing family F member 2

2

3

High-throughput

0.553

High

566751

PDIA4
Protein disulfide-isomerase A4

2

3

High-throughput

0.549

High

210988

PSMD3
26S proteasome non-ATPase regulatory subunit 3

2

0

High-throughput

0.547

High

520912

HLAC
HLA class I histocompatibility antigen, C alpha chain

2

0

High-throughput

0.547

High

1316233

AKAP1
A-kinase anchor protein 1, mitochondrial

2

0

High-throughput

0.547

High

1316242

REPI1
DNA-binding protein REPIN1

2

0

High-throughput

0.547

High

1316249

HACD3
Very-long-chain

2

0

High-throughput

0.547

High

600332

ZNF24
Zinc finger protein 24

2

1

High-throughput

0.521

High

1316243

ZN768
Zinc finger protein 768

2

2

High-throughput

0.521

High

1316250

DHCR7
7-dehydrocholesterol reductase

2

2

High-throughput

0.521

High

1316230

RSPH1
Radial spoke head 1 homolog

1

0

High-throughput

0.518

High

1316246

DDX21
Nucleolar RNA helicase 2

1

4

High-throughput

0.515

High

1316235

AIDA
Axin interactor, dorsalization-associated protein

1

0

High-throughput

0.513

High

1316240

TREX2
Three prime repair exonuclease 2

1

0

High-throughput

0.513

High

1316251

TBC24
TBC1 domain family member 24

1

0

High-throughput

0.513

High

1006536

SRPK2
SRSF protein kinase 2

1

7

High-throughput

0.501

High

404211

GCR
Glucocorticoid receptor

1

8

Small-scale

0.481

High

173050

XPO1
Exportin-1

1

5

High-throughput

0.479

High

189321

NMDE4
Glutamate receptor ionotropic, NMDA 2D

1

3

Small-scale

0.479

High

211362

RFOX2
RNA binding protein fox-1 homolog 2

1

4

High-throughput

0.479

High

1119966

CIRBP
Cold-inducible RNA-binding protein

1

1

High-throughput

0.479

High

1291058

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

2

High-throughput

0.479

High

1316237

P5CR2
Pyrroline-5-carboxylate reductase 2

1

2

High-throughput

0.479

High

1316247

SIR5
NAD-dependent protein deacylase sirtuin-5, mitochondrial

1

4

High-throughput

0.479

High

1316252

MAGD2
Melanoma-associated antigen D2

1

3

High-throughput

0.479

High

1161936

H31T
Histone H3.1t

1

3

High-throughput

0.470

High

724778

METK2
S-adenosylmethionine synthase isoform type-2

1

0

High-throughput

0.458

High

960167

RL26
Large ribosomal subunit protein uL24

1

0

High-throughput

0.458

High

1316239

YMEL1
ATP-dependent zinc metalloprotease YME1L1

1

2

High-throughput

0.437

High

1316248

GAR1
H/ACA ribonucleoprotein complex subunit 1

1

1

High-throughput

0.437

High

1059892

KHDR1
KH domain-containing, RNA-binding, signal transduction-associated protein 1

1

3

Small-scale

0.408

High

939806

ATPK
ATP synthase F(0) complex subunit f, mitochondrial

2

0

High-throughput

0.298

High

1192057

TIM50
Mitochondrial import inner membrane translocase subunit TIM50

2

0

High-throughput

0.298

High

1316234

CCD47
PAT complex subunit CCDC47

2

0

High-throughput

0.298

High

1316245

RM47
Large ribosomal subunit protein uL29m

2

0

High-throughput

0.298

High

1316228

H6ST3
Heparan-sulfate 6-O-sulfotransferase 3

1

0

High-throughput

0.279

Low

1316253

HS3S4
Heparan sulfate glucosamine 3-O-sulfotransferase 4

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025