HitPredict

Interactor 1: DOCK4 (Q8N1I0)
Dedicator of cytokinesis protein 4
Gene: DOCK4

Interactor 2: ELMO3 (Q96BJ8)
Engulfment and cell motility protein 3
Gene: ELMO3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	DOCK_N~ELMO_CED12, DOCK_N~PH_12
Common GO terms	GO:0005737 - cytoplasm GO:0017124 - SH3 domain binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1966 Hs			1 720
+	Hs
		1323639 DOCK4_HUMAN (1-1966): 0: 2071: 100.00		ELMO1_HUMAN (1-716): 0: 943: 51.51
+	Hs
		1323644 DOCK4_HUMAN (1-1966): 0: 2071: 100.00		ELMO2_HUMAN (1-715): 0: 924: 50.28
+	Hs
		1135243 Q149N5_HUMAN (1-1966): 0: 2034: 97.61		ELMO2_HUMAN (1-715): 0: 924: 50.28
+	Hs
		1316236 DOCK3_HUMAN (1-1964): 0: 1906: 54.60		ELMO3_HUMAN (1-720): 0: 960: 100.00
+	Hs
		1316231 DOCK3_HUMAN (1-1964): 0: 1906: 54.60		ELMO1_HUMAN (1-716): 0: 943: 51.51
+	Hs
		1316238 DOCK3_HUMAN (1-1964): 0: 1906: 54.60		ELMO2_HUMAN (1-715): 0: 924: 50.28
+	Mm
		1297413 DOCK1_MOUSE (2-1795): 0: 1797: 36.16		ELMO3_MOUSE (1-720): 0: 949: 90.83
+	Mm
		1297225 DOCK1_MOUSE (2-1795): 0: 1797: 36.16		ELMO1_MOUSE (1-716): 0: 944: 51.51
+	Hs
		1122811 DOCK1_HUMAN (2-1792): 0: 1770: 36.51		ELMO3_HUMAN (1-720): 0: 960: 100.00
+	Hs
		1122808 DOCK1_HUMAN (2-1792): 0: 1770: 36.51		ELMO1_HUMAN (1-716): 0: 943: 51.51
+	Mm
		1296656 DOCK1_MOUSE (2-1795): 0: 1797: 36.16		ELMO2_MOUSE (1-715): 0: 913: 49.46
+	Hs
		1122813 DOCK1_HUMAN (2-1792): 0: 1770: 36.51		ELMO2_HUMAN (1-715): 0: 924: 50.28
+	Hs
		1364447 DOCK2_HUMAN (2-1771): 0: 1745: 35.38		ELMO1_HUMAN (1-716): 0: 943: 51.51
+	Hs
		1384667 DOCK5_HUMAN (2-1790): 0: 1715: 34.82		ELMO3_HUMAN (1-720): 0: 960: 100.00
+	Hs
		1365425 DOCK2_HUMAN (2-1771): 0: 1745: 35.38		ELMO2_HUMAN (1-715): 0: 924: 50.28
+	Mm
		1297227 DOCK2_MOUSE (2-1771): 0: 1718: 35.68		ELMO1_MOUSE (1-716): 0: 944: 51.51
+	Hs
		1364453 DOCK5_HUMAN (2-1790): 0: 1715: 34.82		ELMO1_HUMAN (1-716): 0: 943: 51.51
+	Hs
		1395057 DOCK5_HUMAN (2-1790): 0: 1715: 34.82		ELMO2_HUMAN (1-715): 0: 924: 50.28
+	Dm
		1470411 Q9VCH4_DROME (5-1856): 0: 1609: 29.05		Q9VKB2_DROME (5-714): 0: 810: 42.21
+	Dm
		84909 B7Z0R2_DROME (1-1746): 0: 1574: 38.15		Q9VKB2_DROME (5-714): 0: 810: 42.21