Protein: DOCK5
Dedicator of cytokinesis protein 5

Gene: DOCK5
Organism: Homo sapiens
Interactions: 117
UniProt ID: Q9H7D0

Gene Ontology (top 5):
GO:0002102 - podosome
GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0005096 - GTPase activator activity
GO:0005737 - cytoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1364453

ELMO1
Engulfment and cell motility protein 1

6

20

Small-scale

0.942

High

987946

GRB2
Growth factor receptor-bound protein 2

6

20

High-throughput

0.935

High

855757

CRK
Adapter molecule crk

5

19

Small-scale

0.915

High

1239443

ANR54
Ankyrin repeat domain-containing protein 54

4

6

High-throughput

0.892

High

1395057

ELMO2
Engulfment and cell motility protein 2

4

20

High-throughput

0.892

High

1122819

DOCK1
Dedicator of cytokinesis protein 1

3

13

High-throughput

0.852

High

855940

CRKL
Crk-like protein

2

18

High-throughput

0.811

High

1052378

RN5A
2-5A-dependent ribonuclease

2

4

High-throughput

0.811

High

1201897

PKHG4
Puratrophin-1

2

2

High-throughput

0.811

High

1323077

AHI1
Jouberin

2

7

High-throughput

0.811

High

1384667

ELMO3
Engulfment and cell motility protein 3

2

20

High-throughput

0.811

High

1420059

KPCD2
Serine/threonine-protein kinase D2

2

2

High-throughput

0.811

High

581295

RAC2
Ras-related C3 botulinum toxin substrate 2

1

20

High-throughput

0.691

High

1085112

KIF1A
Kinesin-like protein KIF1A

1

2

High-throughput

0.691

High

1364877

P55G
Phosphatidylinositol 3-kinase regulatory subunit gamma

1

15

High-throughput

0.691

High

218785

TGON2
Trans-Golgi network integral membrane protein 2

2

6

High-throughput

0.628

High

288023

MYCB2
E3 ubiquitin-protein ligase MYCBP2

2

4

High-throughput

0.628

High

322999

UBP19
Ubiquitin carboxyl-terminal hydrolase 19

2

2

High-throughput

0.628

High

839175

PK3CB
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform

2

1

High-throughput

0.628

High

1108713

TBB3
Tubulin beta-3 chain

2

1

High-throughput

0.628

High

1245014

SPSB3
SPRY domain-containing SOCS box protein 3

2

13

High-throughput

0.628

High

1245064

TRI65
E3 ubiquitin-protein ligase TRIM65

2

2

High-throughput

0.628

High

1245334

WDR59
GATOR2 complex protein WDR59

2

3

High-throughput

0.628

High

1339852

PJA1
E3 ubiquitin-protein ligase Praja-1

2

2

High-throughput

0.628

High

1383783

TTC28
Tetratricopeptide repeat protein 28

2

1

High-throughput

0.628

High

1390481

DDX11
ATP-dependent DNA helicase DDX11

2

1

High-throughput

0.628

High

1416501

FANCJ
Fanconi anemia group J protein

2

1

High-throughput

0.628

High

1433416

TBB1
Tubulin beta-1 chain

2

1

High-throughput

0.628

High

1435207

BCAS3
BCAS3 microtubule associated cell migration factor

2

1

High-throughput

0.628

High

1435658

ZHX2
Zinc fingers and homeoboxes protein 2

2

1

High-throughput

0.628

High

1312259

MIRO2
Mitochondrial Rho GTPase 2

1

20

High-throughput

0.618

High

374932

RASH
GTPase HRas

1

11

High-throughput

0.618

High

375958

RASK
GTPase KRas

1

15

High-throughput

0.618

High

988712

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.618

High

1015791

RHOG
Rho-related GTP-binding protein RhoG

1

20

High-throughput

0.618

High

155878

DPYL4
Dihydropyrimidinase-related protein 4

2

0

High-throughput

0.602

High

899675

AT1A2
Sodium/potassium-transporting ATPase subunit alpha-2

2

0

High-throughput

0.602

High

1129302

BLTP2
Bridge-like lipid transfer protein family member 2

2

0

High-throughput

0.602

High

1139388

RB3GP
Rab3 GTPase-activating protein catalytic subunit

2

0

High-throughput

0.602

High

1336174

SMG8
Nonsense-mediated mRNA decay factor SMG8

2

0

High-throughput

0.602

High

1360620

MADD
MAP kinase-activating death domain protein

2

0

High-throughput

0.602

High

1389327

MOCOS
Molybdenum cofactor sulfurase

2

0

High-throughput

0.602

High

1406571

METH
Methionine synthase

2

0

High-throughput

0.602

High

1435653

MKS1
Tectonic-like complex member MKS1

2

0

High-throughput

0.602

High

468812

HS90B
Heat shock protein HSP 90-beta

2

4

High-throughput

0.584

High

1385171

ATG2B
Autophagy-related protein 2 homolog B

2

1

High-throughput

0.574

High

347330

BAG2
BAG family molecular chaperone regulator 2

1

1

High-throughput

0.536

High

537920

HSP7C
Heat shock cognate 71 kDa protein

1

1

High-throughput

0.536

High

760503

SDC2
Syndecan-2

1

1

High-throughput

0.536

High

760850

GLYC
Serine hydroxymethyltransferase, cytosolic

1

1

High-throughput

0.536

High

774627

BASI
Basigin

1

2

High-throughput

0.536

High

909186

NEK4
Serine/threonine-protein kinase Nek4

1

3

High-throughput

0.536

High

1051686

NMDZ1
Glutamate receptor ionotropic, NMDA 1

1

3

High-throughput

0.536

High

1191983

TBB8
Tubulin beta-8 chain

1

1

High-throughput

0.536

High

1382382

SPSB4
SPRY domain-containing SOCS box protein 4

1

13

High-throughput

0.536

High

1383858

EFMT3
EEF1A lysine methyltransferase 3

1

3

High-throughput

0.536

High

1404403

CDC5L
Cell division cycle 5-like protein

1

1

High-throughput

0.536

High

1405979

SPSB2
SPRY domain-containing SOCS box protein 2

1

10

High-throughput

0.536

High

1435654

HDAC6
Protein deacetylase HDAC6

1

3

High-throughput

0.536

High

927550

ATX1
Ataxin-1

1

0

High-throughput

0.518

High

144318

ACACB
Acetyl-CoA carboxylase 2

1

0

High-throughput

0.513

High

182774

GP182
G-protein coupled receptor 182

1

0

High-throughput

0.513

High

997140

TBA4A
Tubulin alpha-4A chain

1

0

High-throughput

0.513

High

1149375

STIL
SCL-interrupting locus protein

1

0

High-throughput

0.513

High

1159234

SGCA
Alpha-sarcoglycan

1

0

High-throughput

0.513

High

1234620

P4R3A
Serine/threonine-protein phosphatase 4 regulatory subunit 3A

1

0

High-throughput

0.513

High

1338253

WDR19
WD repeat-containing protein 19

1

0

High-throughput

0.513

High

1390538

CDCA5
Sororin

1

0

High-throughput

0.513

High

1399614

OPALI
Opalin

1

0

High-throughput

0.513

High

1218316

LRCH2
Leucine-rich repeat and calponin homology domain-containing protein 2

1

12

High-throughput

0.489

High

1281230

VP13B
Intermembrane lipid transfer protein VPS13B

1

1

High-throughput

0.489

High

1409714

MICU1
Calcium uptake protein 1, mitochondrial

1

2

High-throughput

0.489

High

1435656

VSIG4
V-set and immunoglobulin domain-containing protein 4

1

2

High-throughput

0.489

High

331331

KI20A
Kinesin-like protein KIF20A

1

6

High-throughput

0.479

High

424268

S10A8
Protein S100-A8

1

4

High-throughput

0.479

High

445068

S10A9
Protein S100-A9

1

5

High-throughput

0.479

High

461941

HS90A
Heat shock protein HSP 90-alpha

1

4

High-throughput

0.479

High

941843

ARL4C
ADP-ribosylation factor-like protein 4C

1

3

High-throughput

0.479

High

1095460

AAPK1
5'-AMP-activated protein kinase catalytic subunit alpha-1

1

1

High-throughput

0.479

High

1114313

CUL3
Cullin-3

1

6

High-throughput

0.479

High

1217199

RIF1
Telomere-associated protein RIF1

1

2

High-throughput

0.479

High

1220803

RN123
E3 ubiquitin-protein ligase RNF123

1

2

High-throughput

0.479

High

1255561

TRI67
Tripartite motif-containing protein 67

1

10

High-throughput

0.479

High

1325525

FBXW8
F-box/WD repeat-containing protein 8

1

5

High-throughput

0.479

High

1435655

INTU
Protein inturned

1

0

High-throughput

0.458

High

262309

SCN2B
Sodium channel regulatory subunit beta-2

1

4

High-throughput

0.445

High

388298

GLPA
Glycophorin-A

1

2

High-throughput

0.445

High

587807

DESP
Desmoplakin

1

3

High-throughput

0.445

High

610893

TCPA
T-complex protein 1 subunit alpha

1

3

High-throughput

0.445

High

718001

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

1

2

High-throughput

0.445

High

718179

2AAB
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform

1

2

High-throughput

0.445

High

821576

TCPZ
T-complex protein 1 subunit zeta

1

3

High-throughput

0.445

High

876173

TCPE
T-complex protein 1 subunit epsilon

1

5

High-throughput

0.445

High

882164

TCPG
T-complex protein 1 subunit gamma

1

4

High-throughput

0.445

High

899238

TCPQ
T-complex protein 1 subunit theta

1

6

High-throughput

0.445

High

899585

TCPD
T-complex protein 1 subunit delta

1

4

High-throughput

0.445

High

994378

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

1

2

High-throughput

0.445

High

1007285

TCPB
T-complex protein 1 subunit beta

1

4

High-throughput

0.445

High

1048389

ACVR1
Activin receptor type-1

1

2

High-throughput

0.445

High

1057699

TNR9
Tumor necrosis factor receptor superfamily member 9

1

2

High-throughput

0.445

High

1407575

TCPH
T-complex protein 1 subunit eta

1

4

High-throughput

0.445

High

897976

CDK9
Cyclin-dependent kinase 9

1

1

High-throughput

0.437

High

1250199

LRC31
Leucine-rich repeat-containing protein 31

1

4

High-throughput

0.437

High

1403731

YMEL1
ATP-dependent zinc metalloprotease YME1L1

1

1

High-throughput

0.437

High

1435657

TRRAP
Transformation/transcription domain-associated protein

1

1

High-throughput

0.437

High

1417027

CDCA4
Cell division cycle-associated protein 4

1

0

High-throughput

0.426

High

1332766

PMGT2
Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2

1

1

High-throughput

0.407

High

1211541

SZT2
KICSTOR complex protein SZT2

2

0

High-throughput

0.328

High

1366095

K0232
Uncharacterized protein KIAA0232

2

0

High-throughput

0.328

High

1398195

CE034
Uncharacterized protein C5orf34

2

0

High-throughput

0.328

High

1435650

NOL11
Nucleolar protein 11

2

0

High-throughput

0.328

High

1435651

GPN2
GPN-loop GTPase 2

2

0

High-throughput

0.328

High

1309076

FABD
Malonyl-CoA-acyl carrier protein transacylase, mitochondrial

2

0

High-throughput

0.298

High

1416234

RPAP1
RNA polymerase II-associated protein 1

1

0

High-throughput

0.279

Low

903796

SSRD
Translocon-associated protein subunit delta

1

0

High-throughput

0.249

Low

980329

H4
Histone H4

1

0

High-throughput

0.249

Low

1435652

SYIM
Isoleucine--tRNA ligase, mitochondrial

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025