Protein: DOCK1
Dedicator of cytokinesis protein 1 (180 kDa protein downstream of CRK) (DOCK180)

Gene: DOCK1
Organism: Homo sapiens
Interactions: 66
UniProt ID: Q14185

Gene Ontology (top 5):
GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0005096 - GTPase activator activity
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1122808

ELMO1
Engulfment and cell motility protein 1

15

20

Small-scale

0.983

High

855620

CRK
Adapter molecule crk

13

20

Small-scale

0.980

High

987631

GRB2
Growth factor receptor-bound protein 2

9

20

Small-scale

0.970

High

988363

RAC1
Ras-related C3 botulinum toxin substrate 1

6

20

Small-scale

0.935

High

1122819

DOCK5
Dedicator of cytokinesis protein 5

3

13

High-throughput

0.852

High

1122798

ANR54
Ankyrin repeat domain-containing protein 54

3

9

High-throughput

0.839

High

581043

RAC2
Ras-related C3 botulinum toxin substrate 2

2

20

High-throughput

0.811

High

855871

CRKL
Crk-like protein

2

20

High-throughput

0.811

High

1122811

ELMO3
Engulfment and cell motility protein 3

2

20

High-throughput

0.811

High

1015434

RHOG
Rho-related GTP-binding protein RhoG

2

20

Small-scale

0.789

High

557299

SRC
Proto-oncogene tyrosine-protein kinase Src

2

13

Small-scale

0.754

High

1122795

DOCK1
Dedicator of cytokinesis protein 1

2

12

Small-scale

0.754

High

222082

NCK2
Cytoplasmic protein NCK2

1

20

Small-scale

0.740

High

1122816

DOCK9
Dedicator of cytokinesis protein 9

2

13

High-throughput

0.737

High

942606

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

13

Small-scale

0.724

High

1122814

CYH2
Cytohesin-2

1

0

Small-scale

0.687

High

1122804

GRASP
Protein TAMALIN

2

7

Small-scale

0.634

High

1122824

FBW1A
F-box/WD repeat-containing protein 1A

3

6

High-throughput

0.633

High

177216

ANR28
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A

1

7

Small-scale

0.618

High

375515

RASK
GTPase KRas

1

20

High-throughput

0.618

High

411915

NTRK1
High affinity nerve growth factor receptor

1

6

High-throughput

0.618

High

440555

FYN
Tyrosine-protein kinase Fyn

1

13

High-throughput

0.618

High

586983

CHIN
N-chimaerin

1

9

High-throughput

0.618

High

593995

NCK1
SH2/SH3 adapter protein NCK1

1

20

High-throughput

0.618

High

978004

RHOB
Rho-related GTP-binding protein RhoB

1

20

High-throughput

0.618

High

1050993

FAK1
Focal adhesion kinase 1

1

20

Small-scale

0.618

High

1122807

ICEF1
Interactor protein for cytohesin exchange factors 1

1

11

Small-scale

0.618

High

1122813

ELMO2
Engulfment and cell motility protein 2

1

20

High-throughput

0.618

High

1122820

ANFY1
Rabankyrin-5

1

7

High-throughput

0.618

High

388194

GLPA
Glycophorin-A

2

2

High-throughput

0.601

High

459588

PROF1
Profilin-1

2

7

Small-scale

0.584

High

1122822

FBW1B
F-box/WD repeat-containing protein 11

2

5

High-throughput

0.584

High

184438

SURF4
Surfeit locus protein 4

2

1

High-throughput

0.571

High

244252

NUAK1
NUAK family SNF1-like kinase 1

1

9

High-throughput

0.536

High

291792

STK16
Serine/threonine-protein kinase 16

1

14

High-throughput

0.536

High

760441

SDC2
Syndecan-2

1

2

High-throughput

0.536

High

1051662

NMDZ1
Glutamate receptor ionotropic, NMDA 1

1

3

High-throughput

0.536

High

1112480

CUL1
Cullin-1

1

10

High-throughput

0.536

High

1122799

L2GL2
LLGL scribble cell polarity complex component 2

1

3

High-throughput

0.536

High

1122810

SPSB4
SPRY domain-containing SOCS box protein 4

1

19

High-throughput

0.536

High

1122815

INP5K
Inositol polyphosphate 5-phosphatase K

1

2

High-throughput

0.536

High

1122818

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

5

High-throughput

0.536

High

605675

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

1

9

Small-scale

0.501

High

1110969

SNW1
SNW domain-containing protein 1

1

1

High-throughput

0.489

High

1122823

VSIG4
V-set and immunoglobulin domain-containing protein 4

1

11

High-throughput

0.489

High

642864

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

3

High-throughput

0.479

High

827295

ARL4A
ADP-ribosylation factor-like protein 4A

1

14

Small-scale

0.479

High

939323

EIF3B
Eukaryotic translation initiation factor 3 subunit B

1

3

High-throughput

0.479

High

1086760

BPTF
Nucleosome-remodeling factor subunit BPTF

1

10

High-throughput

0.479

High

1106532

SMAD4
Mothers against decapentaplegic homolog 4

1

6

High-throughput

0.479

High

1122796

EEA1
Early endosome antigen 1

1

11

High-throughput

0.479

High

1122797

CEBPE
CCAAT/enhancer-binding protein epsilon

1

3

Small-scale

0.479

High

1122801

TRI67
Tripartite motif-containing protein 67

1

18

High-throughput

0.479

High

1122809

ESR2
Estrogen receptor beta

1

7

High-throughput

0.479

High

1122812

SPDLY
Protein Spindly

1

8

High-throughput

0.479

High

1122821

ZRAN1
Ubiquitin thioesterase ZRANB1

1

4

High-throughput

0.479

High

171452

S27A2
Long-chain fatty acid transport protein 2

1

1

High-throughput

0.445

High

262230

SCN2B
Sodium channel regulatory subunit beta-2

1

9

High-throughput

0.445

High

1048354

ACVR1
Activin receptor type-1

1

2

High-throughput

0.445

High

1122817

CD244
Natural killer cell receptor 2B4

1

6

High-throughput

0.445

High

1122800

LRC31
Leucine-rich repeat-containing protein 31

1

5

High-throughput

0.437

High

1122805

VSIG1
V-set and immunoglobulin domain-containing protein 1

1

14

High-throughput

0.407

High

1122806

PMGT2
Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2

1

1

High-throughput

0.407

High

1122802

MEPCE
7SK snRNA methylphosphate capping enzyme

1

0

High-throughput

0.249

Low

1122803

ATG9A
Autophagy-related protein 9A

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025