HitPredict

Interactor 1: Q8IMX8 (Q8IMX8)
U6 snRNA-associated Sm-like protein LSm3
Gene: LSm3

Interactor 2: Q9W087 (Q9W087)
U6 snRNA-associated Sm-like protein LSm8
Gene: l(3)neo7

Species: Drosophila melanogaster

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.82	1.00	0.908

Property	Details
Experiments	37061542, 22036573, unassigned1513, unassigned2874, 38944040
Identification Methods	two hybrid, affinity chromatography technology, two hybrid prey pooling approach, two hybrid array, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	LSM~LSM
Common GO terms	GO:0000398 - mRNA splicing, via spliceosome GO:0003723 - RNA binding GO:0005688 - U6 snRNP GO:0046540 - U4/U6 x U5 tri-snRNP complex GO:0071011 - precatalytic spliceosome
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 103 Dm			1 95
+	Hs
		344526 LSM3_HUMAN (1-103): 4.33e-38: 125: 76.70		LSM8_HUMAN (2-95): 1.26e-33: 113: 69.15
+	Mm
		974304 LSM3_MOUSE (1-103): 4.33e-38: 125: 76.70		LSM8_MOUSE (2-95): 1.26e-33: 113: 69.15
+	Dm
		1303486 Q8IMX8_DROME (1-103): 1.86e-39: 128: 100.00		Q9W2K2_DROME (2-90): 4.89e-25: 92.6: 28.09
+	Hs
		178011 LSM3_HUMAN (1-103): 4.33e-38: 125: 76.70		LSM1_HUMAN (2-90): 3.42e-25: 93: 26.97
+	Mm
		974306 LSM3_MOUSE (1-103): 4.33e-38: 125: 76.70		LSM1_MOUSE (2-90): 3.53e-25: 93: 26.97
+	Hs
		574203 LSM3_HUMAN (1-103): 4.33e-38: 125: 76.70		RSMB_HUMAN (2-75): 1.3e-23: 91.4: 31.33
+	Hs
		344531 RSMN_HUMAN (24-103): 3.92e-27: 101: 21.43		LSM8_HUMAN (2-95): 1.26e-33: 113: 69.15
+	Hs
		344509 RSMB_HUMAN (24-103): 1.28e-26: 99.7: 21.43		LSM8_HUMAN (2-95): 1.26e-33: 113: 69.15
+	Hs
		974292 LSM3_HUMAN (1-103): 4.33e-38: 125: 76.70		LSM7_HUMAN (4-74): 1.58e-23: 87.6: 29.33
+	Dm
		1303480 Q8IMX8_DROME (1-103): 1.86e-39: 128: 100.00		Q9VJI7_DROME (4-74): 1.82e-20: 80.3: 26.32
+	Sp
		267758 LSM3_SCHPO (10-99): 5.4e-30: 104: 60.00		LSM8_SCHPO (3-95): 3.33e-30: 104: 41.94
+	Hs
		974106 LSM3_HUMAN (1-103): 4.33e-38: 125: 76.70		RUXG_HUMAN (4-74): 1.43e-21: 81.8: 29.58
+	Hs
		177994 RSMB_HUMAN (24-103): 1.28e-26: 99.7: 21.43		LSM1_HUMAN (2-90): 3.42e-25: 93: 26.97
+	Hs
		574210 RSMN_HUMAN (24-103): 3.92e-27: 101: 21.43		RSMB_HUMAN (2-75): 1.3e-23: 91.4: 31.33
+	Hs
		574132 RSMB_HUMAN (24-103): 1.28e-26: 99.7: 21.43		RSMB_HUMAN (2-75): 1.3e-23: 91.4: 31.33
+	Hs
		974112 RSMN_HUMAN (24-103): 3.92e-27: 101: 21.43		RUXG_HUMAN (4-74): 1.43e-21: 81.8: 29.58
+	Hs
		574202 RSMB_HUMAN (24-103): 1.28e-26: 99.7: 21.43		RUXG_HUMAN (4-74): 1.43e-21: 81.8: 29.58
+	Hs
		71570 RSMN_HUMAN (24-103): 3.92e-27: 101: 21.43		RUXGL_HUMAN (4-74): 1.04e-19: 77.2: 29.58
+	Hs
		71558 RSMB_HUMAN (24-103): 1.28e-26: 99.7: 21.43		RUXGL_HUMAN (4-74): 1.04e-19: 77.2: 29.58