Protein: LSM1
U6 snRNA-associated Sm-like protein LSm1 (Cancer-associated Sm-like) (Small nuclear ribonuclear CaSm)

Gene: LSM1
Organism: Homo sapiens
Interactions: 92
UniProt ID: O15116

Gene Ontology (top 5):
GO:0000290 - deadenylation-dependent decapping of nuclear-transcribed mRNA
GO:0000375 - RNA splicing, via transesterification reactions
GO:0000932 - P-body
GO:0003723 - RNA binding
GO:0003729 - mRNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

178011

LSM3
U6 snRNA-associated Sm-like protein LSm3

8

20

High-throughput

0.973

High

178060

LSM4
U6 snRNA-associated Sm-like protein LSm4

7

20

Small-scale

0.957

High

178058

LSM2
U6 snRNA-associated Sm-like protein LSm2

5

20

High-throughput

0.925

High

178012

LSM6
U6 snRNA-associated Sm-like protein LSm6

5

20

High-throughput

0.925

High

178034

PATL1
Protein PAT1 homolog 1

5

10

Small-scale

0.923

High

178009

RUXF
Small nuclear ribonucleoprotein F

4

20

High-throughput

0.903

High

178059

LSM5
U6 snRNA-associated Sm-like protein LSm5

2

20

High-throughput

0.811

High

178008

RUXE
Small nuclear ribonucleoprotein E

2

15

High-throughput

0.789

High

178057

LSM7
U6 snRNA-associated Sm-like protein LSm7

2

19

High-throughput

0.789

High

178021

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

2

15

High-throughput

0.754

High

178000

PSB8
Proteasome subunit beta type-8

3

2

High-throughput

0.661

High

178001

PSB5
Proteasome subunit beta type-5

3

2

High-throughput

0.661

High

131088

CLIC1
Chloride intracellular channel protein 1

4

0

Small-scale

0.661

High

178037

LS14A
Protein LSM14 homolog A

3

3

Small-scale

0.656

High

167040

GEMI2
Gem-associated protein 2

1

6

High-throughput

0.618

High

177990

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

18

High-throughput

0.618

High

177994

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

1

15

High-throughput

0.618

High

178003

ICLN
Methylosome subunit pICln

1

8

High-throughput

0.618

High

178010

RUXG
Small nuclear ribonucleoprotein G

1

19

High-throughput

0.618

High

178013

SMD1
Small nuclear ribonucleoprotein Sm D1

1

20

High-throughput

0.618

High

178014

SMD2
Small nuclear ribonucleoprotein Sm D2

1

20

High-throughput

0.618

High

178028

ZMYM1
Zinc finger MYM-type protein 1

2

0

High-throughput

0.585

High

49485

DAPL1
Death-associated protein-like 1

2

0

High-throughput

0.580

High

177977

GSTA4
Glutathione S-transferase A4

2

0

High-throughput

0.580

High

178026

BEX5
Protein BEX5

2

0

High-throughput

0.580

High

91660

PATL2
Protein PAT1 homolog 2

1

9

Small-scale

0.575

High

177999

DDX6
Probable ATP-dependent RNA helicase DDX6

2

9

Small-scale

0.571

High

177984

TCL1B
T-cell leukemia/lymphoma protein 1B

2

2

High-throughput

0.553

High

177985

AGR2
Anterior gradient protein 2 homolog

2

2

High-throughput

0.553

High

178038

AGR3
Anterior gradient protein 3

2

2

High-throughput

0.553

High

177992

CLCA
Clathrin light chain A

1

3

High-throughput

0.536

High

177993

CLCB
Clathrin light chain B

1

3

High-throughput

0.536

High

177998

ROA2
Heterogeneous nuclear ribonucleoproteins A2/B1

1

7

High-throughput

0.536

High

178002

BCL6
B-cell lymphoma 6 protein

1

0

Small-scale

0.513

High

178007

RAB14
Ras-related protein Rab-14

1

0

High-throughput

0.513

High

178019

SMC1A
Structural maintenance of chromosomes protein 1A

1

0

High-throughput

0.513

High

178051

IL36B
Interleukin-36 beta

1

0

High-throughput

0.513

High

178052

PI4KB
Phosphatidylinositol 4-kinase beta

1

0

High-throughput

0.513

High

177978

SYNC
Asparagine--tRNA ligase, cytoplasmic

1

4

High-throughput

0.508

High

177988

HS90A
Heat shock protein HSP 90-alpha

1

3

High-throughput

0.508

High

178020

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

1

High-throughput

0.508

High

178041

EXOS8
Exosome complex component RRP43

1

6

High-throughput

0.508

High

178054

GRHPR
Glyoxylate reductase/hydroxypyruvate reductase

1

1

High-throughput

0.508

High

178029

SPOUT
28S rRNA

1

0

High-throughput

0.493

High

126913

APBB1
Amyloid beta precursor protein binding family B member 1

1

0

High-throughput

0.493

High

177997

COMT
Catechol O-methyltransferase

1

0

High-throughput

0.493

High

178030

TM214
Transmembrane protein 214

1

0

High-throughput

0.486

High

178047

RENT2
Regulator of nonsense transcripts 2

1

0

High-throughput

0.486

High

178053

UXT
Protein UXT

1

0

High-throughput

0.486

High

177986

DHE3
Glutamate dehydrogenase 1, mitochondrial

1

1

High-throughput

0.481

High

178027

EXOS6
Exosome complex component MTR3

1

11

High-throughput

0.481

High

172263

XPO1
Exportin-1

1

4

High-throughput

0.479

High

177976

TIF1A
Transcription intermediary factor 1-alpha

1

7

Small-scale

0.479

High

177979

DNJA2
DnaJ homolog subfamily A member 2

1

3

High-throughput

0.479

High

177982

PRP6
Pre-mRNA-processing factor 6

1

20

High-throughput

0.479

High

177983

TOP3B
DNA topoisomerase 3-beta-1

1

1

High-throughput

0.479

High

177989

RU2B
U2 small nuclear ribonucleoprotein B''

1

17

High-throughput

0.479

High

177991

SNRPA
U1 small nuclear ribonucleoprotein A

1

20

High-throughput

0.479

High

177995

EZRI
Ezrin

1

6

High-throughput

0.479

High

177996

HXK1
Hexokinase-1

1

1

High-throughput

0.479

High

178004

FOXA1
Hepatocyte nuclear factor 3-alpha

1

1

High-throughput

0.479

High

178005

GEMI4
Gem-associated protein 4

1

4

High-throughput

0.479

High

178016

LSM11
U7 snRNA-associated Sm-like protein LSm11

1

4

High-throughput

0.479

High

178023

SMN
Survival motor neuron protein

1

9

High-throughput

0.479

High

178024

PAN2
PAN2-PAN3 deadenylation complex catalytic subunit PAN2

1

1

High-throughput

0.479

High

178025

UBP39
Ubiquitin carboxyl-terminal hydrolase 39

1

5

High-throughput

0.479

High

178032

MEX3B
RNA-binding protein MEX3B

1

1

High-throughput

0.479

High

178033

TRI67
Tripartite motif-containing protein 67

1

3

High-throughput

0.479

High

178036

RHG18
Rho GTPase-activating protein 18

1

2

High-throughput

0.479

High

178039

GEMI6
Gem-associated protein 6

1

5

High-throughput

0.479

High

178040

LRC59
Leucine-rich repeat-containing protein 59

1

1

High-throughput

0.479

High

178043

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

5

High-throughput

0.479

High

178045

DDX23
Probable ATP-dependent RNA helicase DDX23

1

12

High-throughput

0.479

High

178048

4ET
Eukaryotic translation initiation factor 4E transporter

1

1

High-throughput

0.479

High

178049

GEMI8
Gem-associated protein 8

1

5

High-throughput

0.479

High

178055

DDX20
Probable ATP-dependent RNA helicase DDX20

1

16

High-throughput

0.479

High

178056

BAZ2B
Bromodomain adjacent to zinc finger domain protein 2B

1

2

High-throughput

0.479

High

178046

VPS11
Vacuolar protein sorting-associated protein 11 homolog

1

4

High-throughput

0.464

High

177980

N4BP1
NEDD4-binding protein 1

1

0

High-throughput

0.460

High

178018

TFCP2
Alpha-globin transcription factor CP2

1

0

High-throughput

0.460

High

178015

ACTC
Actin, alpha cardiac muscle 1

1

0

High-throughput

0.458

High

178022

ZFHX3
Zinc finger homeobox protein 3

1

0

High-throughput

0.458

High

178044

RNZ2
Zinc phosphodiesterase ELAC protein 2

1

0

High-throughput

0.458

High

178050

F120C
Constitutive coactivator of PPAR-gamma-like protein 2

1

0

High-throughput

0.458

High

3668

NBDY
Negative regulator of P-body association

1

1

Small-scale

0.445

High

178017

TAGL
Transgelin

1

1

High-throughput

0.445

High

178031

EDC4
Enhancer of mRNA-decapping protein 4

1

4

Small-scale

0.445

High

178035

XRN1
5'-3' exoribonuclease 1

1

3

Small-scale

0.445

High

178042

F136A
Protein FAM136A

1

0

High-throughput

0.438

High

178006

MCCD1
Mitochondrial coiled-coil domain protein 1

2

0

High-throughput

0.316

High

177987

FIBB
Fibrinogen beta chain [Cleaved into: Fibrinopeptide B; Fibrinogen beta chain]

1

0

High-throughput

0.279

Low

177981

MPU1
Mannose-P-dolichol utilization defect 1 protein

1

0

High-throughput

0.251

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025