HitPredict

Interactor 1: NFIP1 (Q9BT67)
NEDD4 family-interacting protein 1 (Breast cancer-associated protein SGA-1M) (NEDD4 WW domain-binding protein 5) (Putative MAPK-activating protein PM13) (Putative NF-kappa-B-activating protein 164) (Putative NFKB and MAPK-activating protein)
Gene: NDFIP1

Interactor 2: SMUF1 (Q9HCE7)
E3 ubiquitin-protein ligase SMURF1 (hSMURF1) (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase SMURF1) (SMAD ubiquitination regulatory factor 1) (SMAD-specific E3 ubiquitin-protein ligase 1)
Gene: SMURF1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	23087404
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0006511 - ubiquitin-dependent protein catabolic process
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 221 Hs			1 757
+	Mm
		1208047 NFIP1_MOUSE (1-221): 1.54e-136: 383: 97.29		ITCH_MOUSE (1-757): 0: 763: 33.03
+	Hs
		1294848 NFIP1_HUMAN (1-221): 1.9e-136: 383: 100.00		ITCH_HUMAN (1-757): 0: 733: 31.28
+	Hs
		125686 NFIP1_HUMAN (1-221): 1.9e-136: 383: 100.00		WWP2_HUMAN (97-757): 0: 708: 36.69
+	Mm
		808368 NFIP1_MOUSE (1-221): 1.54e-136: 383: 97.29		NEDD4_MOUSE (2-755): 0: 684: 31.80
+	Rn
		1137274 NFIP1_RAT (1-221): 2.44e-135: 380: 97.74		NEDD4_RAT (5-755): 0: 678: 32.15
+	Hs
		808249 NFIP1_HUMAN (1-221): 1.9e-136: 383: 100.00		NEDD4_HUMAN (93-755): 0: 673: 36.63
+	Hs
		1294871 NFIP2_HUMAN (12-220): 5.72e-98: 290: 55.46		ITCH_HUMAN (1-757): 0: 733: 31.28
+	Mm
		93279 NFIP1_MOUSE (1-221): 1.54e-136: 383: 97.29		E9PXB7_MOUSE (153-755): 0: 633: 40.69
+	Hs
		125746 NFIP2_HUMAN (12-220): 5.72e-98: 290: 55.46		WWP2_HUMAN (97-757): 0: 708: 36.69
+	Hs
		808291 NFIP2_HUMAN (12-220): 5.72e-98: 290: 55.46		NEDD4_HUMAN (93-755): 0: 673: 36.63
+	Hs
		1299617 NFIP1_HUMAN (1-221): 1.9e-136: 383: 100.00		NED4L_HUMAN (6-396): 7.88e-36: 147: 16.88
+	Hs
		1311857 NFIP1_HUMAN (1-221): 1.9e-136: 383: 100.00		WWP1_HUMAN (2-395): 1.65e-27: 121: 14.94
+	Hs
		1299647 NFIP2_HUMAN (12-220): 5.72e-98: 290: 55.46		NED4L_HUMAN (6-396): 7.88e-36: 147: 16.88
+	Hs
		1327920 NFIP2_HUMAN (12-220): 5.72e-98: 290: 55.46		WWP1_HUMAN (2-395): 1.65e-27: 121: 14.94
+	Dm
		1374786 Q9VVJ5_DROME (100-221): 4.9e-53: 173: 40.98		NEDD4_DROME (2-302): 1.49e-34: 143: 17.92
+	Dm
		1360300 Q9VVJ5_DROME (100-221): 4.9e-53: 173: 40.98		SMUF1_DROME (5-293): 2.09e-29: 127: 34.24
+	Dm
		1374794 Q9VVJ5_DROME (100-221): 4.9e-53: 173: 40.98		SUDX_DROME (14-413): 1.29e-24: 112: 15.47