Protein: PHRF1
PHD and RING finger domain-containing protein 1

Gene: PHRF1
Organism: Homo sapiens
Interactions: 68
UniProt ID: Q9P1Y6

Gene Ontology (top 5):
GO:0008270 - zinc ion binding
GO:0016020 - membrane
GO:0016567 - protein ubiquitination
GO:0070063 - RNA polymerase binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1239683

JMJD6
Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6

3

5

Small-scale

0.770

High

625676

CSK22
Casein kinase II subunit alpha'

5

17

High-throughput

0.650

High

982346

UB2D2
Ubiquitin-conjugating enzyme E2 D2

1

9

High-throughput

0.647

High

995316

CSK2B
Casein kinase II subunit beta

4

3

High-throughput

0.625

High

1099585

SRSF6
Serine/arginine-rich splicing factor 6

1

20

High-throughput

0.618

High

1033279

EWS
RNA-binding protein EWS

1

19

High-throughput

0.618

High

1162063

H31T
Histone H3.1t

1

20

Small-scale

0.609

High

667490

RPB1
DNA-directed RNA polymerase II subunit RPB1

2

3

Small-scale

0.584

High

397108

ESR1
Estrogen receptor

2

20

High-throughput

0.571

High

912254

RPB11
DNA-directed RNA polymerase II subunit RPB11-a

2

4

High-throughput

0.558

High

998076

CSK21
Casein kinase II subunit alpha

2

18

High-throughput

0.558

High

1437383

LN28A
Protein lin-28 homolog A

2

11

High-throughput

0.552

High

788246

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

5

High-throughput

0.536

High

1447095

RPR1B
Regulation of nuclear pre-mRNA domain-containing protein 1B

2

13

High-throughput

0.521

High

1288810

KTN1
Kinectin

1

20

High-throughput

0.515

High

1145411

RNPS1
RNA-binding protein with serine-rich domain 1

1

11

High-throughput

0.514

High

134894

SAP18
Histone deacetylase complex subunit SAP18

1

4

High-throughput

0.489

High

1370421

CSN5
COP9 signalosome complex subunit 5

1

6

High-throughput

0.489

High

558456

XRCC6
X-ray repair cross-complementing protein 6

1

16

Small-scale

0.479

High

559527

XRCC5
X-ray repair cross-complementing protein 5

1

16

Small-scale

0.479

High

723127

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

2

High-throughput

0.479

High

787807

RPB9
DNA-directed RNA polymerase II subunit RPB9

1

1

High-throughput

0.479

High

980460

H4
Histone H4

1

17

High-throughput

0.479

High

983726

RPAB5
DNA-directed RNA polymerases I, II, and III subunit RPABC5

1

1

High-throughput

0.479

High

1114504

CUL3
Cullin-3

1

13

High-throughput

0.479

High

1135143

CUL7
Cullin-7

1

6

High-throughput

0.479

High

1313068

RPAP2
Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2

1

1

High-throughput

0.479

High

1367460

ESR2
Estrogen receptor beta

1

20

High-throughput

0.479

High

1399400

NLRP3
NACHT, LRR and PYD domains-containing protein 3

1

1

High-throughput

0.479

High

1454177

ZRAN1
Ubiquitin thioesterase ZRANB1

1

13

High-throughput

0.479

High

1454179

PRP19
Pre-mRNA-processing factor 19

1

20

High-throughput

0.479

High

596394

H12
Histone H1.2

1

18

High-throughput

0.470

High

968012

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

16

Small-scale

0.457

High

686492

RL13
Large ribosomal subunit protein eL13

1

5

High-throughput

0.445

High

178582

PLCB
1-acyl-sn-glycerol-3-phosphate acyltransferase beta

1

1

High-throughput

0.439

High

192877

RPB4
DNA-directed RNA polymerase II subunit RPB4

1

1

High-throughput

0.437

High

262141

NBN
Nibrin

1

2

Small-scale

0.437

High

262575

MCE1
mRNA-capping enzyme

1

6

High-throughput

0.437

High

349269

LATS1
Serine/threonine-protein kinase LATS1

1

8

High-throughput

0.437

High

591386

CD44
CD44 antigen

1

2

High-throughput

0.437

High

621779

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

3

High-throughput

0.437

High

621999

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

1

2

High-throughput

0.437

High

659310

SP100
Nuclear autoantigen Sp-100

1

20

High-throughput

0.437

High

912146

RPAB3
DNA-directed RNA polymerases I, II, and III subunit RPABC3

1

1

High-throughput

0.437

High

976170

RPB7
DNA-directed RNA polymerase II subunit RPB7

1

1

High-throughput

0.437

High

1015325

ERH
Enhancer of rudimentary homolog

1

3

High-throughput

0.437

High

1045855

TF65
Transcription factor p65

1

14

High-throughput

0.437

High

1128132

DHX8
ATP-dependent RNA helicase DHX8

1

15

High-throughput

0.437

High

1217630

RPRD2
Regulation of nuclear pre-mRNA domain-containing protein 2

1

19

High-throughput

0.437

High

1232036

GL1AD
DNA-directed RNA polymerase II subunit GRINL1A, isoforms 4/5

1

1

High-throughput

0.437

High

1270348

SPT6H
Transcription elongation factor SPT6

1

8

High-throughput

0.437

High

1278700

KI21A
Kinesin-like protein KIF21A

1

3

High-throughput

0.437

High

1339009

NUP43
Nucleoporin Nup43

1

20

High-throughput

0.437

High

1346966

SNIP1
Smad nuclear-interacting protein 1

1

6

High-throughput

0.437

High

1387609

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

20

High-throughput

0.437

High

1399371

RPR1A
Regulation of nuclear pre-mRNA domain-containing protein 1A

1

9

High-throughput

0.437

High

1414605

DDX23
Probable ATP-dependent RNA helicase DDX23

1

18

High-throughput

0.437

High

1435882

SFR19
Splicing factor, arginine/serine-rich 19

1

19

High-throughput

0.437

High

1439337

GPN1
GPN-loop GTPase 1

1

1

High-throughput

0.437

High

1448218

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

11

High-throughput

0.437

High

1452246

AATF
Protein AATF

1

3

High-throughput

0.437

High

1452567

BCLF1
Bcl-2-associated transcription factor 1

1

19

High-throughput

0.437

High

1454178

ACINU
Apoptotic chromatin condensation inducer in the nucleus

1

18

High-throughput

0.437

High

1454180

TR150
Thyroid hormone receptor-associated protein 3

1

20

High-throughput

0.437

High

290771

SURF6
Surfeit locus protein 6

1

2

High-throughput

0.407

High

786900

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

16

High-throughput

0.407

High

1006767

SRPK2
SRSF protein kinase 2

1

19

High-throughput

0.407

High

1199727

KLH22
Kelch-like protein 22

1

4

High-throughput

0.407

High


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Last updated: 11Aug2025