HitPredict

Interactor 1: HACE1 (Q8IYU2)
E3 ubiquitin-protein ligase HACE1 (EC 2.3.2.26) (HECT domain and ankyrin repeat-containing E3 ubiquitin-protein ligase 1) (HECT-type E3 ubiquitin transferase HACE1)
Gene: HACE1

Interactor 2: HACE1 (Q8IYU2)
E3 ubiquitin-protein ligase HACE1 (EC 2.3.2.26) (HECT domain and ankyrin repeat-containing E3 ubiquitin-protein ligase 1) (HECT-type E3 ubiquitin transferase HACE1)
Gene: HACE1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.77 1.00 0.882

The method score is based on:

Property Details
Experiments 26949039, 29362425, 37537642
Identification Methods enzymatic study, affinity chromatography technology, x-ray crystallography, pull down
Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains Ank_2~Ank_2, Ank_2~Ank_4, Ank_2~HECT, Ank_4~Ank_4, HECT~HECT
Common GO terms GO:0000139 - Golgi membrane
GO:0004842 - ubiquitin-protein transferase activity
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005783 - endoplasmic reticulum
and 11 others

more...
Homologous interactions 14

Homologous interactions

Color coding for hit scores

1 909
Hs

1 909
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Service provided by Combinatics, Japan

Last updated: 11Aug2025