HitPredict

Interactor 1: SHAN3 (Q9BYB0)
SH3 and multiple ankyrin repeat domains protein 3 (Shank3) (Proline-rich synapse-associated protein 2) (ProSAP2)
Gene: SHANK3

Interactor 2: LTBP3 (Q9NS15)
Latent-transforming growth factor beta-binding protein 3 (LTBP-3)
Gene: LTBP3

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	0.50	0.494

Property	Details
Experiments	21653829
Identification Methods	two hybrid, two hybrid pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1731 Hs			1 1303
+	Hs
		980523 SHAN3_HUMAN (1-1731): 0: 596: 100.00		NOTC2_HUMAN (900-1294): 1.5e-25: 117: 16.67
+	Hs
		254237 SHAN3_HUMAN (1-1731): 0: 596: 100.00		MEGF6_HUMAN (3-569): 7.32e-25: 115: 12.34
+	Hs
		1231801 SHAN3_HUMAN (1-1731): 0: 596: 100.00		LTBP4_HUMAN (16-909): 3.03e-24: 113: 14.83
+	Hs
		1316311 SHAN3_HUMAN (1-1731): 0: 596: 100.00		NOTC3_HUMAN (39-581): 6.69e-24: 112: 9.32
+	Hs
		804330 SHAN3_HUMAN (1-1731): 0: 596: 100.00		NOTC1_HUMAN (14-442): 6.92e-15: 82.4: 8.05
+	Hs
		328048 SHAN3_HUMAN (1-1731): 0: 596: 100.00		FBLN4_HUMAN (801-1126): 4.58e-12: 72: 26.59
+	Hs
		1016988 SHAN3_HUMAN (1-1731): 0: 596: 100.00		FBLN3_HUMAN (842-1128): 1.6e-11: 70.5: 26.37
+	Hs
		1316313 SHAN3_HUMAN (1-1731): 0: 596: 100.00		JAG2_HUMAN (1059-1300): 3.16e-09: 63.9: 11.98
+	Hs
		166914 ANR28_HUMAN (27-335): 3.42e-77: 281: 16.48		NOTC2_HUMAN (900-1294): 1.5e-25: 117: 16.67
+	Hs
		167042 ANR28_HUMAN (27-335): 3.42e-77: 281: 16.48		NOTC3_HUMAN (39-581): 6.69e-24: 112: 9.32
+	Hs
		957287 TNKS2_HUMAN (220-558): 1.49e-36: 153: 12.29		FBLN2_HUMAN (775-1284): 2.25e-10: 67.4: 25.24
+	Hs
		980449 ANR44_HUMAN (2-151): 2.27e-20: 100: 14.01		NOTC2_HUMAN (900-1294): 1.5e-25: 117: 16.67
+	Hs
		1237561 ANR44_HUMAN (2-151): 2.27e-20: 100: 14.01		NOTC3_HUMAN (39-581): 6.69e-24: 112: 9.32
+	Dm
		65546 A8JNM5_DROME (649-1691): 7.65e-24: 112: 11.17		NOTCH_DROME (998-1303): 2.26e-16: 87.4: 13.64
+	Hs
		804293 ANR44_HUMAN (2-151): 2.27e-20: 100: 14.01		NOTC1_HUMAN (14-442): 6.92e-15: 82.4: 8.05
+	Hs
		944122 MIB1_HUMAN (129-324): 9.56e-15: 82: 32.50		JAG1_HUMAN (77-459): 3.02e-17: 90.1: 10.29
+	Mm
		1193398 MIB1_MOUSE (129-324): 1.56e-14: 81.6: 32.50		JAG1_MOUSE (77-459): 1.03e-16: 88.2: 9.80
+	Dm
		422915 MIB_DROME (134-324): 1.09e-12: 75.5: 32.31		NOTCH_DROME (998-1303): 2.26e-16: 87.4: 13.64
+	Mm
		1193399 MIB1_MOUSE (129-324): 1.56e-14: 81.6: 32.50		JAG2_MOUSE (7-364): 3.54e-12: 73.6: 12.22
+	Dm
		113976 M9PB30_DROME (349-1110): 2.53e-09: 65.1: 11.73		M9PB30_DROME (16-659): 1.9e-10: 68.2: 10.59