Protein: SCYL2
SCY1-like protein 2 (Coated vesicle-associated kinase of 104 kDa)

Gene: SCYL2
Organism: Homo sapiens
Interactions: 180
UniProt ID: Q6P3W7

Gene Ontology (top 5):
GO:0004672 - protein kinase activity
GO:0005102 - signaling receptor binding
GO:0005524 - ATP binding
GO:0005794 - Golgi apparatus
GO:0007420 - brain development

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

976346

RB11A
Ras-related protein Rab-11A

2

4

High-throughput

0.754

High

443412

CDK1
Cyclin-dependent kinase 1

1

1

High-throughput

0.691

High

1107838

SQSTM
Sequestosome-1

2

4

High-throughput

0.675

High

995649

ACTC
Actin, alpha cardiac muscle 1

1

3

High-throughput

0.665

High

943258

RBM11
Splicing regulator RBM11

1

2

High-throughput

0.625

High

1160171

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

1

5

High-throughput

0.618

High

1242010

THOC4
THO complex subunit 4

1

1

High-throughput

0.618

High

242027

PRKN
E3 ubiquitin-protein ligase parkin

1

11

High-throughput

0.618

High

272266

OBSL1
Obscurin-like protein 1

1

2

High-throughput

0.618

High

363432

EGFR
Epidermal growth factor receptor

1

11

High-throughput

0.618

High

412106

NTRK1
High affinity nerve growth factor receptor

1

20

High-throughput

0.618

High

541552

FGFR1
Fibroblast growth factor receptor 1

1

20

High-throughput

0.618

High

573529

ENPL
Endoplasmin

1

13

High-throughput

0.618

High

630548

RAB3B
Ras-related protein Rab-3B

1

3

High-throughput

0.618

High

631296

RAB5A
Ras-related protein Rab-5A

1

4

High-throughput

0.618

High

641196

FGFR2
Fibroblast growth factor receptor 2

1

20

High-throughput

0.618

High

648559

FGFR4
Fibroblast growth factor receptor 4

1

20

High-throughput

0.618

High

945022

RAB25
Ras-related protein Rab-25

1

4

High-throughput

0.618

High

978093

RHOB
Rho-related GTP-binding protein RhoB

1

10

High-throughput

0.618

High

1025472

CDK5
Cyclin-dependent kinase 5

1

1

High-throughput

0.618

High

1144965

RAB35
Ras-related protein Rab-35

1

3

High-throughput

0.618

High

1242061

ST38L
Serine/threonine-protein kinase 38-like

1

8

High-throughput

0.618

High

483126

CLCA
Clathrin light chain A

2

2

High-throughput

0.611

High

396341

ESR1
Estrogen receptor

2

9

High-throughput

0.594

High

1242035

BAG1
BAG family molecular chaperone regulator 1

1

0

High-throughput

0.578

High

650234

FGFR3
Fibroblast growth factor receptor 3

1

20

High-throughput

0.575

High

159365

DVL1
Segment polarity protein dishevelled homolog DVL-1

1

9

Small-scale

0.561

High

138175

PSDE
26S proteasome non-ATPase regulatory subunit 14

2

3

High-throughput

0.558

High

341086

DIRA3
GTP-binding protein Di-Ras3

1

4

High-throughput

0.553

High

350047

SNAI1
Zinc finger protein SNAI1

1

1

High-throughput

0.553

High

601337

RHOQ
Rho-related GTP-binding protein RhoQ

1

13

High-throughput

0.553

High

630847

RAB4A
Ras-related protein Rab-4A

1

5

High-throughput

0.553

High

901883

RAB9A
Ras-related protein Rab-9A

1

5

High-throughput

0.553

High

962170

RHOA
Transforming protein RhoA

1

9

High-throughput

0.553

High

1015531

RHOG
Rho-related GTP-binding protein RhoG

1

8

High-throughput

0.553

High

1137075

SART3
Spliceosome associated factor 3, U4/U6 recycling protein

1

3

High-throughput

0.553

High

1242004

TRI67
Tripartite motif-containing protein 67

1

8

High-throughput

0.553

High

1242012

MIB1
E3 ubiquitin-protein ligase MIB1

1

2

High-throughput

0.553

High

1242014

MIRO2
Mitochondrial Rho GTPase 2

1

14

High-throughput

0.553

High

1242044

RHOJ
Rho-related GTP-binding protein RhoJ

1

13

High-throughput

0.553

High

1242045

PKHA4
Pleckstrin homology domain-containing family A member 4

1

7

High-throughput

0.553

High

1242055

PD1L1
Programmed cell death 1 ligand 1

1

5

Small-scale

0.553

High

1242059

UBQL2
Ubiquilin-2

1

5

High-throughput

0.553

High

1242062

NINL
Ninein-like protein

1

7

High-throughput

0.553

High

537363

HSP7C
Heat shock cognate 71 kDa protein

1

8

High-throughput

0.536

High

732629

ARRB2
Beta-arrestin-2

1

1

High-throughput

0.536

High

872446

SOX2
Transcription factor SOX-2

1

7

High-throughput

0.536

High

930943

HSP72
Heat shock-related 70 kDa protein 2

1

8

High-throughput

0.536

High

932477

KAD2
Adenylate kinase 2, mitochondrial

1

1

High-throughput

0.536

High

1129822

EPN4
Clathrin interactor 1

1

2

High-throughput

0.536

High

1242037

AKAP9
A-kinase anchor protein 9

1

3

High-throughput

0.536

High

414041

P53
Cellular tumor antigen p53

2

6

Small-scale

0.533

High

855652

CRK
Adapter molecule crk

2

1

High-throughput

0.521

High

1242036

SH3G3
Endophilin-A3

2

7

High-throughput

0.521

High

1242039

OVOL2
Transcription factor Ovo-like 2

1

0

Small-scale

0.517

High

640922

VDAC1
Non-selective voltage-gated ion channel VDAC1

1

0

High-throughput

0.513

High

1026089

CLH1
Clathrin heavy chain 1

1

0

High-throughput

0.513

High

1106317

FZD5
Frizzled-5

1

3

Small-scale

0.512

High

390621

TFR1
Transferrin receptor protein 1

1

0

High-throughput

0.493

High

175084

SC16A
Protein transport protein Sec16A

1

3

High-throughput

0.489

High

347112

BAG2
BAG family molecular chaperone regulator 2

1

2

High-throughput

0.489

High

652335

TGM1
Protein-glutamine gamma-glutamyltransferase K

1

1

High-throughput

0.489

High

882516

ARRB1
Beta-arrestin-1

1

1

High-throughput

0.489

High

1025713

PURA
Transcriptional activator protein Pur-alpha

1

2

High-throughput

0.489

High

1111052

SNW1
SNW domain-containing protein 1

1

1

High-throughput

0.489

High

1242029

TGM7
Protein-glutamine gamma-glutamyltransferase Z

1

1

High-throughput

0.489

High

1242034

CDC5L
Cell division cycle 5-like protein

1

9

High-throughput

0.489

High

1242043

NSRP1
Nuclear speckle splicing regulatory protein 1

1

2

High-throughput

0.489

High

1242054

GTSE1
G2 and S phase-expressed protein 1

1

2

High-throughput

0.489

High

218334

TGON2
Trans-Golgi network integral membrane protein 2

1

5

High-throughput

0.479

High

226082

STX6
Syntaxin-6

1

3

High-throughput

0.479

High

257054

F262
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2

1

1

High-throughput

0.479

High

293865

CD123
Translation initiation factor eIF2 assembly protein

1

1

High-throughput

0.479

High

327318

ZFPL1
Zinc finger protein-like 1

1

2

High-throughput

0.479

High

483354

CLCB
Clathrin light chain B

1

2

High-throughput

0.479

High

604040

CXA1
Gap junction alpha-1 protein

1

4

High-throughput

0.479

High

807468

IF4A3
Eukaryotic initiation factor 4A-III

1

2

High-throughput

0.479

High

970667

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

3

High-throughput

0.479

High

989013

AP2B1
AP-2 complex subunit beta

1

8

High-throughput

0.479

High

1113422

CUL3
Cullin-3

1

2

High-throughput

0.479

High

1242007

ATG9A
Autophagy-related protein 9A

1

1

High-throughput

0.479

High

1242013

CUL9
Cullin-9

1

4

High-throughput

0.479

High

1242018

LZTR1
Leucine-zipper-like transcriptional regulator 1

1

6

Small-scale

0.479

High

1242020

GBF1
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

1

2

High-throughput

0.479

High

1242038

GORS1
Golgi reassembly-stacking protein 1

1

3

High-throughput

0.479

High

1242042

WWTR1
WW domain-containing transcription regulator protein 1

1

4

High-throughput

0.479

High

1242046

GORS2
Golgi reassembly-stacking protein 2

1

3

High-throughput

0.479

High

336117

ZFYV9
Zinc finger FYVE domain-containing protein 9

1

4

High-throughput

0.464

High

278875

PEX14
Peroxisomal membrane protein PEX14

1

0

High-throughput

0.458

High

731401

STIP1
Stress-induced-phosphoprotein 1

1

0

High-throughput

0.458

High

1242053

OCAD1
OCIA domain-containing protein 1

1

0

High-throughput

0.458

High

1242058

CHRD1
Cysteine and histidine-rich domain-containing protein 1

1

0

High-throughput

0.458

High

1242032

CK5P2
CDK5 regulatory subunit-associated protein 2

1

7

High-throughput

0.445

High

123256

PDLI1
PDZ and LIM domain protein 1

1

10

High-throughput

0.437

High

129187

MEN1
Menin

1

1

High-throughput

0.437

High

139901

RCAS1
Receptor-binding cancer antigen expressed on SiSo cells

1

2

High-throughput

0.437

High

140962

NOP56
Nucleolar protein 56

1

2

Small-scale

0.437

High

172958

XPO1
Exportin-1

1

7

High-throughput

0.437

High

176497

GRRE1
Granule associated Rac and RHOG effector protein 1

1

1

High-throughput

0.437

High

179938

BET1
BET1 homolog

1

3

High-throughput

0.437

High

187987

EIF3H
Eukaryotic translation initiation factor 3 subunit H

1

3

Small-scale

0.437

High

189641

STX7
Syntaxin-7

1

2

High-throughput

0.437

High

260094

BRD4
Bromodomain-containing protein 4

1

1

High-throughput

0.437

High

291392

NU155
Nuclear pore complex protein Nup155

1

1

High-throughput

0.437

High

323434

TRI37
E3 ubiquitin-protein ligase TRIM37

1

11

High-throughput

0.437

High

474758

VIME
Vimentin

1

2

High-throughput

0.437

High

556160

CADH1
Cadherin-1

1

3

High-throughput

0.437

High

562148

LAMP2
Lysosome-associated membrane glycoprotein 2

1

1

High-throughput

0.437

High

576239

PO2F1
POU domain, class 2, transcription factor 1

1

3

Small-scale

0.437

High

588949

RFA2
Replication protein A 32 kDa subunit

1

4

High-throughput

0.437

High

642935

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

1

High-throughput

0.437

High

695736

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

6

High-throughput

0.437

High

715633

MARCS
Myristoylated alanine-rich C-kinase substrate

1

3

High-throughput

0.437

High

768454

RFA3
Replication protein A 14 kDa subunit

1

5

High-throughput

0.437

High

833296

PERI
Peripherin

1

2

High-throughput

0.437

High

878486

PAXI
Paxillin

1

2

High-throughput

0.437

High

896557

VASP
Vasodilator-stimulated phosphoprotein

1

6

High-throughput

0.437

High

951719

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

3

Small-scale

0.437

High

964020

COPZ1
Coatomer subunit zeta-1

1

2

High-throughput

0.437

High

986501

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

2

High-throughput

0.437

High

1138321

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

2

High-throughput

0.437

High

1156379

SEPT7
Septin-7

1

2

High-throughput

0.437

High

1157650

CRY1
Cryptochrome-1

1

1

High-throughput

0.437

High

1196993

AMOT
Angiomotin

1

8

High-throughput

0.437

High

1213490

UBAP2
Ubiquitin-associated protein 2

1

1

High-throughput

0.437

High

1233284

LTOR1
Ragulator complex protein LAMTOR1

1

1

High-throughput

0.437

High

1242003

SYNE3
Nesprin-3

1

5

High-throughput

0.437

High

1242008

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

5

High-throughput

0.437

High

1242011

TMM17
Transmembrane protein 17

1

2

High-throughput

0.437

High

1242015

CNTRB
Centrobin

1

7

High-throughput

0.437

High

1242016

RHG18
Rho GTPase-activating protein 18

1

1

High-throughput

0.437

High

1242019

SMAP2
Stromal membrane-associated protein 2

1

2

High-throughput

0.437

High

1242021

AKAP1
A-kinase anchor protein 1, mitochondrial

1

1

High-throughput

0.437

High

1242022

ESR2
Estrogen receptor beta

1

9

High-throughput

0.437

High

1242024

REQU
Zinc finger protein ubi-d4

1

1

High-throughput

0.437

High

1242026

CHM4C
Charged multivesicular body protein 4c

1

1

High-throughput

0.437

High

1242028

DDRGK
DDRGK domain-containing protein 1

1

1

High-throughput

0.437

High

1242040

TRIM6
Tripartite motif-containing protein 6

1

3

Small-scale

0.437

High

1242041

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

4

High-throughput

0.437

High

1242050

SEP11
Septin-11

1

2

High-throughput

0.437

High

1242051

KBTB4
Kelch repeat and BTB domain-containing protein 4

1

5

High-throughput

0.437

High

1242056

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

1

5

High-throughput

0.437

High

1242057

ZRAN1
Ubiquitin thioesterase ZRANB1

1

7

High-throughput

0.437

High

1242060

LAMP3
Lysosome-associated membrane glycoprotein 3

1

1

High-throughput

0.437

High

1242064

SHLB1
Endophilin-B1

1

7

High-throughput

0.437

High

1242065

RPGF2
Rap guanine nucleotide exchange factor 2

1

1

High-throughput

0.437

High

1242031

VPS35
Vacuolar protein sorting-associated protein 35

1

0

Small-scale

0.426

High

529969

TAU
Microtubule-associated protein tau

1

5

High-throughput

0.407

High

1242030

SYGP1
Ras/Rap GTPase-activating protein SynGAP

1

5

High-throughput

0.407

High

1226887

A16L1
Autophagy-related protein 16-1

2

0

High-throughput

0.298

High

709130

TPP2
Tripeptidyl-peptidase 2

1

0

High-throughput

0.279

Low

773904

SOAT1
Sterol O-acyltransferase 1

1

0

High-throughput

0.279

Low

1092568

ECH1
Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial

1

0

High-throughput

0.279

Low

1219185

SPAT1
Spermatogenesis-associated protein 1

1

0

High-throughput

0.279

Low

1242006

COX15
Heme A synthase COX15

1

0

High-throughput

0.279

Low

1242017

RYBP
RING1 and YY1-binding protein

1

0

High-throughput

0.279

Low

1242027

COQ2
4-hydroxybenzoate polyprenyltransferase, mitochondrial

1

0

High-throughput

0.279

Low

1242048

DPOE3
DNA polymerase epsilon subunit 3

1

0

High-throughput

0.279

Low

257472

PAGE4
P antigen family member 4

1

0

High-throughput

0.249

Low

319846

UFL1
E3 UFM1-protein ligase 1

1

0

High-throughput

0.249

Low

378121

TNFA
Tumor necrosis factor

1

0

High-throughput

0.249

Low

437224

K2C8
Keratin, type II cytoskeletal 8

1

0

High-throughput

0.249

Low

459639

PROF1
Profilin-1

1

0

High-throughput

0.249

Low

925937

TCP4
Activated RNA polymerase II transcriptional coactivator p15

1

0

High-throughput

0.249

Low

961049

MGN
Protein mago nashi homolog

1

0

High-throughput

0.249

Low

1013148

SARNP
SAP domain-containing ribonucleoprotein

1

0

High-throughput

0.249

Low

1147617

TOM20
Mitochondrial import receptor subunit TOM20 homolog

1

0

High-throughput

0.249

Low

1205435

EMC4
ER membrane protein complex subunit 4

1

0

High-throughput

0.249

Low

1226448

DCA15
DDB1- and CUL4-associated factor 15

1

0

High-throughput

0.249

Low

1229530

VIR
Protein virilizer homolog

1

0

High-throughput

0.249

Low

1242005

MOB2
MOB kinase activator 2

1

0

High-throughput

0.249

Low

1242009

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.249

Low

1242023

PRCC
Proline-rich protein PRCC

1

0

High-throughput

0.249

Low

1242025

CK052
Uncharacterized protein C11orf52

1

0

High-throughput

0.249

Low

1242033

RMD3
Regulator of microtubule dynamics protein 3

1

0

High-throughput

0.249

Low

1242047

FBX6
F-box only protein 6

1

0

High-throughput

0.249

Low

1242049

TOM22
Mitochondrial import receptor subunit TOM22 homolog

1

0

High-throughput

0.249

Low

1242052

FBX34
F-box only protein 34

1

0

Small-scale

0.249

Low

1242063

RRP44
Exosome complex exonuclease RRP44

1

0

High-throughput

0.249

Low

87491

OSCRI
SCRIB overlapping open reading frame protein

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025