HitPredict

Interactor 1: SIR6 (Q8N6T7)
NAD-dependent protein deacylase sirtuin-6 (EC 2.3.1.-) (NAD-dependent protein deacetylase sirtuin-6) (EC 2.3.1.286) (Protein mono-ADP-ribosyltransferase sirtuin-6) (EC 2.4.2.-) (Regulatory protein SIR2 homolog 6) (hSIRT6) (SIR2-like protein 6)
Gene: SIRT6

Interactor 2: H2A1H (Q96KK5)
Histone H2A type 1-H (H2A-clustered histone 12) (Histone H2A/s)
Gene: H2AC12

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	34244565
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Histone~SIR2, Histone_H2A_C~SIR2
Common GO terms	GO:0003677 - DNA binding GO:0005634 - nucleus
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 355 Hs			1 128
+	Hs
		502436 SIR6_HUMAN (1-355): 2.26e-166: 469: 100.00		H2A1_HUMAN (1-128): 1.31e-66: 199: 100.00
+	Hs
		419084 SIR6_HUMAN (1-355): 2.26e-166: 469: 100.00		H2A1B_HUMAN (1-128): 1.86e-66: 198: 98.44
+	Hs
		1307276 SIR6_HUMAN (1-355): 2.26e-166: 469: 100.00		H2A2B_HUMAN (1-128): 1.07e-65: 196: 95.31
+	Hs
		1162834 SIR6_HUMAN (1-355): 2.26e-166: 469: 100.00		H2A2C_HUMAN (1-125): 1.35e-64: 194: 97.60
+	Hs
		1307295 SIR1_HUMAN (25-336): 3.37e-99: 311: 21.83		H2A2B_HUMAN (1-128): 1.07e-65: 196: 95.31
+	Hs
		419071 SIR2_HUMAN (31-318): 3.22e-102: 308: 22.12		H2A1B_HUMAN (1-128): 1.86e-66: 198: 98.44
+	Hs
		1162903 SIR7_HUMAN (22-321): 2.14e-101: 306: 38.61		H2A2C_HUMAN (1-125): 1.35e-64: 194: 97.60
+	Hs
		591853 SIR7_HUMAN (22-321): 2.14e-101: 306: 38.61		H2AX_HUMAN (1-123): 3.76e-63: 190: 95.12
+	Sc
		419318 SIR2_YEAST (33-288): 1.6e-86: 273: 20.00		H2A1_YEAST (16-127): 3.4e-53: 165: 81.25
+	Sc
		419543 SIR2_YEAST (33-288): 1.6e-86: 273: 20.00		H2A2_YEAST (16-127): 3.4e-53: 165: 81.25