HitPredict

Interactor 1: GLIS3 (Q8NEA6)
Zinc finger protein GLIS3 (GLI-similar 3) (Zinc finger protein 515)
Gene: GLIS3

Interactor 2: SUFU (Q9UMX1)
Suppressor of fused homolog (SUFUH)
Gene: SUFU

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.78	0.60	0.686

Property	Details
Experiments	26147758, 16189514, 21543335, 20211142
Identification Methods	affinity chromatography technology, two hybrid, two hybrid array, two hybrid pooling approach
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 775 Hs			1 484
+	Mm
		1223140 GLI3_MOUSE (104-647): 2.35e-110: 370: 31.30		SUFU_MOUSE (1-484): 0: 914: 97.73
+	Hs
		517562 GLI3_HUMAN (105-647): 5.71e-111: 371: 31.66		SUFU_HUMAN (1-484): 0: 912: 100.00
+	Mm
		1081841 GLI2_MOUSE (94-618): 1.27e-109: 367: 35.62		SUFU_MOUSE (1-484): 0: 914: 97.73
+	Hs
		517505 GLI2_HUMAN (94-619): 4.38e-109: 366: 36.20		SUFU_HUMAN (1-484): 0: 912: 100.00
+	Mm
		867727 GLI1_MOUSE (137-574): 1.73e-88: 304: 36.65		SUFU_MOUSE (1-484): 0: 914: 97.73
+	Hs
		466715 GLI1_HUMAN (115-602): 5.63e-86: 296: 35.37		SUFU_HUMAN (1-484): 0: 912: 100.00
+	Dr
		1281789 Q9YGS4_DANRE (94-588): 8.14e-98: 333: 33.08		Q7ZVZ9_DANRE (16-484): 0: 846: 80.95
+	Hs
		1156069 ZIC1_HUMAN (347-496): 3.52e-40: 155: 49.38		SUFU_HUMAN (1-484): 0: 912: 100.00
+	Dr
		1281788 Q800Z9_DANRE (347-549): 1.93e-51: 196: 55.71		Q7ZVZ9_DANRE (16-484): 0: 846: 80.95
+	Dm
		624392 CI_DROME (347-506): 4.22e-53: 201: 63.98		Q9VG38_DROME (31-484): 0: 662: 37.71
+	Dm
		624310 CI_DROME (347-506): 4.22e-53: 201: 63.98		Q27279_DROME (31-484): 0: 656: 37.50