Protein: SUFU
Suppressor of fused homolog (SUFUH)

Gene: SUFU
Organism: Homo sapiens
Interactions: 95
UniProt ID: Q9UMX1

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0001843 - neural tube closure
GO:0001947 - heart looping
GO:0003281 - ventricular septum development
GO:0003714 - transcription corepressor activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

466715

GLI1
Zinc finger protein GLI1

17

11

Small-scale

0.766

High

1392755

ZN764
Zinc finger protein 764

7

2

High-throughput

0.747

High

1415066

ZN747
Zinc finger protein 747

6

2

High-throughput

0.739

High

719388

MPIP3
M-phase inducer phosphatase 3

5

2

High-throughput

0.718

High

517562

GLI3
Transcriptional activator GLI3

4

11

Small-scale

0.697

High

517505

GLI2
Zinc finger protein GLI2

4

11

Small-scale

0.696

High

1337272

GLIS3
Zinc finger protein GLIS3

4

11

Small-scale

0.686

High

1451379

ZN446
Zinc finger protein 446

3

3

High-throughput

0.667

High

1348734

ZSC18
Zinc finger and SCAN domain-containing protein 18

3

3

High-throughput

0.665

High

69843

ZN785
Zinc finger protein 785

3

1

High-throughput

0.662

High

1108866

BFSP2
Phakinin

5

1

High-throughput

0.653

High

1462112

SUFU
Suppressor of fused homolog

1

1

Small-scale

0.647

High

1459086

FXL17
F-box/LRR-repeat protein 17

3

0

Small-scale

0.645

High

1276008

HDX
Highly divergent homeobox

3

0

High-throughput

0.639

High

722764

AL1B1
Aldehyde dehydrogenase X, mitochondrial

3

0

High-throughput

0.638

High

1462113

LIPT
Lipoyl amidotransferase LIPT1, mitochondrial

3

0

High-throughput

0.638

High

1462116

NR2E1
Nuclear receptor subfamily 2 group E member 1

3

0

High-throughput

0.638

High

1462118

TTLL3
Tubulin monoglycylase TTLL3

3

0

High-throughput

0.638

High

1446142

M1IP1
Mid1-interacting protein 1

3

0

High-throughput

0.638

High

1091759

NFAC3
Nuclear factor of activated T-cells, cytoplasmic 3

3

0

High-throughput

0.634

High

945949

LOXL3
Lysyl oxidase homolog 3

2

1

High-throughput

0.611

High

1156069

ZIC1
Zinc finger protein ZIC 1

2

11

High-throughput

0.606

High

1198358

CRTC2
CREB-regulated transcription coactivator 2

2

1

High-throughput

0.606

High

1277655

K1C27
Keratin, type I cytoskeletal 27

2

1

High-throughput

0.606

High

1395262

LMBL3
Lethal(3)malignant brain tumor-like protein 3

2

2

High-throughput

0.606

High

1454442

ABI3
ABI gene family member 3

2

1

High-throughput

0.606

High

244791

ZC3H1
Zinc finger C3H1 domain-containing protein

2

0

High-throughput

0.602

High

554269

BMP4
Bone morphogenetic protein 4

2

0

High-throughput

0.602

High

1280112

UBE3D
E3 ubiquitin-protein ligase E3D

2

0

High-throughput

0.602

High

1359956

PRP31
U4/U6 small nuclear ribonucleoprotein Prp31

2

0

High-throughput

0.602

High

163518

ZN213
Zinc finger protein 213

2

1

High-throughput

0.601

High

162994

OVOL1
Putative transcription factor Ovo-like 1

2

0

High-throughput

0.595

High

1289781

ZBT46
Zinc finger and BTB domain-containing protein 46

2

0

High-throughput

0.585

High

171941

ZN263
Zinc finger protein 263

2

0

High-throughput

0.582

High

210147

CRX
Cone-rod homeobox protein

2

0

High-throughput

0.580

High

341878

K2C75
Keratin, type II cytoskeletal 75

2

0

High-throughput

0.580

High

900223

FXR1
RNA-binding protein FXR1

2

0

High-throughput

0.580

High

1061922

TLE5
TLE family member 5

2

0

High-throughput

0.580

High

1068873

ZN763
Zinc finger protein 763

2

0

High-throughput

0.580

High

1291378

LCA5
Lebercilin

2

0

High-throughput

0.580

High

1334462

ZN114
Zinc finger protein 114

2

0

High-throughput

0.580

High

1448556

DISC1
Disrupted in schizophrenia 1 protein

2

0

High-throughput

0.580

High

1462114

LZTS1
Leucine zipper putative tumor suppressor 1

2

0

High-throughput

0.580

High

1462115

ZN330
Zinc finger protein 330

2

0

High-throughput

0.580

High

1394639

ITCH
E3 ubiquitin-protein ligase Itchy homolog

1

1

Small-scale

0.578

High

1411687

RHG09
Rho GTPase-activating protein 9

2

1

High-throughput

0.571

High

1462117

TRAF6
TNF receptor-associated factor 6

1

1

Small-scale

0.561

High

1277829

PEX26
Peroxisome assembly protein 26

1

0

High-throughput

0.558

High

1311226

RHG12
Rho GTPase-activating protein 12

1

1

High-throughput

0.536

High

578566

BRAF
Serine/threonine-protein kinase B-raf

1

0

High-throughput

0.525

High

1144807

NADC
Nicotinate-nucleotide pyrophosphorylase [carboxylating]

1

0

High-throughput

0.518

High

1232640

Q6FHY5
MEOX2 protein

1

1

High-throughput

0.515

High

1289902

Q86V38
Atrophin 1

1

1

High-throughput

0.515

High

377842

IGF2
Insulin-like growth factor 2

1

0

High-throughput

0.513

High

651137

CCNO
Cyclin-O

1

0

High-throughput

0.513

High

833794

KDM5C
Lysine-specific demethylase 5C

1

0

High-throughput

0.513

High

1435451

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.513

High

274842

PX11A
Peroxisomal membrane protein 11A

1

0

High-throughput

0.493

High

1369715

KLK6
Kallikrein-6

1

0

High-throughput

0.493

High

1460543

MAGL2
MAGE-like protein 2

1

0

High-throughput

0.493

High

1454238

NYAP2
Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2

1

1

High-throughput

0.489

High

894247

MEOX2
Homeobox protein MOX-2

1

1

High-throughput

0.481

High

134910

SAP18
Histone deacetylase complex subunit SAP18

1

1

Small-scale

0.479

High

891355

GSK3A
Glycogen synthase kinase-3 alpha

1

1

High-throughput

0.479

High

891881

GSK3B
Glycogen synthase kinase-3 beta

1

1

High-throughput

0.479

High

1253753

RHG36
Rho GTPase-activating protein 36

1

1

Small-scale

0.479

High

1350500

BICD2
Protein bicaudal D homolog 2

1

1

High-throughput

0.479

High

1391214

BICD1
Protein bicaudal D homolog 1

1

1

High-throughput

0.479

High

1448755

STK36
Serine/threonine-protein kinase 36

1

2

Small-scale

0.479

High

1280050

SH3R1
E3 ubiquitin-protein ligase SH3RF1

1

0

High-throughput

0.460

High

688340

TTP
mRNA decay activator protein ZFP36

1

0

High-throughput

0.458

High

905706

IRAK1
Interleukin-1 receptor-associated kinase 1

1

0

Small-scale

0.458

High

951903

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

0

Small-scale

0.458

High

1114648

CUL3
Cullin-3

1

0

High-throughput

0.458

High

1117077

RUNX3
Runt-related transcription factor 3

1

0

Small-scale

0.458

High

1252417

MEX3B
RNA-binding protein MEX3B

1

0

High-throughput

0.458

High

1407260

M3K3
Mitogen-activated protein kinase kinase kinase 3

1

0

Small-scale

0.458

High

1407683

MYD88
Myeloid differentiation primary response protein MyD88

1

0

Small-scale

0.458

High

1460580

HOOK1
Protein Hook homolog 1

1

0

High-throughput

0.458

High

85919

B9A025
Lysyl oxidase homolog

1

1

High-throughput

0.407

High

1295130

F90A1
Protein FAM90A1

4

0

High-throughput

0.365

High

327093

NXPH3
Neurexophilin-3

4

0

High-throughput

0.360

High

1386989

RCN3
Reticulocalbin-3

3

0

High-throughput

0.353

High

181028

LRAD4
Low-density lipoprotein receptor class A domain-containing protein 4

3

0

High-throughput

0.347

High

1163717

PCKGM
Phosphoenolpyruvate carboxykinase [GTP], mitochondrial

2

0

High-throughput

0.328

High

1169514

LRC36
Leucine-rich repeat-containing protein 36

2

0

High-throughput

0.328

High

1365534

EDEM1
ER degradation-enhancing alpha-mannosidase-like protein 1

2

0

High-throughput

0.328

High

1326413

STX19
Syntaxin-19

2

0

High-throughput

0.316

High

1392597

S41A3
Solute carrier family 41 member 3

2

0

High-throughput

0.316

High

1242434

ACKMT
ATP synthase subunit C lysine N-methyltransferase

1

0

High-throughput

0.279

Low

1249664

CF015
Uncharacterized protein C6orf15

1

0

High-throughput

0.279

Low

1390139

MYEOV
Myeloma-overexpressed gene protein

1

0

High-throughput

0.279

Low

143947

NDKM
Nucleoside diphosphate kinase, mitochondrial

1

0

High-throughput

0.268

Low

1147709

TOM20
Mitochondrial import receptor subunit TOM20 homolog

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025