Protein: GLI1
Zinc finger protein GLI1 (Glioma-associated oncogene) (Oncogene GLI)

Gene: GLI1
Organism: Homo sapiens
Interactions: 120
UniProt ID: P08151

Gene Ontology (top 5):
GO:0000976 - transcription cis-regulatory region binding
GO:0000977 - RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

466635

KPCI
Protein kinase C iota type

2

3

Small-scale

0.812

High

466620

CDK4
Cyclin-dependent kinase 4

2

7

Small-scale

0.799

High

466715

SUFU
Suppressor of fused homolog

17

11

Small-scale

0.766

High

466659

AAPK1
5'-AMP-activated protein kinase catalytic subunit alpha-1

2

2

Small-scale

0.754

High

167795

IKKB
Inhibitor of nuclear factor kappa-B kinase subunit beta

1

4

Small-scale

0.747

High

466646

AAPK2
5'-AMP-activated protein kinase catalytic subunit alpha-2

1

2

High-throughput

0.740

High

466671

ZIC1
Zinc finger protein ZIC 1

1

18

Small-scale

0.724

High

466702

M3K3
Mitogen-activated protein kinase kinase kinase 3

1

2

Small-scale

0.724

High

466718

M3K2
Mitogen-activated protein kinase kinase kinase 2

1

1

Small-scale

0.724

High

466628

KS6B1
Ribosomal protein S6 kinase beta-1

1

5

Small-scale

0.715

High

466706

STK36
Serine/threonine-protein kinase 36

1

5

Small-scale

0.665

High

466625

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

1

4

Small-scale

0.647

High

466697

ITCH
E3 ubiquitin-protein ligase Itchy homolog

2

4

Small-scale

0.641

High

466663

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

3

0

Small-scale

0.641

High

466692

KAT2B
Histone acetyltransferase KAT2B

3

9

Small-scale

0.640

High

466717

FBW1A
F-box/WD repeat-containing protein 1A

3

10

Small-scale

0.640

High

466680

UBP48
Ubiquitin carboxyl-terminal hydrolase 48

2

12

Small-scale

0.624

High

177770

IKKA
Inhibitor of nuclear factor kappa-B kinase subunit alpha

1

5

Small-scale

0.618

High

336212

ZIC2
Zinc finger protein ZIC 2

1

18

Small-scale

0.618

High

443129

CDK1
Cyclin-dependent kinase 1

1

2

Small-scale

0.618

High

466619

GLI3
Transcriptional activator GLI3

1

18

Small-scale

0.618

High

466676

MARK2
Serine/threonine-protein kinase MARK2

1

1

Small-scale

0.618

High

466698

ZN521
Zinc finger protein 521

1

7

Small-scale

0.618

High

466700

SRPK1
SRSF protein kinase 1

1

6

Small-scale

0.618

High

466664

HDAC1
Histone deacetylase 1

2

12

Small-scale

0.584

High

466631

AQP1
Aquaporin-1

2

0

High-throughput

0.580

High

466685

CTSR1
Cation channel sperm-associated protein 1

2

0

High-throughput

0.580

High

466617

GLI1
Zinc finger protein GLI1

1

17

High-throughput

0.575

High

466682

TRI42
Tripartite motif-containing protein 42

1

20

High-throughput

0.573

High

466695

GCC1
GRIP and coiled-coil domain-containing protein 1

1

7

High-throughput

0.573

High

466640

NUMB
Protein numb homolog

1

1

Small-scale

0.561

High

466655

TCPB
T-complex protein 1 subunit beta

1

2

Small-scale

0.561

High

466672

TAF9
Transcription initiation factor TFIID subunit 9

1

2

Small-scale

0.561

High

466703

ANM1
Protein arginine N-methyltransferase 1

1

6

Small-scale

0.561

High

466704

MEP50
Methylosome protein WDR77

1

4

Small-scale

0.561

High

466712

FEM1B
Protein fem-1 homolog B

1

5

Small-scale

0.561

High

466681

THOC4
THO complex subunit 4

2

0

Small-scale

0.559

High

466678

RAI1
Retinoic acid-induced protein 1

1

2

High-throughput

0.541

High

466666

RUNX3
Runt-related transcription factor 3

1

0

Small-scale

0.537

High

413036

P53
Cellular tumor antigen p53

1

5

High-throughput

0.536

High

466623

TRI27
Zinc finger protein RFP

1

11

High-throughput

0.536

High

466626

DESM
Desmin

1

11

High-throughput

0.536

High

466636

RL21
Large ribosomal subunit protein eL21

1

1

High-throughput

0.536

High

466642

FXR1
RNA-binding protein FXR1

1

5

High-throughput

0.536

High

466644

SMCA4
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4

1

8

High-throughput

0.536

High

466667

ZMYM3
Zinc finger MYM-type protein 3

1

5

High-throughput

0.536

High

466673

KIF7
Kinesin-like protein KIF7

1

5

High-throughput

0.536

High

466675

CRACD
Capping protein-inhibiting regulator of actin dynamics

1

5

High-throughput

0.536

High

466687

SMRC2
SWI/SNF complex subunit SMARCC2

1

4

High-throughput

0.536

High

466688

SNX33
Sorting nexin-33

1

1

High-throughput

0.536

High

466689

IFT81
Intraflagellar transport protein 81 homolog

1

6

High-throughput

0.536

High

466693

RAD50
DNA repair protein RAD50

1

10

High-throughput

0.536

High

466699

IFT74
Intraflagellar transport protein 74 homolog

1

5

High-throughput

0.536

High

466633

VHL
von Hippel-Lindau disease tumor suppressor

1

1

Small-scale

0.534

High

466627

XBP1
X-box-binding protein 1

1

0

High-throughput

0.518

High

48131

IFT56
Intraflagellar transport protein 56

1

0

High-throughput

0.513

High

466641

MRE11
Double-strand break repair protein MRE11

1

0

High-throughput

0.513

High

466707

SYFB
Phenylalanine--tRNA ligase beta subunit

1

0

High-throughput

0.513

High

162439

ANM5
Protein arginine N-methyltransferase 5

1

5

Small-scale

0.501

High

207417

DHX15
ATP-dependent RNA helicase DHX15

1

2

Small-scale

0.479

High

222421

PLRG1
Pleiotropic regulator 1

1

6

Small-scale

0.479

High

224212

BUB3
Mitotic checkpoint protein BUB3

1

3

Small-scale

0.479

High

334663

IPO7
Importin-7

1

20

Small-scale

0.479

High

437059

K2C8
Keratin, type II cytoskeletal 8

1

4

Small-scale

0.479

High

446561

NPM
Nucleophosmin

1

8

Small-scale

0.479

High

461044

HS90A
Heat shock protein HSP 90-alpha

1

3

Small-scale

0.479

High

466618

HS90B
Heat shock protein HSP 90-beta

1

3

Small-scale

0.479

High

466629

PTBP1
Polypyrimidine tract-binding protein 1

1

5

Small-scale

0.479

High

466634

STAT3
Signal transducer and activator of transcription 3

1

3

Small-scale

0.479

High

466637

YAP1
Transcriptional coactivator YAP1

1

9

Small-scale

0.479

High

466643

FXR2
RNA-binding protein FXR2

1

5

Small-scale

0.479

High

466647

HSP72
Heat shock-related 70 kDa protein 2

1

3

Small-scale

0.479

High

466648

ACTB
Actin, cytoplasmic 1

1

4

Small-scale

0.479

High

466649

PP1B
Serine/threonine-protein phosphatase PP1-beta catalytic subunit

1

8

Small-scale

0.479

High

466651

GBB1
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

1

2

Small-scale

0.479

High

466652

GNAI1
Guanine nucleotide-binding protein G(i) subunit alpha-1

1

1

Small-scale

0.479

High

466653

RACK1
Small ribosomal subunit protein RACK1

1

3

Small-scale

0.479

High

466654

TBA1B
Tubulin alpha-1B chain

1

2

Small-scale

0.479

High

466657

ILF3
Interleukin enhancer-binding factor 3

1

7

Small-scale

0.479

High

466658

TRI32
E3 ubiquitin-protein ligase TRIM32

1

13

Small-scale

0.479

High

466660

EIF3I
Eukaryotic translation initiation factor 3 subunit I

1

4

Small-scale

0.479

High

466661

SMAD4
Mothers against decapentaplegic homolog 4

1

9

Small-scale

0.479

High

466662

TBB3
Tubulin beta-3 chain

1

3

Small-scale

0.479

High

466665

ASPP2
Apoptosis-stimulating of p53 protein 2

1

6

Small-scale

0.479

High

466668

GNA13
Guanine nucleotide-binding protein subunit alpha-13

1

1

Small-scale

0.479

High

466669

IMB1
Importin subunit beta-1

1

13

Small-scale

0.479

High

466670

SMAD2
Mothers against decapentaplegic homolog 2

1

9

Small-scale

0.479

High

466674

K2C79
Keratin, type II cytoskeletal 79

1

4

Small-scale

0.479

High

466679

UBP37
Ubiquitin carboxyl-terminal hydrolase 37

1

2

Small-scale

0.479

High

466686

NUP35
Nucleoporin NUP35

1

1

High-throughput

0.479

High

466690

DDX1
ATP-dependent RNA helicase DDX1

1

4

Small-scale

0.479

High

466691

HDAC2
Histone deacetylase 2

1

12

Small-scale

0.479

High

466694

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

12

Small-scale

0.479

High

466701

PHB2
Prohibitin-2

1

1

Small-scale

0.479

High

466705

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.479

High

466709

HDAC6
Protein deacetylase HDAC6

1

13

Small-scale

0.479

High

466711

ZRAN1
Ubiquitin thioesterase ZRANB1

1

5

High-throughput

0.479

High

466713

UBP21
Ubiquitin carboxyl-terminal hydrolase 21

1

1

Small-scale

0.479

High

466714

PRP19
Pre-mRNA-processing factor 19

1

5

Small-scale

0.479

High

134528

SAP18
Histone deacetylase complex subunit SAP18

1

0

Small-scale

0.458

High

136197

IFRD1
Interferon-related developmental regulator 1

1

0

Small-scale

0.458

High

179293

ARPC2
Actin-related protein 2/3 complex subunit 2

1

0

Small-scale

0.458

High

466621

IMDH2
Inosine-5'-monophosphate dehydrogenase 2

1

0

Small-scale

0.458

High

466624

SYDC
Aspartate--tRNA ligase, cytoplasmic

1

0

Small-scale

0.458

High

466630

EF1D
Elongation factor 1-delta

1

0

Small-scale

0.458

High

466638

CAZA2
F-actin-capping protein subunit alpha-2

1

0

Small-scale

0.458

High

466639

CAPZB
F-actin-capping protein subunit beta

1

0

Small-scale

0.458

High

466656

RL6
Large ribosomal subunit protein eL6

1

0

Small-scale

0.458

High

466677

NUFP2
FMR1-interacting protein NUFIP2

1

0

Small-scale

0.458

High

466684

SERB1
SERPINE1 mRNA-binding protein 1

1

0

Small-scale

0.458

High

466708

LMBD1
Lysosomal cobalamin transport escort protein LMBD1

1

0

High-throughput

0.458

High

466710

FXL17
F-box/LRR-repeat protein 17

1

0

Small-scale

0.458

High

466716

ABCG2
Broad substrate specificity ATP-binding cassette transporter ABCG2

1

0

Small-scale

0.458

High

466632

BMI1
Polycomb complex protein BMI-1

1

11

High-throughput

0.445

High

466650

1433E
14-3-3 protein epsilon

1

2

Small-scale

0.445

High

466645

CRBA4
Beta-crystallin A4

1

0

High-throughput

0.299

High

466622

P4HA1
Prolyl 4-hydroxylase subunit alpha-1

1

0

High-throughput

0.279

Low

466683

ALLC
Probable inactive allantoicase

1

0

High-throughput

0.279

Low

466696

PGAM5
Serine/threonine-protein phosphatase PGAM5, mitochondrial

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025