HitPredict

Interactor 1: HIPPO (Q8T0S6)
Serine/threonine-protein kinase hippo (EC 2.7.11.1) (Drosophila homolog of MST1 and MST2) (STE20-like kinase MST) (dMST)
Gene: hpo

Interactor 2: HIPPO (Q8T0S6)
Serine/threonine-protein kinase hippo (EC 2.7.11.1) (Drosophila homolog of MST1 and MST2) (STE20-like kinase MST) (dMST)
Gene: hpo

Species: Drosophila melanogaster

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.94 1.00 0.973

The method score is based on:

Property Details
Experiments 14502294, 22215676, 12941273, 14502295, 23263283, 23298890, 16860746, 32213597
Identification Methods affinity chromatography technology, enzymatic study, fluorescent resonance energy transfer, protein complementation assay, two hybrid, pull down
Interaction Type physical association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains Mst1_SARAH~Mst1_SARAH, Mst1_SARAH~Pkinase, Pkinase~Pkinase
Common GO terms GO:0001654 - eye development
GO:0001745 - compound eye morphogenesis
GO:0002011 - morphogenesis of an epithelial sheet
GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding
and 30 others

more...
Homologous interactions 17

Homologous interactions

Color coding for hit scores

1 669
Dm

1 669
+ Dm
+ Dm
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Rn
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs

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Last updated: 11Aug2025