HitPredict

Interactor 1: VAV3 (Q9UKW4)
Guanine nucleotide exchange factor VAV3 (VAV-3)
Gene: VAV3

Interactor 2: ALK (Q9UM73)
ALK tyrosine kinase receptor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD antigen CD246)
Gene: ALK

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	17998938
Identification Methods	coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	C1_1~PK_Tyr_Ser-Thr, PH~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 847 Hs			1 1620
+	Hs
		1071026 VAV3_HUMAN (1-847): 0: 663: 100.00		ERBB4_HUMAN (882-1547): 2.9e-122: 418: 22.24
+	Hs
		445884 VAV3_HUMAN (1-847): 0: 663: 100.00		ROS1_HUMAN (1039-1461): 3.68e-112: 397: 37.75
+	Hs
		411523 VAV3_HUMAN (1-847): 0: 663: 100.00		INSR_HUMAN (973-1436): 1.01e-112: 392: 34.25
+	Hs
		435801 VAV3_HUMAN (1-847): 0: 663: 100.00		IGF1R_HUMAN (1037-1385): 8.86e-111: 386: 39.77
+	Hs
		548711 VAV_HUMAN (1-846): 0: 609: 57.31		ERBB4_HUMAN (882-1547): 2.9e-122: 418: 22.24
+	Hs
		507829 VAV_HUMAN (1-846): 0: 609: 57.31		FGFR1_HUMAN (952-1454): 2.04e-118: 395: 26.06
+	Hs
		411288 VAV_HUMAN (1-846): 0: 609: 57.31		INSR_HUMAN (973-1436): 1.01e-112: 392: 34.25
+	Hs
		855797 VAV2_HUMAN (1-846): 0: 574: 50.00		ERBB4_HUMAN (882-1547): 2.9e-122: 418: 22.24
+	Hs
		548706 VAV_HUMAN (1-846): 0: 609: 57.31		FAK2_HUMAN (1054-1518): 4.66e-109: 374: 27.45
+	Hs
		384538 VAV2_HUMAN (1-846): 0: 574: 50.00		NTRK1_HUMAN (1111-1392): 5.05e-62: 230: 42.07
+	Hs
		435676 FGD5_HUMAN (1-614): 5.83e-77: 275: 13.26		IGF1R_HUMAN (1037-1385): 8.86e-111: 386: 39.77
+	Hs
		224717 KALRN_HUMAN (152-705): 9.15e-54: 205: 14.14		ERBB4_HUMAN (882-1547): 2.9e-122: 418: 22.24
+	Hs
		562648 PLCG2_HUMAN (661-845): 3.61e-15: 82.4: 32.18		ERBB4_HUMAN (882-1547): 2.9e-122: 418: 22.24
+	Hs
		507835 PLCG2_HUMAN (661-845): 3.61e-15: 82.4: 32.18		FGFR1_HUMAN (952-1454): 2.04e-118: 395: 26.06
+	Hs
		411292 PLCG1_HUMAN (661-845): 1.02e-14: 80.9: 30.35		INSR_HUMAN (973-1436): 1.01e-112: 392: 34.25
+	Hs
		279829 TRIO_HUMAN (181-666): 3.3e-52: 201: 13.29		NTRK1_HUMAN (1111-1392): 5.05e-62: 230: 42.07
+	Hs
		279869 TRIO_HUMAN (181-666): 3.3e-52: 201: 13.29		NTRK3_HUMAN (1093-1375): 2.69e-59: 223: 39.03
+	Hs
		384821 ARHG7_HUMAN (747-847): 4.63e-15: 81.8: 27.72		NTRK1_HUMAN (1111-1392): 5.05e-62: 230: 42.07
+	Hs
		384239 PLCG1_HUMAN (661-845): 1.02e-14: 80.9: 30.35		NTRK1_HUMAN (1111-1392): 5.05e-62: 230: 42.07
+	Hs
		562650 PLCG2_HUMAN (661-845): 3.61e-15: 82.4: 32.18		NTRK3_HUMAN (1093-1375): 2.69e-59: 223: 39.03