HitPredict

Interactor 1: HDAC2 (Q92769)
Histone deacetylase 2 (HD2) (EC 3.5.1.98) (Protein deacylase HDAC2) (EC 3.5.1.-)
Gene: HDAC2

Interactor 2: EHMT2 (Q96KQ7)
Histone-lysine N-methyltransferase EHMT2 (EC 2.1.1.-) (EC 2.1.1.367) (Euchromatic histone-lysine N-methyltransferase 2) (HLA-B-associated transcript 8) (Histone H3-K9 methyltransferase 3) (H3-K9-HMTase 3) (Lysine N-methyltransferase 1C) (Protein G9a)
Gene: EHMT2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.667

Property	Details
Experiments	21258344, 35271311, 26028330
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0000785 - chromatin GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:1990841 - promoter-specific chromatin binding
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 488 Hs			1 1210
+	Hs
		1109993 HDAC1_HUMAN (1-443): 0: 642: 90.07		EHMT2_HUMAN (21-1210): 0: 903: 100.00
+	Hs
		1368129 HDAC2_HUMAN (1-488): 0: 707: 100.00		EHMT1_HUMAN (1-1209): 0: 666: 45.16
+	Hs
		1110089 HDAC1_HUMAN (1-443): 0: 642: 90.07		EHMT1_HUMAN (1-1209): 0: 666: 45.16
+	Dm
		121777 HDAC1_DROME (5-472): 0: 653: 77.92		M9PGH7_DROME (8-1210): 9.22e-153: 501: 23.71
+	Hs
		216501 HDAC2_HUMAN (1-488): 0: 707: 100.00		SUV91_HUMAN (863-1177): 6.62e-88: 292: 31.71
+	Mm
		236515 HDAC2_MOUSE (1-488): 0: 704: 99.39		SUV91_MOUSE (863-1177): 5.71e-84: 281: 30.95
+	Hs
		177211 HDAC1_HUMAN (1-443): 0: 642: 90.07		ANR28_HUMAN (584-1085): 2.49e-84: 299: 17.82
+	Hs
		216430 HDAC1_HUMAN (1-443): 0: 642: 90.07		SUV91_HUMAN (863-1177): 6.62e-88: 292: 31.71
+	Mm
		148627 HDAC1_MOUSE (1-443): 0: 645: 90.29		SUV91_MOUSE (863-1177): 5.71e-84: 281: 30.95
+	Hs
		188111 HDAC3_HUMAN (10-431): 0: 574: 58.26		SUV91_HUMAN (863-1177): 6.62e-88: 292: 31.71
+	Hs
		1311358 HDAC2_HUMAN (1-488): 0: 707: 100.00		ANKH1_HUMAN (709-1047): 1.35e-35: 150: 16.86
+	Mm
		236511 HDAC3_MOUSE (10-431): 0: 574: 58.49		SUV91_MOUSE (863-1177): 5.71e-84: 281: 30.95
+	Hs
		274215 HDAC2_HUMAN (1-488): 0: 707: 100.00		ANR17_HUMAN (708-1007): 4.56e-23: 109: 16.78
+	Dm
		853556 HDAC1_DROME (5-472): 0: 653: 77.92		SUV39_DROME (934-1176): 1.29e-28: 125: 36.84
+	Hs
		274143 HDAC1_HUMAN (1-443): 0: 642: 90.07		ANR17_HUMAN (708-1007): 4.56e-23: 109: 16.78
+	Mm
		1240023 HDAC4_MOUSE (1-377): 6.15e-133: 412: 23.89		TNKS1_MOUSE (621-1010): 1.35e-73: 270: 20.69