HitPredict

Interactor 1: SHAN2 (Q9UPX8)
SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin-binding protein 1) (CortBP1) (Proline-rich synapse-associated protein 1)
Gene: SHANK2

Interactor 2: DLGP4 (Q9Y2H0)
Disks large-associated protein 4 (DAP-4) (PSD-95/SAP90-binding protein 4) (SAP90/PSD-95-associated protein 4) (SAPAP-4)
Gene: DLGAP4

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.621

Property	Details
Experiments	10527873
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	GKAP~PDZ_6
Common GO terms	GO:0005886 - plasma membrane GO:0098978 - glutamatergic synapse
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1849 Hs			1 992
+	Hs
		145956 SHAN2_HUMAN (1-1849): 0: 672: 100.00		DLGP1_HUMAN (1-992): 0: 1167: 46.62
+	Hs
		1349917 SHAN2_HUMAN (1-1849): 0: 672: 100.00		DLGP2_HUMAN (1-992): 0: 1064: 43.22
+	Hs
		1316315 SHAN3_HUMAN (50-1846): 1.84e-117: 413: 39.60		DLGP4_HUMAN (1-992): 0: 1252: 100.00
+	Hs
		327248 SHAN2_HUMAN (1-1849): 0: 672: 100.00		DLGP3_HUMAN (1-992): 0: 986: 35.35
+	Mm
		69915 SHAN3_MOUSE (50-1846): 5.37e-115: 406: 39.87		DLGP4_MOUSE (1-992): 0: 1229: 96.88
+	Hs
		145954 SHAN3_HUMAN (50-1846): 1.84e-117: 413: 39.60		DLGP1_HUMAN (1-992): 0: 1167: 46.62
+	Rn
		956996 SHAN3_RAT (50-1846): 7.69e-117: 411: 39.30		DLGP1_RAT (1-992): 0: 1152: 46.00
+	Mm
		1116115 SHAN3_MOUSE (50-1846): 5.37e-115: 406: 39.87		DLGP1_MOUSE (1-992): 0: 1144: 45.61
+	Rn
		956997 SHAN2_RAT (380-1849): 7.52e-99: 353: 88.41		DLGP1_RAT (1-992): 0: 1152: 46.00
+	Mm
		1194593 SHAN2_MOUSE (380-1849): 5.22e-98: 351: 87.20		DLGP1_MOUSE (1-992): 0: 1144: 45.61
+	Hs
		1316300 SHAN3_HUMAN (50-1846): 1.84e-117: 413: 39.60		DLGP2_HUMAN (1-992): 0: 1064: 43.22
+	Mm
		1116003 SHAN3_MOUSE (50-1846): 5.37e-115: 406: 39.87		DLGP2_MOUSE (1-992): 0: 1070: 41.73
+	Hs
		327247 SHAN3_HUMAN (50-1846): 1.84e-117: 413: 39.60		DLGP3_HUMAN (1-992): 0: 986: 35.35
+	Rn
		102520 SHAN3_RAT (50-1846): 7.69e-117: 411: 39.30		G3V7T8_RAT (1-992): 0: 970: 35.85
+	Mm
		1115961 SHAN3_MOUSE (50-1846): 5.37e-115: 406: 39.87		DLGP3_MOUSE (1-992): 0: 970: 35.75
+	Hs
		145958 SHAN1_HUMAN (521-1849): 1.53e-26: 121: 13.57		DLGP1_HUMAN (1-992): 0: 1167: 46.62
+	Rn
		956998 SHAN1_RAT (444-1849): 8.98e-28: 125: 13.34		DLGP1_RAT (1-992): 0: 1152: 46.00
+	Mm
		88376 SHAN1_MOUSE (444-1849): 2.31e-28: 127: 13.34		DLGP1_MOUSE (1-992): 0: 1144: 45.61
+	Mm
		1160650 CSKI1_MOUSE (108-294): 7.37e-14: 79.8: 16.75		DLGP1_MOUSE (1-992): 0: 1144: 45.61
+	Rn
		957003 SHAN1_RAT (444-1849): 8.98e-28: 125: 13.34		DLGP2_RAT (1-992): 0: 1076: 42.21