Protein: IFIH1
Interferon-induced helicase C domain-containing protein 1 (EC 3.6.4.13) (Clinically amyopathic dermatomyositis autoantigen 140 kDa) (CADM-140 autoantigen) (Helicase with 2 CARD domains) (Helicard) (Interferon-induced with helicase C domain protein 1) (Melanoma differentiation-associated protein 5) (MDA-5) (Murabutide down-regulated protein) (RIG-I-like receptor 2) (RLR-2) (RNA helicase-DEAD box protein 116)

Gene: IFIH1
Organism: Homo sapiens
Interactions: 68
UniProt ID: Q9BYX4

Gene Ontology (top 5):
GO:0002753 - cytoplasmic pattern recognition receptor signaling pathway
GO:0003677 - DNA binding
GO:0003723 - RNA binding
GO:0003724 - RNA helicase activity
GO:0003725 - double-stranded RNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1278095

MAVS
Mitochondrial antiviral-signaling protein

13

8

Small-scale

0.979

High

1419395

IFIH1
Interferon-induced helicase C domain-containing protein 1

5

17

Small-scale

0.917

High

1245059

TRI65
E3 ubiquitin-protein ligase TRIM65

2

17

Small-scale

0.839

High

1385367

DHX58
ATP-dependent RNA helicase DHX58

3

18

Small-scale

0.827

High

425621

ISG15
Ubiquitin-like protein ISG15

1

11

Small-scale

0.715

High

1220774

RN123
E3 ubiquitin-protein ligase RNF123

1

8

Small-scale

0.713

High

287123

PRKRA
Interferon-inducible double-stranded RNA-dependent protein kinase activator A

1

20

Small-scale

0.691

High

1307224

RN135
E3 ubiquitin-protein ligase RNF135

1

18

Small-scale

0.647

High

1227402

A16L1
Autophagy-related protein 16-1

1

9

High-throughput

0.646

High

1389544

RN125
E3 ubiquitin-protein ligase RNF125

2

20

Small-scale

0.634

High

333512

MPZL1
Myelin protein zero-like protein 1

1

2

High-throughput

0.618

High

141650

DDX3X
ATP-dependent RNA helicase DDX3X

1

17

Small-scale

0.618

High

242830

PRKN
E3 ubiquitin-protein ligase parkin

1

19

Small-scale

0.618

High

1125216

TRI25
E3 ubiquitin/ISG15 ligase TRIM25

1

20

Small-scale

0.618

High

1419396

TRIM7
E3 ubiquitin-protein ligase TRIM7

1

8

Small-scale

0.618

High

1121515

KEAP1
Kelch-like ECH-associated protein 1

2

0

High-throughput

0.580

High

967951

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

2

9

Small-scale

0.571

High

1243368

TRI40
E3 ubiquitin ligase TRIM40

1

16

Small-scale

0.561

High

1308880

CCD50
Coiled-coil domain-containing protein 50

1

1

Small-scale

0.561

High

1419401

ZCHC3
Zinc finger CCHC domain-containing protein 3

1

8

Small-scale

0.561

High

1419405

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

12

Small-scale

0.561

High

575198

IDE
Insulin-degrading enzyme

1

1

High-throughput

0.536

High

1101013

G3BP1
Ras GTPase-activating protein-binding protein 1

1

12

High-throughput

0.536

High

1187018

TKFC
Triokinase/FMN cyclase

1

0

Small-scale

0.525

High

1049741

1433F
14-3-3 protein eta

1

8

Small-scale

0.515

High

1146988

PCBP2
Poly(rC)-binding protein 2

1

20

Small-scale

0.515

High

161835

RIOK3
Serine/threonine-protein kinase RIO3

1

8

Small-scale

0.506

High

423101

A4
Amyloid-beta precursor protein

1

6

High-throughput

0.501

High

317672

ATG12
Ubiquitin-like protein ATG12

1

1

Small-scale

0.500

High

1122550

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

10

Small-scale

0.500

High

1419398

ATG5
Autophagy protein 5

1

1

Small-scale

0.500

High

297865

PIAS2
E3 SUMO-protein ligase PIAS2

1

3

Small-scale

0.479

High

331293

KI20A
Kinesin-like protein KIF20A

1

8

High-throughput

0.479

High

822128

IFI27
Interferon alpha-inducible protein 27, mitochondrial

1

1

Small-scale

0.479

High

959047

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

1

2

High-throughput

0.479

High

986694

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

10

Small-scale

0.479

High

991417

SUMO1
Small ubiquitin-related modifier 1

1

7

Small-scale

0.479

High

1009807

IN35
Interferon-induced 35 kDa protein

1

1

Small-scale

0.479

High

1037816

IRF8
Interferon regulatory factor 8

1

7

Small-scale

0.479

High

1108117

SQSTM
Sequestosome-1

1

10

Small-scale

0.479

High

1141914

EEA1
Early endosome antigen 1

1

9

High-throughput

0.479

High

1146804

PCBP1
Poly(rC)-binding protein 1

1

20

Small-scale

0.479

High

1292487

NLRC5
Protein NLRC5

1

7

Small-scale

0.479

High

1336068

ARRD4
Arrestin domain-containing protein 4

1

4

Small-scale

0.479

High

1338351

FBX22
F-box only protein 22

1

1

High-throughput

0.479

High

1419397

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

18

Small-scale

0.479

High

1419399

TNKS2
Poly [ADP-ribose] polymerase tankyrase-2

1

1

Small-scale

0.479

High

1419400

AZI2
5-azacytidine-induced protein 2

1

1

Small-scale

0.479

High

1419403

UBP21
Ubiquitin carboxyl-terminal hydrolase 21

1

13

Small-scale

0.479

High

222392

TSN6
Tetraspanin-6

1

5

Small-scale

0.470

High

1005955

GTF2I
General transcription factor II-I

1

0

High-throughput

0.458

High

318215

DDHD2
Triacylglycerol hydrolase DDHD2

1

3

Small-scale

0.445

High

326020

UBR5
E3 ubiquitin-protein ligase UBR5

1

10

Small-scale

0.445

High

786826

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

9

Small-scale

0.445

High

1065411

SSRP1
FACT complex subunit SSRP1

1

10

Small-scale

0.445

High

1110406

KCC2G
Calcium/calmodulin-dependent protein kinase type II subunit gamma

1

2

Small-scale

0.445

High

1110556

KCC2D
Calcium/calmodulin-dependent protein kinase type II subunit delta

1

2

Small-scale

0.445

High

1290962

TAXB1
Tax1-binding protein 1

1

7

Small-scale

0.445

High

1401280

NACC1
Nucleus accumbens-associated protein 1

1

6

Small-scale

0.445

High

1419404

SP16H
FACT complex subunit SPT16

1

2

Small-scale

0.445

High

1419406

S23IP
SEC23-interacting protein

1

6

Small-scale

0.445

High

128472

PSMD9
26S proteasome non-ATPase regulatory subunit 9

1

0

Small-scale

0.426

High

344994

WIZ
Protein Wiz

1

0

Small-scale

0.426

High

1143517

PCM1
Pericentriolar material 1 protein

1

0

Small-scale

0.426

High

1208574

SMAG2
Protein Smaug homolog 2

1

0

Small-scale

0.426

High

1419402

ABHDA
Palmitoyl-protein thioesterase ABHD10, mitochondrial

1

0

Small-scale

0.426

High

50353

F168B
Myelin-associated neurite-outgrowth inhibitor

1

0

Small-scale

0.232

Low


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Last updated: 11Aug2025