HitPredict

Interactor 1: NALP7 (Q8WX94)
NACHT, LRR and PYD domains-containing protein 7 (Nucleotide-binding oligomerization domain protein 12) (PYRIN-containing APAF1-like protein 3)
Gene: NLRP7

Interactor 2: NALP2 (Q9NX02)
NACHT, LRR and PYD domains-containing protein 2 (Nucleotide-binding site protein 1) (PYRIN domain and NACHT domain-containing protein 1) (PYRIN-containing APAF1-like protein 2)
Gene: NLRP2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.38 1.00 0.618

The method score is based on:

Property Details
Experiments 37148315
Identification Methods anti tag coimmunoprecipitation
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains LRR_6~LRR_6, LRR_6~NACHT, NACHT~NACHT, NACHT~NLRC4_HD2, NACHT~NOD2_WH, NLRC4_HD2~NOD2_WH, PYRIN~PYRIN
Common GO terms GO:0005524 - ATP binding
GO:0005737 - cytoplasm
GO:0050727 - regulation of inflammatory response
Homologous interactions 18

Homologous interactions

Color coding for hit scores

1 980
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1 1062
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Last updated: 11Aug2025