Protein: NLRC4
NLR family CARD domain-containing protein 4 (CARD, LRR, and NACHT-containing protein) (CED-4-like protein Clan) (Caspase recruitment domain-containing protein 12) (Ice protease-activating factor) (Ipaf)

Gene: NLRC4
Organism: Homo sapiens
Interactions: 27
UniProt ID: Q9NPP4

Gene Ontology (top 5):
GO:0000287 - magnesium ion binding
GO:0002218 - activation of innate immune response
GO:0002221 - pattern recognition receptor signaling pathway
GO:0005524 - ATP binding
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

712893

CASP1
Caspase-1

6

20

Small-scale

0.938

High

1446611

ASC
Apoptosis-associated speck-like protein containing a CARD

6

20

Small-scale

0.931

High

1446609

NLRC4
NLR family CARD domain-containing protein 4

5

15

Small-scale

0.914

High

1438558

NOD2
Nucleotide-binding oligomerization domain-containing protein 2

2

20

Small-scale

0.776

High

1420416

NLRP1
NACHT, LRR and PYD domains-containing protein 1

2

19

Small-scale

0.754

High

1399394

NLRP3
NACHT, LRR and PYD domains-containing protein 3

1

20

Small-scale

0.665

High

1446612

NOD1
Nucleotide-binding oligomerization domain-containing protein 1

1

15

Small-scale

0.665

High

1132442

CASP8
Caspase-8

3

20

Small-scale

0.646

High

969064

PRS8
26S proteasome regulatory subunit 8

2

3

Small-scale

0.631

High

624156

E2AK2
Interferon-induced, double-stranded RNA-activated protein kinase

1

8

Small-scale

0.618

High

1093797

BIRC1
Baculoviral IAP repeat-containing protein 1

1

17

Small-scale

0.618

High

1096933

FADD
FAS-associated death domain protein

1

4

Small-scale

0.618

High

1398258

NALP4
NACHT, LRR and PYD domains-containing protein 4

1

19

Small-scale

0.618

High

1446610

TBK1
Serine/threonine-protein kinase TBK1

1

11

Small-scale

0.618

High

353903

BCL10
B-cell lymphoma/leukemia 10

1

0

Small-scale

0.586

High

390191

ALBU
Albumin

1

1

High-throughput

0.536

High

272757

BRE1B
E3 ubiquitin-protein ligase BRE1B

1

9

Small-scale

0.479

High

414677

P53
Cellular tumor antigen p53

1

1

Small-scale

0.479

High

476837

RSSA
Small ribosomal subunit protein uS2

1

2

High-throughput

0.479

High

651440

CBL
E3 ubiquitin-protein ligase CBL

1

4

Small-scale

0.479

High

1100419

TIF1B
Transcription intermediary factor 1-beta

1

4

Small-scale

0.479

High

1245067

TRI65
E3 ubiquitin-protein ligase TRIM65

1

20

Small-scale

0.479

High

1280522

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

2

Small-scale

0.479

High

1446613

SGT1
Protein SGT1 homolog

1

13

Small-scale

0.479

High

908078

XK
Endoplasmic reticulum membrane adapter protein XK

1

0

Small-scale

0.458

High

914216

EFNA3
Ephrin-A3

1

0

High-throughput

0.458

High


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Last updated: 11Aug2025