HitPredict

Interactor 1: CUL5 (Q93034)
Cullin-5 (CUL-5) (Vasopressin-activated calcium-mobilizing receptor 1) (VACM-1)
Gene: CUL5

Interactor 2: ASB2 (Q96Q27)
Ankyrin repeat and SOCS box protein 2 (ASB-2)
Gene: ASB2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.89	1.00	0.945

Property	Details
Experiments	21119685, 28514442, 33961781, 16325183, 19300455, 24044920
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Ank_2~Cullin, Cullin~SOCS_box
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0016567 - protein ubiquitination GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 780 Hs			1 635
+	Hs
		1112665 CUL1_HUMAN (11-780): 0: 746: 27.84		ASB2_HUMAN (1-635): 2.49e-155: 463: 100.00
+	Hs
		1115010 CUL4A_HUMAN (16-780): 0: 743: 24.48		ASB2_HUMAN (1-635): 2.49e-155: 463: 100.00
+	Hs
		592933 CUL3_HUMAN (8-780): 0: 753: 22.96		ANK1_HUMAN (30-631): 1.17e-129: 421: 18.75
+	Hs
		1112963 CUL2_HUMAN (6-780): 0: 697: 26.36		ASB2_HUMAN (1-635): 2.49e-155: 463: 100.00
+	Hs
		1091393 CUL3_HUMAN (8-780): 0: 753: 22.96		ANK3_HUMAN (2-356): 1.73e-94: 321: 21.41
+	Hs
		1091394 CUL4A_HUMAN (16-780): 0: 743: 24.48		ANK3_HUMAN (2-356): 1.73e-94: 321: 21.41
+	Hs
		1371859 CUL5_HUMAN (1-780): 0: 791: 100.00		TNKS2_HUMAN (2-414): 9.75e-78: 270: 18.14
+	Hs
		66450 CUL5_HUMAN (1-780): 0: 791: 100.00		ASB14_HUMAN (10-408): 1.76e-60: 213: 19.71
+	Hs
		1361052 CUL5_HUMAN (1-780): 0: 791: 100.00		ASB15_HUMAN (3-332): 1.8e-56: 202: 17.99
+	Hs
		1113716 CUL3_HUMAN (8-780): 0: 753: 22.96		ANR52_HUMAN (206-571): 1.77e-64: 231: 21.45
+	Hs
		1371912 CUL5_HUMAN (1-780): 0: 791: 100.00		ASB3_HUMAN (21-330): 8.21e-45: 169: 18.18
+	Hs
		1115171 CUL4A_HUMAN (16-780): 0: 743: 24.48		ASB3_HUMAN (21-330): 8.21e-45: 169: 18.18
+	Hs
		177215 CUL3_HUMAN (8-780): 0: 753: 22.96		ANR28_HUMAN (2-258): 5.06e-39: 156: 13.31
+	Hs
		1114688 CUL3_HUMAN (8-780): 0: 753: 22.96		INVS_HUMAN (309-631): 3.5e-30: 128: 12.72
+	Hs
		1113629 CUL3_HUMAN (8-780): 0: 753: 22.96		ANKH1_HUMAN (394-613): 1.51e-27: 121: 12.93