HitPredict

Interactor 1: CUL5 (Q93034)
Cullin-5 (CUL-5) (Vasopressin-activated calcium-mobilizing receptor 1) (VACM-1)
Gene: CUL5

Interactor 2: APC11 (Q9NYG5)
Anaphase-promoting complex subunit 11 (APC11) (Cyclosome subunit 11) (Hepatocellular carcinoma-associated RING finger protein)
Gene: ANAPC11

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.57	1.00	0.757

Property	Details
Experiments	31253590, 10230407
Identification Methods	affinity chromatography technology, two hybrid
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	Cullin~zf-ANAPC11
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0016567 - protein ubiquitination GO:0070979 - protein K11-linked ubiquitination
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 780 Hs			1 84
+	Hs
		983919 CUL5_HUMAN (1-780): 0: 791: 100.00		RBX1_HUMAN (2-84): 6.08e-29: 101: 37.50
+	Hs
		1371889 CUL5_HUMAN (1-780): 0: 791: 100.00		RBX2_HUMAN (3-84): 1.11e-22: 85.5: 34.52
+	At
		1373857 CUL3A_ARATH (16-780): 0: 757: 23.18		RBX1A_ARATH (2-84): 3.27e-28: 99.8: 37.50
+	Hs
		983793 CUL3_HUMAN (8-780): 0: 753: 22.96		RBX1_HUMAN (2-84): 6.08e-29: 101: 37.50
+	Hs
		983791 CUL1_HUMAN (11-780): 0: 746: 27.84		RBX1_HUMAN (2-84): 6.08e-29: 101: 37.50
+	Mm
		984057 CUL1_MOUSE (11-780): 0: 746: 27.84		RBX1_MOUSE (2-84): 6.08e-29: 101: 37.50
+	Mm
		984047 CUL4A_MOUSE (16-780): 0: 744: 24.48		RBX1_MOUSE (2-84): 6.08e-29: 101: 37.50
+	Hs
		983794 CUL4A_HUMAN (16-780): 0: 743: 24.48		RBX1_HUMAN (2-84): 6.08e-29: 101: 37.50
+	At
		1373853 CUL3B_ARATH (16-780): 0: 743: 23.18		RBX1A_ARATH (2-84): 3.27e-28: 99.8: 37.50
+	Hs
		1114533 CUL3_HUMAN (8-780): 0: 753: 22.96		RBX2_HUMAN (3-84): 1.11e-22: 85.5: 34.52
+	Mm
		58988 CUL4B_MOUSE (16-780): 0: 735: 25.26		RBX1_MOUSE (2-84): 6.08e-29: 101: 37.50
+	Hs
		983795 CUL4B_HUMAN (16-780): 0: 735: 25.39		RBX1_HUMAN (2-84): 6.08e-29: 101: 37.50
+	Dm
		1304398 Q8IP45_DROME (5-780): 0: 734: 22.73		RBX1A_DROME (2-84): 1.23e-28: 100: 37.50
+	Hs
		1112757 CUL1_HUMAN (11-780): 0: 746: 27.84		RBX2_HUMAN (3-84): 1.11e-22: 85.5: 34.52
+	Mm
		1189324 CUL4A_MOUSE (16-780): 0: 744: 24.48		RBX2_MOUSE (3-84): 1.2e-22: 85.5: 34.52
+	Dm
		1304379 Q8IP45_DROME (5-780): 0: 734: 22.73		RBX1B_DROME (2-84): 3.26e-26: 94.8: 34.48
+	Hs
		1115114 CUL4A_HUMAN (16-780): 0: 743: 24.48		RBX2_HUMAN (3-84): 1.11e-22: 85.5: 34.52
+	Hs
		1115472 CUL4B_HUMAN (16-780): 0: 735: 25.39		RBX2_HUMAN (3-84): 1.11e-22: 85.5: 34.52
+	At
		1373851 CUL1_ARATH (8-780): 0: 718: 24.34		RBX1A_ARATH (2-84): 3.27e-28: 99.8: 37.50
+	Hs
		317840 CUL3_HUMAN (8-780): 0: 753: 22.96		LTN1_HUMAN (18-80): 6.05e-13: 63.9: 23.81