HitPredict

Interactor 1: RNF34 (Q969K3)
E3 ubiquitin-protein ligase RNF34 (EC 2.3.2.27) (Caspase regulator CARP1) (Caspases-8 and -10-associated RING finger protein 1) (CARP-1) (FYVE-RING finger protein Momo) (Human RING finger homologous to inhibitor of apoptosis protein) (hRFI) (RING finger protein 34) (RING finger protein RIFF) (RING-type E3 ubiquitin transferase RNF34)
Gene: RNF34

Interactor 2: UBE2F (Q969M7)
NEDD8-conjugating enzyme UBE2F (EC 2.3.2.34) (NEDD8 carrier protein UBE2F) (NEDD8 protein ligase UBE2F) (NEDD8-conjugating enzyme 2) (RING-type E3 NEDD8 transferase UBE2F) (Ubiquitin-conjugating enzyme E2 F)
Gene: UBE2F

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	1.00	0.698

Property	Details
Experiments	19549727
Identification Methods	two hybrid, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	UQ_con~zf-C3HC4_3
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 372 Hs			1 185
+	Hs
		906729 RNF34_HUMAN (1-372): 1.77e-136: 395: 100.00		UB2D1_HUMAN (32-184): 7.15e-76: 225: 32.03
+	Hs
		982269 RNF34_HUMAN (1-372): 1.77e-136: 395: 100.00		UB2D2_HUMAN (32-184): 5.09e-76: 225: 32.03
+	Hs
		957152 RNF34_HUMAN (1-372): 1.77e-136: 395: 100.00		UB2D3_HUMAN (32-184): 3.2e-74: 221: 31.37
+	Hs
		909363 RNF34_HUMAN (1-372): 1.77e-136: 395: 100.00		UB2E1_HUMAN (9-184): 8.91e-72: 217: 27.27
+	Hs
		906723 RFFL_HUMAN (8-372): 1.78e-115: 341: 42.78		UB2D1_HUMAN (32-184): 7.15e-76: 225: 32.03
+	Hs
		982264 RFFL_HUMAN (8-372): 1.78e-115: 341: 42.78		UB2D2_HUMAN (32-184): 5.09e-76: 225: 32.03
+	Hs
		957149 RFFL_HUMAN (8-372): 1.78e-115: 341: 42.78		UB2D3_HUMAN (32-184): 3.2e-74: 221: 31.37
+	Hs
		906737 BIRC7_HUMAN (135-372): 5.51e-35: 132: 17.31		UB2D1_HUMAN (32-184): 7.15e-76: 225: 32.03
+	Hs
		982277 BIRC7_HUMAN (135-372): 5.51e-35: 132: 17.31		UB2D2_HUMAN (32-184): 5.09e-76: 225: 32.03
+	Hs
		957158 BIRC7_HUMAN (135-372): 5.51e-35: 132: 17.31		UB2D3_HUMAN (32-184): 3.2e-74: 221: 31.37
+	Hs
		909368 BIRC7_HUMAN (135-372): 5.51e-35: 132: 17.31		UB2E1_HUMAN (9-184): 8.91e-72: 217: 27.27
+	Hs
		1022814 XIAP_HUMAN (158-372): 1.96e-25: 108: 17.63		UB2D4_HUMAN (32-184): 1.44e-76: 227: 32.68
+	Hs
		906644 XIAP_HUMAN (158-372): 1.96e-25: 108: 17.63		UB2D1_HUMAN (32-184): 7.15e-76: 225: 32.03
+	Hs
		982166 XIAP_HUMAN (158-372): 1.96e-25: 108: 17.63		UB2D2_HUMAN (32-184): 5.09e-76: 225: 32.03
+	Dm
		683044 DIAP1_DROME (222-372): 3.53e-25: 107: 15.23		UBCD1_DROME (32-184): 1.28e-75: 225: 32.03
+	Hs
		1022776 XIAP_HUMAN (158-372): 1.96e-25: 108: 17.63		UB2E2_HUMAN (9-184): 1.58e-73: 221: 27.27
+	Hs
		957062 XIAP_HUMAN (158-372): 1.96e-25: 108: 17.63		UB2D3_HUMAN (32-184): 3.2e-74: 221: 31.37
+	Hs
		909305 XIAP_HUMAN (158-372): 1.96e-25: 108: 17.63		UB2E1_HUMAN (9-184): 8.91e-72: 217: 27.27
+	Hs
		884315 XIAP_HUMAN (158-372): 1.96e-25: 108: 17.63		UBE2A_HUMAN (30-185): 4.23e-67: 203: 22.44
+	Dm
		1173285 DIAP1_DROME (222-372): 3.53e-25: 107: 15.23		UBC2M_DROME (9-181): 7.15e-34: 120: 38.73