HitPredict

Interactor 1: UB2D2 (P62837)
Ubiquitin-conjugating enzyme E2 D2 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme D2) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme D2) (Ubiquitin carrier protein D2) (Ubiquitin-conjugating enzyme E2(17)KB 2) (Ubiquitin-conjugating enzyme E2-17 kDa 2) (Ubiquitin-protein ligase D2) (p53-regulated ubiquitin-conjugating enzyme 1)
Gene: UBE2D2

Interactor 2: XIAP (P98170)
E3 ubiquitin-protein ligase XIAP (EC 2.3.2.27) (Baculoviral IAP repeat-containing protein 4) (IAP-like protein) (ILP) (hILP) (Inhibitor of apoptosis protein 3) (IAP-3) (hIAP-3) (hIAP3) (RING-type E3 ubiquitin transferase XIAP) (X-linked inhibitor of apoptosis protein) (X-linked IAP)
Gene: XIAP

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.94	1.00	0.971

Property	Details
Experiments	19549727, 11724934, 12525502, 25801170, 27569044, 29020630, 21113135, 23259674
Identification Methods	pull down, affinity chromatography technology, two hybrid, two hybrid array, enzymatic study
Interaction Type	direct interaction, physical association, ubiquitination reaction

Property	Details
Interacting Pfam domains	UQ_con~zf-C3HC4_3
Common GO terms	GO:0004842 - ubiquitin-protein transferase activity GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0061630 - ubiquitin protein ligase activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 147 Hs			1 497
+	Hs
		1022814 UB2D4_HUMAN (1-147): 3.4e-83: 242: 93.20		XIAP_HUMAN (1-497): 0: 568: 100.00
+	Hs
		906644 UB2D1_HUMAN (1-147): 1.1e-82: 241: 89.12		XIAP_HUMAN (1-497): 0: 568: 100.00
+	Hs
		906658 UB2D1_HUMAN (1-147): 1.1e-82: 241: 89.12		BIRC2_HUMAN (3-497): 5.09e-81: 265: 23.31
+	Hs
		906657 UB2D1_HUMAN (1-147): 1.1e-82: 241: 89.12		BIRC3_HUMAN (150-394): 5.3e-41: 157: 23.94
+	Hs
		906737 UB2D1_HUMAN (1-147): 1.1e-82: 241: 89.12		BIRC7_HUMAN (14-155): 1.18e-36: 138: 21.83
+	Hs
		1399328 UB2D4_HUMAN (1-147): 3.4e-83: 242: 93.20		BIRC8_HUMAN (160-264): 3.05e-31: 122: 30.48
+	Hs
		906750 UB2D1_HUMAN (1-147): 1.1e-82: 241: 89.12		BIRC8_HUMAN (160-264): 3.05e-31: 122: 30.48
+	Hs
		906793 UB2D1_HUMAN (1-147): 1.1e-82: 241: 89.12		BIRC6_HUMAN (258-442): 9.16e-26: 113: 18.78
+	Hs
		1248454 UB2D4_HUMAN (1-147): 3.4e-83: 242: 93.20		LRSM1_HUMAN (330-497): 1.4e-24: 109: 18.45
+	Hs
		1417857 UB2D4_HUMAN (1-147): 3.4e-83: 242: 93.20		RNF26_HUMAN (320-496): 5.37e-25: 109: 14.13
+	Hs
		906681 UB2D1_HUMAN (1-147): 1.1e-82: 241: 89.12		LRSM1_HUMAN (330-497): 1.4e-24: 109: 18.45
+	Hs
		906768 UB2D1_HUMAN (1-147): 1.1e-82: 241: 89.12		RNF26_HUMAN (320-496): 5.37e-25: 109: 14.13
+	At
		762748 UBC8_ARATH (1-147): 1.51e-82: 240: 80.27		LUL3_ARATH (335-494): 1.24e-24: 107: 19.41
+	Hs
		1361437 UB2D4_HUMAN (1-147): 3.4e-83: 242: 93.20		MYLIP_HUMAN (430-496): 3.8e-23: 103: 35.82
+	Hs
		906722 UB2D1_HUMAN (1-147): 1.1e-82: 241: 89.12		MYLIP_HUMAN (430-496): 3.8e-23: 103: 35.82
+	Hs
		906729 UB2D1_HUMAN (1-147): 1.1e-82: 241: 89.12		RNF34_HUMAN (440-497): 1.44e-18: 89.2: 37.93
+	Hs
		906723 UB2D1_HUMAN (1-147): 1.1e-82: 241: 89.12		RFFL_HUMAN (446-497): 3.51e-18: 88: 44.23
+	Hs
		1295603 UB2D4_HUMAN (1-147): 3.4e-83: 242: 93.20		MIB1_HUMAN (311-494): 5.84e-16: 83.1: 15.76
+	Hs
		906699 UB2D1_HUMAN (1-147): 1.1e-82: 241: 89.12		MIB1_HUMAN (311-494): 5.84e-16: 83.1: 15.76
+	Hs
		906733 UB2D1_HUMAN (1-147): 1.1e-82: 241: 89.12		MIB2_HUMAN (437-496): 2.01e-10: 65.3: 35.00