HitPredict

Interactor 1: FERM2 (Q96AC1)
Fermitin family homolog 2 (Kindlin-2) (Mitogen-inducible gene 2 protein) (MIG-2) (Pleckstrin homology domain-containing family C member 1) (PH domain-containing family C member 1)
Gene: FERMT2

Interactor 2: ALK (Q9UM73)
ALK tyrosine kinase receptor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD antigen CD246)
Gene: ALK

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	34273398
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	FERM_M~PK_Tyr_Ser-Thr, PH~PK_Tyr_Ser-Thr
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 680 Hs			1 1620
+	Hs
		1289403 URP2_HUMAN (3-678): 0: 968: 52.55		ALK_HUMAN (1-1620): 0: 1901: 100.00
+	Hs
		1462014 TLN2_HUMAN (485-670): 8.25e-55: 205: 22.55		ALK_HUMAN (1-1620): 0: 1901: 100.00
+	Hs
		710875 FERM2_HUMAN (1-680): 0: 1112: 100.00		EPHB2_HUMAN (938-1436): 1.28e-127: 427: 23.26
+	Hs
		465607 FERM2_HUMAN (1-680): 0: 1112: 100.00		IGF1R_HUMAN (1037-1385): 8.56e-111: 386: 39.77
+	Hs
		412402 FERM2_HUMAN (1-680): 0: 1112: 100.00		NTRK1_HUMAN (1111-1392): 5.08e-62: 230: 42.07
+	Hs
		1157025 FERM2_HUMAN (1-680): 0: 1112: 100.00		NTRK3_HUMAN (1093-1375): 2.7e-59: 223: 39.03
+	Hs
		541628 FERM2_HUMAN (1-680): 0: 1112: 100.00		FGFR1_HUMAN (1110-1403): 6.78e-55: 209: 38.07
+	Hs
		464088 TLN1_HUMAN (485-670): 1.38e-56: 211: 23.15		RET_HUMAN (804-1477): 5.87e-139: 460: 23.15
+	Hs
		1125307 TLN1_HUMAN (485-670): 1.38e-56: 211: 23.15		FAK2_HUMAN (1054-1518): 3.57e-109: 374: 27.45
+	Hs
		412865 TLN1_HUMAN (485-670): 1.38e-56: 211: 23.15		NTRK1_HUMAN (1111-1392): 5.08e-62: 230: 42.07