HitPredict

Interactor 1: MP2K3 (O09110)
Dual specificity mitogen-activated protein kinase kinase 3 (MAP kinase kinase 3) (MAPKK 3) (EC 2.7.12.2) (MAPK/ERK kinase 3) (MEK 3)
Gene: Map2k3

Interactor 2: MK14 (P47811)
Mitogen-activated protein kinase 14 (MAP kinase 14) (MAPK 14) (EC 2.7.11.24) (CRK1) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha)
Gene: Mapk14

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.41 1.00 0.647

The method score is based on:

Property Details
Experiments 15644321
Identification Methods enzymatic study
Interaction Type direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains Pkinase~Pkinase
Common GO terms GO:0000165 - MAPK cascade
GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding
GO:0035331 - negative regulation of hippo signaling
GO:0035924 - cellular response to vascular endothelial growth factor stimulus
and 3 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 347
Mm

1 360
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+ At
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024