Protein: KCTD6
BTB/POZ domain-containing protein KCTD6 (KCASH3 protein) (Potassium channel tetramerization domain-containing protein 6)

Gene: KCTD6
Organism: Homo sapiens
Interactions: 72
UniProt ID: Q8NC69

Gene Ontology (top 5):
GO:0005829 - cytosol
GO:0006511 - ubiquitin-dependent protein catabolic process
GO:0016567 - protein ubiquitination
GO:0030506 - ankyrin binding
GO:0031430 - M band

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1113725

CUL3
Cullin-3

13

20

Small-scale

0.982

High

1335231

KCTD6
BTB/POZ domain-containing protein KCTD6

5

19

Small-scale

0.925

High

1229415

KCD11
BTB/POZ domain-containing protein KCTD11

2

17

Small-scale

0.789

High

140367

SDCB1
Syntenin-1

3

20

High-throughput

0.675

High

254187

CTND1
Catenin delta-1

3

14

High-throughput

0.675

High

1126624

GRB7
Growth factor receptor-bound protein 7

3

13

High-throughput

0.675

High

1335256

CDC23
Cell division cycle protein 23 homolog

3

3

High-throughput

0.675

High

945518

GSDMD
Gasdermin-D

4

0

High-throughput

0.668

High

957443

UBC12
NEDD8-conjugating enzyme Ubc12

3

9

High-throughput

0.667

High

1335235

PRP31
U4/U6 small nuclear ribonucleoprotein Prp31

5

1

High-throughput

0.662

High

1063987

ECHP
Peroxisomal bifunctional enzyme

3

4

High-throughput

0.640

High

1102494

IFIT5
Interferon-induced protein with tetratricopeptide repeats 5

2

4

High-throughput

0.628

High

1335233

LNX1
E3 ubiquitin-protein ligase LNX

2

20

High-throughput

0.628

High

775204

FUS
RNA-binding protein FUS

2

10

High-throughput

0.621

High

1194643

KCD21
BTB/POZ domain-containing protein KCTD21

1

19

Small-scale

0.618

High

907500

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

2

6

Small-scale

0.611

High

336724

BAG4
BAG family molecular chaperone regulator 4

2

4

High-throughput

0.606

High

680955

PSA1
Proteasome subunit alpha type-1

2

12

High-throughput

0.606

High

1048918

REL
Proto-oncogene c-Rel

2

5

High-throughput

0.606

High

1335241

NTAQ1
Protein N-terminal glutamine amidohydrolase

2

8

High-throughput

0.606

High

1335242

AP4AT
AP-4 complex accessory subunit Tepsin

2

1

High-throughput

0.606

High

1335244

TBD2A
TBC1 domain family member 2A

2

9

High-throughput

0.606

High

1335250

PICK1
PRKCA-binding protein

2

3

High-throughput

0.606

High

410947

ERBB2
Receptor tyrosine-protein kinase erbB-2

2

7

High-throughput

0.576

High

569593

CATE
Cathepsin E

2

1

High-throughput

0.574

High

1335237

GLMN
Glomulin

2

1

High-throughput

0.574

High

1335249

ZFYV1
Zinc finger FYVE domain-containing protein 1

2

5

High-throughput

0.574

High

555722

ACTN1
Alpha-actinin-1

1

17

High-throughput

0.573

High

1104974

PPIG
Peptidyl-prolyl cis-trans isomerase G

1

5

High-throughput

0.573

High

364163

MOS
Proto-oncogene serine/threonine-protein kinase mos

2

1

High-throughput

0.553

High

1331067

TEANC
Transcription elongation factor A N-terminal and central domain-containing protein

2

4

High-throughput

0.553

High

592945

ANK1
Ankyrin-1

1

11

Small-scale

0.552

High

1335257

UBP21
Ubiquitin carboxyl-terminal hydrolase 21

1

5

Small-scale

0.552

High

1013420

LACTB
Serine beta-lactamase-like protein LACTB, mitochondrial

1

2

High-throughput

0.536

High

1094375

CSN1
COP9 signalosome complex subunit 1

1

6

High-throughput

0.536

High

1250496

RBP10
Ran-binding protein 10

1

8

High-throughput

0.536

High

1272706

MAEA
E3 ubiquitin-protein transferase MAEA

1

6

High-throughput

0.536

High

1307884

ARMC8
Armadillo repeat-containing protein 8

1

3

High-throughput

0.536

High

1335236

CSN5
COP9 signalosome complex subunit 5

1

4

High-throughput

0.536

High

1335240

RMD5B
E3 ubiquitin-protein transferase RMND5B

1

5

High-throughput

0.536

High

1335243

RANB9
Ran-binding protein 9

1

9

High-throughput

0.536

High

1335245

NAA50
N-alpha-acetyltransferase 50

1

1

High-throughput

0.536

High

1335248

RMD5A
E3 ubiquitin-protein transferase RMND5A

1

5

High-throughput

0.536

High

1335251

GID8
Glucose-induced degradation protein 8 homolog

1

6

High-throughput

0.536

High

1335258

MKLN1
Muskelin

1

4

High-throughput

0.536

High

1335252

TBA8
Tubulin alpha-8 chain

2

13

High-throughput

0.535

High

1309292

GID4
Glucose-induced degradation protein 4 homolog

1

0

High-throughput

0.513

High

884837

PPM1F
Protein phosphatase 1F

1

0

High-throughput

0.493

High

50373

PXDNL
Probable oxidoreductase PXDNL

1

5

High-throughput

0.489

High

51463

FSD2
Fibronectin type III and SPRY domain-containing protein 2

1

11

High-throughput

0.489

High

134338

RPOM
DNA-directed RNA polymerase, mitochondrial

1

1

High-throughput

0.489

High

1335238

OTUB2
Ubiquitin thioesterase OTUB2

1

1

High-throughput

0.489

High

1335239

ZMY19
Zinc finger MYND domain-containing protein 19

1

3

High-throughput

0.489

High

1335259

RBM7
RNA-binding protein 7

1

6

High-throughput

0.489

High

1061539

ACTN3
Alpha-actinin-3

1

16

High-throughput

0.481

High

1138408

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

2

High-throughput

0.479

High

1217417

OBSCN
Obscurin

1

7

Small-scale

0.479

High

1335253

HECW2
E3 ubiquitin-protein ligase HECW2

1

9

High-throughput

0.479

High

73657

B2R8Y4
cDNA, FLJ94117, highly similar to Homo sapiens actinin, alpha 3

1

16

High-throughput

0.470

High

1068825

GOG8D
Putative golgin subfamily A member 8D

1

13

High-throughput

0.470

High

1155550

EZH2
Histone-lysine N-methyltransferase EZH2

1

4

High-throughput

0.437

High

1335232

TIP
T-cell immunomodulatory protein

1

1

High-throughput

0.437

High

1335255

DS13B
Dual specificity protein phosphatase 13B

1

2

High-throughput

0.437

High

1335234

ZCH10
Zinc finger CCHC domain-containing protein 10

1

0

High-throughput

0.299

High

1335246

F124B
Protein FAM124B

1

0

High-throughput

0.299

High

1335247

CH033
UPF0488 protein C8orf33

1

0

High-throughput

0.299

High

977137

YPEL5
Protein yippee-like 5

1

0

High-throughput

0.279

Low

1198309

TIGD5
Tigger transposable element-derived protein 5

1

0

High-throughput

0.279

Low

1240243

ZCHC8
Zinc finger CCHC domain-containing protein 8

1

0

High-throughput

0.279

Low

1335254

GGE2D
G antigen 2D

1

0

High-throughput

0.279

Low

1137395

SUZ12
Polycomb protein SUZ12

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025