HitPredict

Interactor 1: RNF5 (Q99942)
E3 ubiquitin-protein ligase RNF5 (EC 2.3.2.27) (RING finger protein 5) (Ram1 homolog) (HsRma1)
Gene: RNF5

Interactor 2: UBE2Z (Q9H832)
Ubiquitin-conjugating enzyme E2 Z (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme Z) (Uba6-specific E2 conjugating enzyme 1) (Use1) (Ubiquitin carrier protein Z) (Ubiquitin-protein ligase Z)
Gene: UBE2Z

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	1.00	0.698

Property	Details
Experiments	19549727
Identification Methods	two hybrid, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	UQ_con~zf-C3HC4_3
Common GO terms	GO:0006511 - ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 180 Hs			1 354
+	Dm
		912347 Q9VXP1_DROME (3-178): 1.4e-54: 175: 47.73		UBCD2_DROME (16-253): 2.54e-75: 233: 25.00
+	Dm
		912331 Q8IR26_DROME (3-179): 4.44e-50: 164: 48.32		UBCD2_DROME (16-253): 2.54e-75: 233: 25.00
+	Dm
		683063 Q9VXP1_DROME (3-178): 1.4e-54: 175: 47.73		UBCD1_DROME (99-253): 2.8e-71: 220: 34.40
+	Hs
		1408213 RNF5_HUMAN (1-164): 1.58e-52: 167: 100.00		UB2D4_HUMAN (99-253): 4.06e-73: 225: 33.12
+	Hs
		982298 RNF5_HUMAN (1-164): 1.58e-52: 167: 100.00		UB2D2_HUMAN (99-253): 1.2e-72: 223: 34.40
+	Hs
		906761 RNF5_HUMAN (1-164): 1.58e-52: 167: 100.00		UB2D1_HUMAN (99-253): 1e-71: 221: 31.85
+	Hs
		957179 RNF5_HUMAN (1-164): 1.58e-52: 167: 100.00		UB2D3_HUMAN (99-253): 2.57e-71: 220: 34.40
+	Dm
		1440675 Q9VXP1_DROME (3-178): 1.4e-54: 175: 47.73		Q9I7T6_DROME (15-253): 7.48e-65: 211: 23.39
+	Dm
		683050 Q8IR26_DROME (3-179): 4.44e-50: 164: 48.32		UBCD1_DROME (99-253): 2.8e-71: 220: 34.40
+	Hs
		982286 RN185_HUMAN (17-179): 1.45e-49: 160: 60.98		UB2D2_HUMAN (99-253): 1.2e-72: 223: 34.40
+	Hs
		906746 RN185_HUMAN (17-179): 1.45e-49: 160: 60.98		UB2D1_HUMAN (99-253): 1e-71: 221: 31.85
+	Hs
		957167 RN185_HUMAN (17-179): 1.45e-49: 160: 60.98		UB2D3_HUMAN (99-253): 2.57e-71: 220: 34.40
+	Dm
		1305888 Q8IR26_DROME (3-179): 4.44e-50: 164: 48.32		Q9I7T6_DROME (15-253): 7.48e-65: 211: 23.39
+	Mm
		204845 RNF5_MOUSE (1-164): 9.49e-53: 168: 97.56		UB2E3_MOUSE (74-253): 3.27e-65: 207: 27.47
+	Hs
		1381191 RNF5_HUMAN (1-164): 1.58e-52: 167: 100.00		UB2E3_HUMAN (74-253): 3.27e-65: 207: 27.47
+	Hs
		1397287 RNF5_HUMAN (1-164): 1.58e-52: 167: 100.00		UB2E2_HUMAN (44-253): 1.95e-65: 207: 24.53
+	Hs
		909383 RNF5_HUMAN (1-164): 1.58e-52: 167: 100.00		UB2E1_HUMAN (82-253): 3.39e-65: 206: 27.01
+	Hs
		1381183 RN185_HUMAN (17-179): 1.45e-49: 160: 60.98		UB2E3_HUMAN (74-253): 3.27e-65: 207: 27.47
+	Hs
		909374 RN185_HUMAN (17-179): 1.45e-49: 160: 60.98		UB2E1_HUMAN (82-253): 3.39e-65: 206: 27.01
+	Hs
		957826 RNF5_HUMAN (1-164): 1.58e-52: 167: 100.00		UBE2N_HUMAN (103-226): 3.79e-18: 82: 36.29