HitPredict

Interactor 1: LZTS2 (Q9BRK4)
Leucine zipper putative tumor suppressor 2 (hLZTS2) (Protein LAPSER1)
Gene: LZTS2

Interactor 2: LZTS1 (Q9Y250)
Leucine zipper putative tumor suppressor 1 (F37/esophageal cancer-related gene-coding leucine-zipper motif) (Fez1)
Gene: LZTS1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.89	0.60	0.732

Property	Details
Experiments	26186194, 28514442, 29395067, 33961781, 35271311, unassigned3799
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 669 Hs			1 596
+	Hs
		244898 LZTS2_HUMAN (1-669): 3.78e-58: 209: 100.00		LZTS3_HUMAN (99-596): 1.09e-36: 147: 35.68
+	Hs
		1364980 LZTS2_HUMAN (1-669): 3.78e-58: 209: 100.00		TSC1_HUMAN (7-555): 1.36e-33: 139: 11.90
+	Hs
		772986 LZTS2_HUMAN (1-669): 3.78e-58: 209: 100.00		MYH9_HUMAN (281-595): 4.19e-13: 75: 11.69
+	Hs
		1081716 LZTS2_HUMAN (1-669): 3.78e-58: 209: 100.00		CGNL1_HUMAN (203-595): 1.34e-11: 70: 14.71
+	Hs
		1365584 LZTS2_HUMAN (1-669): 3.78e-58: 209: 100.00		MY18A_HUMAN (240-536): 3.64e-11: 68.5: 12.58
+	Hs
		1226247 LZTS2_HUMAN (1-669): 3.78e-58: 209: 100.00		CP135_HUMAN (242-539): 1.03e-10: 66.8: 20.19
+	Hs
		587788 LZTS2_HUMAN (1-669): 3.78e-58: 209: 100.00		DESP_HUMAN (275-570): 1.98e-10: 66.5: 16.23
+	Hs
		1154087 ITSN1_HUMAN (110-668): 3.41e-29: 126: 13.48		ITSN1_HUMAN (55-594): 2.66e-32: 135: 13.50
+	Hs
		1289064 PHLB1_HUMAN (8-631): 1.93e-26: 117: 14.83		TSC1_HUMAN (7-555): 1.36e-33: 139: 11.90
+	Hs
		175995 N4BP3_HUMAN (17-640): 2.91e-35: 142: 27.16		MYO5C_HUMAN (213-532): 5.51e-15: 80.8: 13.58
+	Hs
		244889 LZTS3_HUMAN (1-669): 8.99e-32: 133: 31.33		CP135_HUMAN (242-539): 1.03e-10: 66.8: 20.19
+	Hs
		1217526 MRCKA_HUMAN (139-666): 6.11e-24: 110: 11.84		MRCKA_HUMAN (154-578): 4.71e-16: 84.2: 13.67
+	Hs
		1217527 MRCKA_HUMAN (139-666): 6.11e-24: 110: 11.84		CP135_HUMAN (242-539): 1.03e-10: 66.8: 20.19
+	Rn
		236526 MRCKA_RAT (139-660): 1.84e-23: 108: 11.85		MRCKA_RAT (177-520): 2.79e-11: 68.8: 10.03
+	Hs
		1217577 MRCKA_HUMAN (139-666): 6.11e-24: 110: 11.84		MRCKB_HUMAN (208-510): 7.22e-09: 61.1: 12.46
+	Rn
		236530 MRCKA_RAT (139-660): 1.84e-23: 108: 11.85		MRCKB_RAT (170-510): 4.67e-09: 61.9: 11.97
+	Hs
		556902 MYH9_HUMAN (40-669): 1.08e-16: 86.6: 10.13		MYH7_HUMAN (163-595): 1.17e-13: 76.5: 12.03
+	Hs
		772644 MYH9_HUMAN (40-669): 1.08e-16: 86.6: 10.13		MYH9_HUMAN (281-595): 4.19e-13: 75: 11.69
+	Hs
		772645 MYH9_HUMAN (40-669): 1.08e-16: 86.6: 10.13		MYH10_HUMAN (133-527): 9.88e-11: 67.3: 11.66