HitPredict

Interactor 1: NFIP1 (Q9BT67)
NEDD4 family-interacting protein 1 (Breast cancer-associated protein SGA-1M) (NEDD4 WW domain-binding protein 5) (Putative MAPK-activating protein PM13) (Putative NF-kappa-B-activating protein 164) (Putative NFKB and MAPK-activating protein)
Gene: NDFIP1

Interactor 2: SMUF1 (Q9HCE7)
E3 ubiquitin-protein ligase SMURF1 (hSMURF1) (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase SMURF1) (SMAD ubiquitination regulatory factor 1) (SMAD-specific E3 ubiquitin-protein ligase 1)
Gene: SMURF1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	23087404
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0006511 - ubiquitin-dependent protein catabolic process
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 221 Hs			1 757
+	Mm
		1298169 NFIP1_MOUSE (1-221): 1.55e-136: 383: 97.29		ITCH_MOUSE (1-757): 0: 718: 32.34
+	Hs
		1394599 NFIP1_HUMAN (1-221): 1.91e-136: 383: 100.00		ITCH_HUMAN (1-757): 0: 712: 30.88
+	Hs
		132272 NFIP1_HUMAN (1-221): 1.91e-136: 383: 100.00		WWP2_HUMAN (97-757): 0: 694: 36.69
+	Mm
		97748 NFIP1_MOUSE (1-221): 1.55e-136: 383: 97.29		E9PXB7_MOUSE (153-755): 0: 620: 40.59
+	Hs
		1394624 NFIP2_HUMAN (12-220): 5.74e-98: 290: 55.46		ITCH_HUMAN (1-757): 0: 712: 30.88
+	Hs
		132332 NFIP2_HUMAN (12-220): 5.74e-98: 290: 55.46		WWP2_HUMAN (97-757): 0: 694: 36.69
+	Hs
		1400001 NFIP1_HUMAN (1-221): 1.91e-136: 383: 100.00		NED4L_HUMAN (6-376): 3.89e-35: 145: 14.25
+	Rn
		1216890 NFIP1_RAT (1-221): 2.45e-135: 380: 97.74		NEDD4_RAT (5-380): 8.22e-34: 141: 15.45
+	Mm
		861891 NFIP1_MOUSE (1-221): 1.55e-136: 383: 97.29		NEDD4_MOUSE (8-380): 2.69e-32: 136: 15.57
+	Hs
		1413155 NFIP1_HUMAN (1-221): 1.91e-136: 383: 100.00		WWP1_HUMAN (2-395): 9.03e-25: 112: 15.53
+	Hs
		861752 NFIP1_HUMAN (1-221): 1.91e-136: 383: 100.00		NEDD4_HUMAN (72-379): 4.59e-10: 65.5: 9.39
+	Hs
		1400034 NFIP2_HUMAN (12-220): 5.74e-98: 290: 55.46		NED4L_HUMAN (6-376): 3.89e-35: 145: 14.25
+	Hs
		1430213 NFIP2_HUMAN (12-220): 5.74e-98: 290: 55.46		WWP1_HUMAN (2-395): 9.03e-25: 112: 15.53
+	Hs
		861803 NFIP2_HUMAN (12-220): 5.74e-98: 290: 55.46		NEDD4_HUMAN (72-379): 4.59e-10: 65.5: 9.39
+	Dm
		1487321 Q9VVJ5_DROME (100-221): 4.92e-53: 173: 40.98		NEDD4_DROME (2-323): 2.98e-35: 146: 16.46
+	Dm
		1466464 Q9VVJ5_DROME (100-221): 4.92e-53: 173: 40.98		SMUF1_DROME (5-373): 3.45e-29: 126: 29.65
+	Dm
		1487334 Q9VVJ5_DROME (100-221): 4.92e-53: 173: 40.98		SUDX_DROME (14-434): 1.03e-24: 112: 15.85