HitPredict

Interactor 1: AMRA1 (Q9C0C7)
Activating molecule in BECN1-regulated autophagy protein 1 (DDB1- and CUL4-associated factor 3)
Gene: AMBRA1

Interactor 2: WSB2 (Q9NYS7)
WD repeat and SOCS box-containing protein 2 (WSB-2) (CS box-containing WD protein)
Gene: WSB2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.73	1.00	0.855

Property	Details
Experiments	28514442, 33961781, unassigned3799
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	WD40~WD40
Common GO terms	GO:0000209 - protein polyubiquitination GO:0005829 - cytosol
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 1298 Hs			1 404
+	Hs
		965276 WDR5_HUMAN (3-297): 1.09e-86: 287: 18.39		NLE1_HUMAN (2-224): 2.71e-61: 207: 16.85
+	Hs
		921858 WDR5_HUMAN (3-297): 1.09e-86: 287: 18.39		COPA_HUMAN (32-334): 2.29e-46: 172: 16.57
+	Hs
		965141 WDR5_HUMAN (3-297): 1.09e-86: 287: 18.39		FBXW7_HUMAN (1-177): 1.54e-35: 140: 12.43
+	Hs
		964797 WDR5_HUMAN (3-297): 1.09e-86: 287: 18.39		WDR5_HUMAN (281-403): 5.8e-33: 128: 14.06
+	Hs
		965071 WDR5_HUMAN (3-297): 1.09e-86: 287: 18.39		WDR5B_HUMAN (269-403): 6.98e-30: 119: 14.29
+	Hs
		965151 WDR5_HUMAN (3-297): 1.09e-86: 287: 18.39		SNR40_HUMAN (278-402): 7.01e-25: 106: 13.64
+	Hs
		845264 WDR5_HUMAN (3-297): 1.09e-86: 287: 18.39		LIS1_HUMAN (327-404): 5.33e-15: 78.1: 13.25
+	At
		1247477 TAF5_ARATH (52-252): 1.74e-38: 156: 13.97		TAF5_ARATH (178-389): 1.31e-34: 137: 19.75
+	Hs
		845346 LIS1_HUMAN (123-363): 2.02e-35: 142: 12.30		KTNB1_HUMAN (8-251): 5.25e-39: 149: 16.26
+	Hs
		1334151 POC1A_HUMAN (83-434): 1.48e-41: 160: 12.30		POC1B_HUMAN (278-401): 7.12e-28: 116: 20.93
+	Hs
		1149764 TAF5_HUMAN (57-314): 6.3e-40: 162: 14.14		TAF5_HUMAN (29-192): 1.91e-24: 107: 24.41
+	Sc
		793963 TAF5_YEAST (9-127): 1.1e-32: 139: 22.22		COPA_YEAST (229-401): 2.84e-25: 110: 13.48
+	Ca
		515422 TUP1_CANAL (6-168): 1.57e-35: 144: 16.85		TUP1_CANAL (292-403): 4.17e-23: 102: 16.79
+	Sp
		207135 SWD3_SCHPO (45-208): 7.04e-46: 172: 21.69		SWD3_SCHPO (176-360): 9.28e-09: 58.9: 23.53
+	Sc
		793908 TAF5_YEAST (9-127): 1.1e-32: 139: 22.22		TAF5_YEAST (123-360): 7.34e-18: 87.8: 25.77
+	Hs
		845250 LIS1_HUMAN (123-363): 2.02e-35: 142: 12.30		LIS1_HUMAN (327-404): 5.33e-15: 78.1: 13.25
+	Mm
		988931 LIS1_MOUSE (123-363): 1.82e-35: 142: 12.30		LIS1_MOUSE (327-404): 4.86e-15: 78.1: 13.25