HitPredict

Interactor 1: THIO2 (Q9V429)
Thioredoxin-2 (DmTrx-2)
Gene: Trx2

Interactor 2: PDIA6 (Q9V438)
Protein disulfide-isomerase A6 homolog (EC 5.3.4.1) (Calcium-binding protein 1) (DmCaBP1)
Gene: CaBP1

Species: Drosophila melanogaster

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	38944040
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	Thioredoxin~Thioredoxin
Common GO terms	GO:0015035 - protein-disulfide reductase activity
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 106 Dm			1 433
+	Hs
		566679 PDIA4_HUMAN (3-105): 4.83e-26: 102: 22.02		PDIA6_HUMAN (1-433): 2.04e-117: 351: 57.21
+	Hs
		717481 PDIA3_HUMAN (3-104): 3.22e-26: 102: 24.30		PDIA6_HUMAN (1-433): 2.04e-117: 351: 57.21
+	Hs
		566671 PDIA4_HUMAN (3-105): 4.83e-26: 102: 22.02		PDIA5_HUMAN (2-399): 5.52e-67: 224: 22.30
+	Mm
		1021743 THIOM_MOUSE (5-106): 1.29e-33: 115: 38.84		ERP44_MOUSE (11-433): 1.63e-61: 206: 17.16
+	Hs
		566819 PDIA4_HUMAN (3-105): 4.83e-26: 102: 22.02		ERP44_HUMAN (11-433): 3.53e-63: 210: 17.39
+	Mm
		1362256 TXND5_MOUSE (24-106): 1.13e-27: 105: 26.14		ERP44_MOUSE (11-433): 1.63e-61: 206: 17.16
+	At
		1318507 TRXY2_ARATH (6-106): 2.94e-35: 119: 35.29		PDI11_ARATH (60-265): 2.23e-19: 92.3: 26.07
+	Dm
		929527 THIO2_DROME (1-106): 1.89e-38: 126: 100.00		PDI_DROME (62-383): 9.65e-13: 71.9: 11.47
+	Hs
		1312014 TXND5_HUMAN (24-106): 9.62e-27: 103: 25.00		DJC10_HUMAN (25-377): 8.9e-20: 94.2: 18.61
+	Hs
		566747 PDIA4_HUMAN (3-105): 4.83e-26: 102: 22.02		DJC10_HUMAN (25-377): 8.9e-20: 94.2: 18.61
+	Hs
		717533 PDIA3_HUMAN (3-104): 3.22e-26: 102: 24.30		DJC10_HUMAN (25-377): 8.9e-20: 94.2: 18.61
+	Hs
		717371 PDIA3_HUMAN (3-104): 3.22e-26: 102: 24.30		PDIA3_HUMAN (106-286): 9.99e-18: 87.3: 27.87
+	Hs
		452382 THIOM_HUMAN (5-106): 3.58e-34: 117: 37.86		PDIA1_HUMAN (62-383): 5.82e-11: 66.1: 11.44
+	Zm
		1204262 Q5EUD7_MAIZE (3-103): 1.69e-31: 115: 21.91		Q5EUD7_MAIZE (273-433): 1.42e-11: 67.6: 14.29
+	Dm
		929528 PDIA6_DROME (3-94): 5.93e-27: 104: 18.09		PDI_DROME (62-383): 9.65e-13: 71.9: 11.47
+	Hs
		452145 PDIA4_HUMAN (3-105): 4.83e-26: 102: 22.02		PDIA1_HUMAN (62-383): 5.82e-11: 66.1: 11.44
+	Hs
		566761 TXND5_HUMAN (24-106): 9.62e-27: 103: 25.00		PDIA4_HUMAN (179-384): 7.27e-09: 59.9: 9.96
+	Hs
		566571 PDIA3_HUMAN (3-104): 3.22e-26: 102: 24.30		PDIA4_HUMAN (179-384): 7.27e-09: 59.9: 9.96