HitPredict

Interactor 1: PDI (P54399)
Protein disulfide-isomerase (PDI) (dPDI) (EC 5.3.4.1)
Gene: PDI

Interactor 2: THIO2 (Q9V429)
Thioredoxin-2 (DmTrx-2)
Gene: Trx2

Species: Drosophila melanogaster

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.80	0.659

Property	Details
Experiments	22036573, 38944040
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Thioredoxin~Thioredoxin, Thioredoxin~Thioredoxin_6
Common GO terms	-
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 496 Dm			1 106
+	Hs
		452382 PDIA1_HUMAN (23-471): 2.1e-140: 415: 56.07		THIOM_HUMAN (5-106): 3.58e-34: 117: 37.86
+	Dm
		929528 PDI_DROME (1-496): 4.34e-144: 424: 100.00		PDIA6_DROME (3-94): 5.93e-27: 104: 18.09
+	Hs
		452145 PDIA1_HUMAN (23-471): 2.1e-140: 415: 56.07		PDIA4_HUMAN (3-105): 4.83e-26: 102: 22.02
+	Dm
		1191678 Q3YMU0_DROME (3-490): 4.36e-107: 329: 32.13		THIO2_DROME (1-106): 1.89e-38: 126: 100.00
+	Ce
		1165053 PDI1_CAEEL (7-489): 4.43e-117: 354: 40.66		PDI2_CAEEL (3-103): 3.39e-25: 99.4: 23.81
+	At
		1318507 PDI11_ARATH (1-475): 2.25e-104: 322: 34.69		TRXY2_ARATH (6-106): 2.94e-35: 119: 35.29
+	Dm
		1191679 Q3YMU0_DROME (3-490): 4.36e-107: 329: 32.13		PDIA6_DROME (3-94): 5.93e-27: 104: 18.09
+	At
		1192558 PDI11_ARATH (1-475): 2.25e-104: 322: 34.69		TRXH3_ARATH (19-93): 5.03e-17: 72: 48.00
+	Hs
		566671 PDIA5_HUMAN (3-496): 3.25e-73: 242: 16.94		PDIA4_HUMAN (3-105): 4.83e-26: 102: 22.02
+	Hs
		1312014 DJC10_HUMAN (77-475): 3.75e-54: 196: 15.63		TXND5_HUMAN (24-106): 9.62e-27: 103: 25.00
+	Hs
		566747 DJC10_HUMAN (77-475): 3.75e-54: 196: 15.63		PDIA4_HUMAN (3-105): 4.83e-26: 102: 22.02
+	Hs
		717533 DJC10_HUMAN (77-475): 3.75e-54: 196: 15.63		PDIA3_HUMAN (3-104): 3.22e-26: 102: 24.30
+	Hs
		566761 PDIA4_HUMAN (237-496): 2.28e-38: 150: 21.21		TXND5_HUMAN (24-106): 9.62e-27: 103: 25.00
+	Hs
		566571 PDIA4_HUMAN (237-496): 2.28e-38: 150: 21.21		PDIA3_HUMAN (3-104): 3.22e-26: 102: 24.30
+	Mm
		1021743 ERP44_MOUSE (369-493): 1.05e-26: 113: 21.37		THIOM_MOUSE (5-106): 1.29e-33: 115: 38.84
+	Hs
		717371 PDIA3_HUMAN (367-494): 2.85e-30: 125: 32.31		PDIA3_HUMAN (3-104): 3.22e-26: 102: 24.30
+	Mm
		1362256 ERP44_MOUSE (369-493): 1.05e-26: 113: 21.37		TXND5_MOUSE (24-106): 1.13e-27: 105: 26.14
+	Mm
		697731 ERP44_MOUSE (369-493): 1.05e-26: 113: 21.37		PDIA3_MOUSE (3-104): 1.92e-25: 100: 23.36