HitPredict

Interactor 1: THIO2 (Q9V429)
Thioredoxin-2 (DmTrx-2)
Gene: Trx2

Interactor 2: Q9W022 (Q9W022)
GEO01508p1 (RE49388p)
Gene: DmelCG8993

Species: Drosophila melanogaster

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	1.00	0.737

Property	Details
Experiments	22036573, 38944040
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Thioredoxin~Thioredoxin
Common GO terms	GO:0015035 - protein-disulfide reductase activity GO:0045454 - cell redox homeostasis
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 106 Dm			1 142
+	Ss
		910344 THIO_SYNY3 (6-106): 1.64e-36: 121: 33.33		THIO_SYNY3 (33-138): 3.79e-38: 126: 27.36
+	Mm
		1021679 THIOM_MOUSE (5-106): 1.29e-33: 115: 38.84		THIOM_MOUSE (37-139): 5.09e-36: 123: 46.60
+	Sc
		673323 TRX3_YEAST (2-103): 7.37e-35: 117: 39.22		TRX3_YEAST (34-126): 1.11e-35: 121: 27.96
+	Dm
		1465013 THIO2_DROME (1-106): 1.89e-38: 126: 100.00		PDIA6_DROME (9-126): 4.88e-29: 111: 21.01
+	Sc
		646584 TRX1_YEAST (1-105): 4.52e-37: 122: 42.86		TRX2_YEAST (34-138): 7.77e-34: 115: 35.24
+	Sc
		652850 TRX2_YEAST (1-106): 5.74e-37: 122: 44.34		TRX2_YEAST (34-138): 7.77e-34: 115: 35.24
+	Zm
		1204262 Q5EUD7_MAIZE (3-103): 1.69e-31: 115: 21.91		Q5EUD7_MAIZE (31-135): 1.08e-30: 114: 25.93
+	Hs
		566679 PDIA4_HUMAN (3-105): 4.83e-26: 102: 22.02		PDIA6_HUMAN (35-140): 3.11e-33: 122: 24.30
+	Hs
		717481 PDIA3_HUMAN (3-104): 3.22e-26: 102: 24.30		PDIA6_HUMAN (35-140): 3.11e-33: 122: 24.30
+	Dm
		1465312 PDIA6_DROME (3-94): 5.93e-27: 104: 18.09		Q9W022_DROME (1-142): 7.95e-35: 119: 100.00
+	Hs
		717371 PDIA3_HUMAN (3-104): 3.22e-26: 102: 24.30		PDIA3_HUMAN (1-137): 4.76e-30: 114: 19.86
+	Hs
		566761 TXND5_HUMAN (24-106): 9.62e-27: 103: 25.00		PDIA4_HUMAN (35-140): 1.07e-28: 111: 28.44
+	Hs
		566571 PDIA3_HUMAN (3-104): 3.22e-26: 102: 24.30		PDIA4_HUMAN (35-140): 1.07e-28: 111: 28.44
+	Rn
		801669 PDIA4_RAT (3-105): 5.81e-24: 96.4: 23.85		PDIA4_RAT (2-137): 1.18e-26: 105: 18.44
+	Ss
		910421 THIO1_SYNY3 (13-92): 5.13e-18: 74.3: 38.75		THIO1_SYNY3 (40-124): 1.07e-36: 123: 34.12
+	Sp
		154276 TRX1_SCHPO (1-106): 2.41e-35: 117: 48.11		TRX1_SCHPO (36-123): 2.86e-13: 63.2: 35.23