HitPredict

Interactor 1: EPHA3 (O13146)
Ephrin type-A receptor 3 (EC 2.7.10.1) (EPH-like kinase 1) (Tyrosine-protein kinase receptor ZEK1)
Gene: EPHA3

Interactor 2: EFNB2 (O73874)
Ephrin-B2a
Gene: efnb2a

Species: Danio rerio

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	26190107
Identification Methods	avexis
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ephrin~Ephrin_lbd
Common GO terms	GO:0005886 - plasma membrane GO:0048013 - ephrin receptor signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 981 Dr			1 332
+	Dr
		267297 Q5ZEW1_DANRE (2-977): 0: 1195: 61.17		EFNB2_DANRE (1-332): 2.15e-165: 465: 100.00
+	Dr
		148815 EPHA3_DANRE (1-981): 0: 1249: 100.00		Q90Z31_DANRE (12-332): 1.08e-139: 400: 48.02
+	Mm
		914521 EPHA4_MOUSE (4-981): 0: 1157: 62.68		EFNB2_MOUSE (3-332): 1.42e-165: 466: 65.56
+	Hs
		914389 EPHA4_HUMAN (2-981): 0: 1157: 61.95		EFNB2_HUMAN (3-332): 8.55e-165: 464: 65.56
+	Rn
		486647 EPHB1_RAT (22-981): 0: 1157: 54.71		Q6P7B6_RAT (6-332): 1.17e-163: 461: 50.87
+	Mm
		914177 EPHB1_MOUSE (22-981): 0: 1158: 54.82		EFNB1_MOUSE (6-332): 5.45e-162: 457: 51.45
+	Dr
		1221071 Q5ZEW1_DANRE (2-977): 0: 1195: 61.17		Q90Z31_DANRE (12-332): 1.08e-139: 400: 48.02
+	Hs
		932078 EPHA4_HUMAN (2-981): 0: 1157: 61.95		EFNB3_HUMAN (28-332): 1.04e-104: 312: 41.40
+	Dr
		148814 EPHA3_DANRE (1-981): 0: 1249: 100.00		Q90YC5_DANRE (27-208): 1.98e-64: 204: 26.20
+	Dr
		148813 EPHA3_DANRE (1-981): 0: 1249: 100.00		EFNA5_DANRE (11-192): 1.42e-63: 203: 25.76
+	Dr
		148812 EPHA3_DANRE (1-981): 0: 1249: 100.00		EFNA2_DANRE (26-179): 1.54e-55: 181: 27.85
+	Dr
		47642 Q5ZEW1_DANRE (2-977): 0: 1195: 61.17		A0A8M1Q1X6_DANRE (9-209): 8.43e-65: 205: 23.45
+	Dr
		1221070 Q5ZEW1_DANRE (2-977): 0: 1195: 61.17		Q90YC5_DANRE (27-208): 1.98e-64: 204: 26.20
+	Dr
		1009395 Q5ZEW1_DANRE (2-977): 0: 1195: 61.17		EFNA5_DANRE (11-192): 1.42e-63: 203: 25.76
+	Dr
		1009394 Q5ZEW1_DANRE (2-977): 0: 1195: 61.17		EFNA2_DANRE (26-179): 1.54e-55: 181: 27.85
+	Hs
		635249 EPHA4_HUMAN (2-981): 0: 1157: 61.95		EFNA1_HUMAN (7-173): 2.19e-66: 209: 26.74
+	Hs
		914527 EPHA4_HUMAN (2-981): 0: 1157: 61.95		EFNA5_HUMAN (12-196): 3.8e-65: 206: 23.76
+	Hs
		914227 EPHA4_HUMAN (2-981): 0: 1157: 61.95		EFNA4_HUMAN (9-193): 9.56e-53: 174: 24.06
+	Hs
		231304 EPHA4_HUMAN (2-981): 0: 1157: 61.95		EFNA2_HUMAN (26-157): 3.9e-48: 162: 29.58
+	Hs
		231310 EPHA7_HUMAN (9-981): 0: 1153: 58.38		EFNA2_HUMAN (26-157): 3.9e-48: 162: 29.58