Protein: EFNA1
Ephrin-A1 (EPH-related receptor tyrosine kinase ligand 1) (LERK-1) (Immediate early response protein B61) (Tumor necrosis factor alpha-induced protein 4) (TNF alpha-induced protein 4) [Cleaved into: Ephrin-A1, secreted form]

Gene: EFNA1
Organism: Homo sapiens
Interactions: 96
UniProt ID: P20827

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0001525 - angiogenesis
GO:0003180 - aortic valve morphogenesis
GO:0003183 - mitral valve morphogenesis
GO:0003199 - endocardial cushion to mesenchymal transition involved in heart valve formation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

635236

EPHA2
Ephrin type-A receptor 2

7

20

Small-scale

0.961

High

635249

EPHA4
Ephrin type-A receptor 4

2

20

Small-scale

0.768

High

635237

EPHA3
Ephrin type-A receptor 3

1

20

Small-scale

0.647

High

635230

EFNA1
Ephrin-A1

1

5

High-throughput

0.618

High

635238

EPHB2
Ephrin type-B receptor 2

1

20

High-throughput

0.618

High

635247

EFNA3
Ephrin-A3

1

5

High-throughput

0.618

High

635248

EPHB4
Ephrin type-B receptor 4

1

20

High-throughput

0.618

High

390318

CXCL7
Platelet basic protein

2

0

High-throughput

0.594

High

635278

KAT5
Histone acetyltransferase KAT5

1

0

High-throughput

0.518

High

635250

HUNK
Hormonally up-regulated neu tumor-associated kinase

1

1

High-throughput

0.494

High

635285

GARE1
GRB2-associated and regulator of MAPK protein 1

1

0

High-throughput

0.493

High

557854

XRCC6
X-ray repair cross-complementing protein 6

1

0

High-throughput

0.486

High

362757

EGFR
Epidermal growth factor receptor

1

20

High-throughput

0.479

High

389959

ALBU
Albumin

1

2

High-throughput

0.479

High

407390

K2C1
Keratin, type II cytoskeletal 1

1

19

High-throughput

0.479

High

420356

AT1A1
Sodium/potassium-transporting ATPase subunit alpha-1

1

2

High-throughput

0.479

High

438926

CD5
T-cell surface glycoprotein CD5

1

5

High-throughput

0.479

High

456190

CATD
Cathepsin D

1

1

High-throughput

0.479

High

457228

TBB5
Tubulin beta chain

1

15

High-throughput

0.479

High

474475

VIME
Vimentin

1

20

High-throughput

0.479

High

534624

BIP
Endoplasmic reticulum chaperone BiP

1

4

High-throughput

0.479

High

536484

HSP7C
Heat shock cognate 71 kDa protein

1

1

High-throughput

0.479

High

572986

KPYM
Pyruvate kinase PKM

1

1

High-throughput

0.479

High

573324

ENPL
Endoplasmin

1

2

High-throughput

0.479

High

584951

GNS
N-acetylglucosamine-6-sulfatase

1

2

High-throughput

0.479

High

587556

DESP
Desmoplakin

1

5

High-throughput

0.479

High

635231

RS3
Small ribosomal subunit protein uS3

1

2

High-throughput

0.479

High

635232

ITA3
Integrin alpha-3

1

3

High-throughput

0.479

High

635235

LYOX
Protein-lysine 6-oxidase

1

4

High-throughput

0.479

High

635241

BASI
Basigin

1

3

High-throughput

0.479

High

635243

BMR1A
Bone morphogenetic protein receptor type-1A

1

1

High-throughput

0.479

High

635246

TMEDA
Transmembrane emp24 domain-containing protein 10

1

1

High-throughput

0.479

High

635251

ACTB
Actin, cytoplasmic 1

1

4

High-throughput

0.479

High

635257

RL23
Large ribosomal subunit protein uL14

1

2

High-throughput

0.479

High

635259

RL11
Large ribosomal subunit protein uL5

1

2

High-throughput

0.479

High

635260

EF1A1
Elongation factor 1-alpha 1

1

2

High-throughput

0.479

High

635261

EWS
RNA-binding protein EWS

1

2

High-throughput

0.479

High

635265

LG3BP
Galectin-3-binding protein

1

4

High-throughput

0.479

High

635269

TBA1A
Tubulin alpha-1A chain

1

12

High-throughput

0.479

High

635270

CCD25
Coiled-coil domain-containing protein 25

1

1

High-throughput

0.479

High

635271

HORN
Hornerin

1

2

High-throughput

0.479

High

635287

FLRT3
Leucine-rich repeat transmembrane protein FLRT3

1

1

High-throughput

0.479

High

635289

LOXL2
Lysyl oxidase homolog 2

1

8

High-throughput

0.479

High

635290

HYOU1
Hypoxia up-regulated protein 1

1

3

High-throughput

0.479

High

141320

DDX3X
ATP-dependent RNA helicase DDX3X

1

0

High-throughput

0.458

High

445732

ENOA
Alpha-enolase

1

0

High-throughput

0.458

High

467369

4F2
Amino acid transporter heavy chain SLC3A2

1

0

High-throughput

0.458

High

635244

OST48
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit

1

0

High-throughput

0.458

High

635275

OR6T1
Olfactory receptor 6T1

1

0

High-throughput

0.458

High

635277

ESR2
Estrogen receptor beta

1

0

High-throughput

0.458

High

635284

DHX33
ATP-dependent RNA helicase DHX33

1

0

High-throughput

0.458

High

137032

PLOD2
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2

1

6

High-throughput

0.437

High

385052

K1C14
Keratin, type I cytoskeletal 14

1

20

High-throughput

0.437

High

385238

K2C6A
Keratin, type II cytoskeletal 6A

1

20

High-throughput

0.437

High

407252

K2C6B
Keratin, type II cytoskeletal 6B

1

20

High-throughput

0.437

High

476267

K1C16
Keratin, type I cytoskeletal 16

1

20

High-throughput

0.437

High

535923

MYH3
Myosin-3

1

2

High-throughput

0.437

High

556839

MYH1
Myosin-1

1

2

High-throughput

0.437

High

556896

MYH7
Myosin-7

1

2

High-throughput

0.437

High

566098

K1C10
Keratin, type I cytoskeletal 10

1

20

High-throughput

0.437

High

566332

K2C5
Keratin, type II cytoskeletal 5

1

20

High-throughput

0.437

High

570355

GFAP
Glial fibrillary acidic protein

1

20

High-throughput

0.437

High

635234

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

2

High-throughput

0.437

High

635239

RL12
Large ribosomal subunit protein uL11

1

2

High-throughput

0.437

High

635240

K1C9
Keratin, type I cytoskeletal 9

1

20

High-throughput

0.437

High

635242

K22E
Keratin, type II cytoskeletal 2 epidermal

1

20

High-throughput

0.437

High

635245

K2C6C
Keratin, type II cytoskeletal 6C

1

19

High-throughput

0.437

High

635254

RS4X
Small ribosomal subunit protein eS4, X isoform

1

1

High-throughput

0.437

High

635255

ACTA
Actin, aortic smooth muscle

1

3

High-throughput

0.437

High

635258

RL30
Large ribosomal subunit protein eL30

1

2

High-throughput

0.437

High

635262

PLOD1
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1

1

6

High-throughput

0.437

High

635264

K1C17
Keratin, type I cytoskeletal 17

1

20

High-throughput

0.437

High

635266

K1H1
Keratin, type I cuticular Ha1

1

20

High-throughput

0.437

High

635273

GT251
Procollagen galactosyltransferase 1

1

6

High-throughput

0.437

High

635280

ARHGH
Rho guanine nucleotide exchange factor 17

1

2

High-throughput

0.437

High

635281

PLCA
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha

1

2

High-throughput

0.437

High

635282

TBB6
Tubulin beta-6 chain

1

15

High-throughput

0.437

High

635286

KCTD5
BTB/POZ domain-containing protein KCTD5

1

2

High-throughput

0.437

High

635288

TGRM1
TOG array regulator of axonemal microtubules protein 1

1

1

High-throughput

0.437

High

635291

SNX13
Sorting nexin-13

1

3

High-throughput

0.437

High

635233

EF1G
Elongation factor 1-gamma

1

0

High-throughput

0.282

High

635279

CLP1L
Lipid scramblase CLPTM1L

1

0

High-throughput

0.269

Low

187286

SHIP2
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2

1

0

Small-scale

0.261

Low

191291

P4HA2
Prolyl 4-hydroxylase subunit alpha-2

1

0

High-throughput

0.249

Low

445644

KCRM
Creatine kinase M-type

1

0

High-throughput

0.249

Low

635252

RL15
Large ribosomal subunit protein eL15

1

0

High-throughput

0.249

Low

635256

VISL1
Visinin-like protein 1

1

0

High-throughput

0.249

Low

635263

RL6
Large ribosomal subunit protein eL6

1

0

High-throughput

0.249

Low

635267

EXOS6
Exosome complex component MTR3

1

0

High-throughput

0.249

Low

635268

KAZRN
Kazrin

1

0

High-throughput

0.249

Low

635274

SMG8
Nonsense-mediated mRNA decay factor SMG8

1

0

High-throughput

0.249

Low

635276

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.249

Low

635283

TM109
Voltage-gated monoatomic cation channel TMEM109

1

0

High-throughput

0.249

Low

635253

SUMO2
Small ubiquitin-related modifier 2

1

0

High-throughput

0.238

Low

635272

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

Small-scale

0.238

Low


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Last updated: 11Aug2025